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Ginkgo flavone liposome oral emulsion formula and preparation method thereof

A technology of ginkgo flavonoids and ginkgo flavonoids, which is applied in the field of natural product extract preparations, can solve the problems of unauthorized access, and achieve good taste, broad-spectrum pH stability, and mature and stable effects

Inactive Publication Date: 2013-07-03
孟泉科 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In 2006, Beijing Qiyuan Yide Pharmaceutical Research Institute submitted a series of technical patents on "Chinese medicine preparations for the treatment of cardiovascular and cerebrovascular diseases and their preparation methods", but none of them were authorized

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment one: preparation of ginkgo flavone liposome oral milk by injection method

[0043] 1) The raw and auxiliary materials used in the production of ginkgo flavonoid liposome oral milk are inspected according to the corresponding quality standards, and all of them should meet the quality standards.

[0044] 2) Prepare ethanol solution of ginkgo flavonoids.

[0045] 2.1. Weigh 45 grams of ginkgo flavonoids, 10 grams of vitamin E, 5 grams of cholesterol, and 75 grams of phospholipids in the same container.

[0046] 2.2. Measure 250ml of 95% ethanol or absolute ethanol in the formula, and pour it into the container in 2.1.

[0047]2.3. Under the condition of 20-80°C water bath, stir in the container of 2.1 with a stirring paddle, and the stirring speed is controlled at 5-100rpm, so that it can be dissolved into a transparent and uniform solution.

[0048] 2.4. Filter the solution in 2.3 with a 0.22 micron sterilizing filter membrane (filter), and carry out bacteria...

Embodiment 2

[0059] Embodiment two film method prepares ginkgo flavone liposome oral milk

[0060] 1) All raw and auxiliary materials used for the production of ginkgo flavonoid liposome oral milk are inspected according to the corresponding quality standards, and all should meet the quality standards.

[0061] 2) Prepare ethanol solution of ginkgo flavonoids.

[0062] 2.1. Weigh 45 grams of ginkgo flavonoids, 10 grams of vitamin E, 5 grams of cholesterol, and 75 grams of phospholipids in the same container.

[0063] 2.2. Measure 250ml of 95% ethanol or absolute ethanol in the formula, and pour it into the container in 2.1.

[0064] 2.3. Under the condition of 20-80°C water bath, stir in the container of 2.1 with a stirring paddle, and the stirring speed is controlled at 5-100rpm, so that it can be dissolved into a transparent and uniform solution.

[0065] 2.4. Filter the solution in 2.3 with a 0.22 micron sterilizing filter membrane (filter), and carry out bacterial counting culture on...

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PUM

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Abstract

The invention relates to a ginkgo flavone liposome oral emulsion formula and a preparation method thereof. In the prepared oral emulsion, a ratio of ginkgo flavone to phospholipid is 0.5-1:5:1. The oral emulsion also comprises vitamin E, cholesterol, sorbitol, beta-cyclodextrin, polyethylene glycol (PEG), and lactose. The ginkgo flavone liposome oral emulsion provided by the invention can endure 30min of heat sterilization treatment under a temperature of 121 DEG C, and has high tolerance against low-pH environments. Therefore, a preparation requirement for large change in stomach and intestinal pH values after oral administration is satisfied. The liposome can be digested and absorbed by human body, such that ginkgo flavone pharmacological effect can be improved.

Description

technical field [0001] The present invention relates to the field of natural product extract formulations. Provided is a formula of ginkgo flavonoid liposome oral milk conforming to the current "Good Manufacturing Practice for Drugs" and a preparation method thereof. Background technique [0002] In the early 1980s, researchers from Zhejiang Kangenbei Pharmaceutical Co., Ltd. and the Shanghai Institute of Materia Medica, Chinese Academy of Sciences made every effort to extract medicinal ingredients from Ginkgo biloba leaves for the first time, and developed the first domestic drug developed by using modern natural medicinal technology. The listed Ginkgo biloba preparation "Tianbaoning". So far, my country has approved 116 ginkgo biloba preparations, including tablets, capsules, soft capsules, injections, granules, dispersible tablets, dripping pills, oral liquids and other dosage forms. "Ginador" of the French factory and "Danacon" of the French Bofu-Ipsen Pharmaceutical Co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K9/127A61K47/40A61P9/10A61P25/28A61P9/12A61P7/02A61P39/06A61P37/04A61P35/00
Inventor 孟泉科马凤仙吉仙枝曹江华石正国
Owner 孟泉科
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