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Preparation of natural polymer base hemostasis dressing

A natural polymer, hemostatic dressing technology, applied in the fields of medical science, absorbent pads, bandages, etc., can solve the problems such as the effect to be improved, and achieve the effect of good air permeability, good hemostatic effect, and good wound protection.

Active Publication Date: 2013-06-05
ROOSIN MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to literature reports, Kim et al. (Kim HJ.Polyelectroylte complex composed of chitosan and sodium alginate for wound dressing application.J Biomater Sci Polym Ed.1999;10(5):543-56.) used chitosan and sodium alginate A high molecular weight polymer with a two-layer structure was prepared for wound healing, and the results showed that it could significantly promote the formation of granulation tissue, but its effect on rapid hemostasis needs to be improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1) Dissolve chitosan (Mw=50000g / mol) directly in a mixed solution of deionized water and formic acid (FA), prepare a solution with a concentration of 5wt%, and stir at room temperature until completely dissolved;

[0022] 2) Dissolve hyaluronic acid (Mw=500000g / mol) directly in deionized water to prepare a solution with a concentration of 0.05wt%, and stir at room temperature until completely dissolved;

[0023] 3) Transfer the chitosan solution prepared in step 1) to a liquid nitrogen freezing device, turn on the freezing device, freeze the prepared chitosan solution in a liquid nitrogen environment, and then transfer the frozen chitosan solution to In the freeze dryer, under the conditions of temperature ~-80°C and vacuum degree ~1Pa, carry out freeze-drying treatment for more than 48 hours to obtain a "honeycomb" chitosan fiber membrane; (see figure 1 )

[0024] 4) Pour the hyaluronic acid solution prepared in step 2) on the chitosan fiber membrane, and add a small ...

Embodiment 2

[0027] 1) Dissolve chitosan (Mw=100000g / mol) directly in a mixed solution of deionized water and formic acid (FA), prepare a solution with a concentration of 3wt%, and stir at room temperature until completely dissolved;

[0028] 2) Dissolve hyaluronic acid (Mw=1000000g / mol) directly in deionized water to prepare a solution with a concentration of 0.03wt%, and stir at room temperature until completely dissolved;

[0029] 3) Transfer the chitosan solution prepared in step 1) to a liquid nitrogen freezing device, turn on the freezing device, freeze the prepared chitosan solution in a liquid nitrogen environment, and then transfer the frozen chitosan solution to In the freeze dryer, under the condition of temperature ~-80℃ and vacuum degree ~1Pa, carry out freeze-drying treatment for more than 48 hours to obtain a "honeycomb" chitosan fiber membrane;

[0030] 4) Pour the hyaluronic acid solution prepared in step 2) on the chitosan fiber membrane, and add a small amount of thrombi...

Embodiment 3

[0033] 1) Dissolve chitosan (Mw=200000g / mol) directly in a mixed solution of deionized water and formic acid (FA), prepare a solution with a concentration of 1wt%, and stir at room temperature until completely dissolved;

[0034] 2) Dissolve hyaluronic acid (Mw=2000000g / mol) directly in deionized water to prepare a solution with a concentration of 0.01wt%, and stir at room temperature until completely dissolved;

[0035] 3) Transfer the chitosan solution prepared in step 1) to a liquid nitrogen freezing device, turn on the freezing device, freeze the prepared chitosan solution in a liquid nitrogen environment, and then transfer the frozen chitosan solution to In the freeze dryer, under the condition of temperature ~-80℃ and vacuum degree ~1Pa, carry out freeze-drying treatment for more than 48 hours to obtain a "honeycomb" chitosan fiber membrane;

[0036] 4) Pour the hyaluronic acid solution prepared in step 2) on the chitosan fiber membrane, and add a small amount of thrombi...

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Abstract

The invention provides a method of preparing a natural polymer base composite polyelectrolyte hemostasis dressing. A natural polymer base composite polyelectrolyte solution with traces of thrombin is prepared by preparing polyanion and polycation solutions with different concentrations. The composite polyelectrolyte solution with the traces of thrombin is transferred to a liquid nitrogen refrigeration device and is enabled to be frozen in a liquid nitrogen environment. Under the conditions that the temperature is -80 DEG C and the vacuum degree is -1 pascal, freeze-drying treatment is conducted for more than 48 hours by a freezer dryer, and a high porosity composite polyelectrolyte fiber dressing with the traces of thrombin is obtained. The high porosity natural composite polyelectrolyte fiber dressing with the traces of thrombin has wide application values in aspects such as hemostasis, bacteriostat and wound healing promotion.

Description

technical field [0001] The invention relates to a preparation method of a natural polymer composite polyelectrolyte hemostatic dressing, belonging to the field of biomedical materials. Background technique [0002] Traditional hemostatic dressings are mostly gauze and cotton balls made of cotton fibers. Although they have certain moisture absorption and protection effects, they tend to stick to the wound during the healing process, causing secondary damage. With the improvement of the hemostatic performance requirements of the medical circles in various countries, it is imperative to develop hemostatic dressings with excellent performance. Due to the characteristics of non-toxic, good biocompatibility and degradability, natural polymers have attracted great attention in the research of hemostatic dressings. According to literature reports, Kim et al. (Kim HJ.Polyelectroylte complex composed of chitosan and sodium alginate for wound dressing application.J Biomater Sci Polym ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28A61L15/28A61L15/42A61L15/44C08L5/08C08L5/04
Inventor 马贵平陈洁聂俊方大为包容
Owner ROOSIN MEDICAL CO LTD
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