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Gel used for skin diseases and preparation method thereof

A technology of gel and disease, applied in the field of medical dressings, to achieve the effect of inhibiting allergies, antipyretic allergies, and easy to use

Active Publication Date: 2014-08-13
GUIZHOU YANGSHENG MEDICAL INSTR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no gel application for skin diseases with carboxymethyl chitosan as the main active ingredient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment l

[0025] Example 1 Weigh batching according to following raw material quality: carboxymethyl chitosan 1.5g, stearic acid 1.8g, glycerol monostearate 0.4g, potassium carbonate 0.15g, triethanolamine 0.05g, glycerol 1.7g, Paeonol 3g, purified water 91.4g. The preparation method is: take the matrix made of stearic acid, potassium carbonate, glycerol monostearate, triethanolamine, glycerol, and partly purified water, and heat it; then add paeonol and stir evenly to obtain ointment ; Add carboxymethyl chitosan to the remaining purified water, stir to dissolve it, and then add it to the ointment; finally, stir slowly to form a gel to obtain the finished product.

Embodiment 2

[0026] Example 2 Weigh batching according to following raw material quality: carboxymethyl chitosan 3.5g, stearic acid 8g, glycerol monostearate 3g, potassium carbonate 1.5g, triethanolamine 0.5g, glycerol 17g, paeonol 4.5g, 62g of purified water. The preparation method is the same as in Example 1 to obtain a gel product for skin disorders.

Embodiment 3

[0027] Example 3 Weigh batching according to following raw material quality: carboxymethyl chitosan 5g, stearic acid 10g, glyceryl monostearate 5g, potassium carbonate 4g, triethanolamine 1.3g, glycerol 25g, paeonol 12g, Purified water 37.7g. The preparation method is the same as in Example 1 to obtain a gel product for skin disorders.

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PUM

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Abstract

The invention discloses a gel for skin diseases. The gel is formulated with carboxymethyl chitosan as the main active ingredient, and its raw materials include: carboxymethyl chitosan, stearic acid, monostearin glycerol ester, potassium carbonate, triethanolamine, glycerin, paeonol and purified water. The preparation method includes: 1. weighing; 2. taking the matrix made of stearic acid, potassium carbonate, glycerol monostearate, triethanolamine, glycerin and purified water, and heating; 3. adding paeonol, Stir evenly to obtain an ointment; ④ add carboxymethyl chitosan to purified water, stir to dissolve it, and then add it to the ointment; ⑤ Stir slowly to form a gel to obtain the finished product. The gel of the present invention has the functions of sterilization, anti-inflammatory, antipruritic, scar reduction, moisturizing and skin care; it has the advantages of good stability, good bactericidal effect and convenient use, and is suitable for acne vulgaris, skin eczema, photosensitive dermatitis and other skin disease.

Description

technical field [0001] The present invention relates to medical dressings, in particular to dressings containing gels of chitosan derivatives, in particular to gels for skin diseases. Background technique [0002] Chitosan (chitosan) is the only positively charged branched polysaccharide in nature. It has antibacterial, antitumor, immune enhancement and other functions. It has good biocompatibility and is non-irritating and non-toxic. Due to 2- NH 2 Chitosan has a certain antibacterial function, but the antibacterial performance is limited, and is affected by conditions such as chitosan molecular weight and deacetylation degree. After grafting quaternary ammonium salt on the molecular chain of chitosan, its antibacterial performance can be significantly improved. As a natural polycation, chitosan is easy to accumulate in the cell wall, preventing nutrients from entering the cell through the cell wall, causing cell failure and death; while low molecular weight chitosan can ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/722A61P31/02A61P29/00A61P17/04A61P17/02A61P17/16A61P17/10A61P17/00A61L15/28A61L15/18A61L15/20A61L15/44A61L15/42A61L15/48A61K31/12
Inventor 聂开品黄昌平郑茂鑫
Owner GUIZHOU YANGSHENG MEDICAL INSTR
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