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External preparation for treating senile vaginitis and preparation method of external preparation

A vaginitis and senile technology, applied in the field of traditional Chinese medicine, can solve the problems of difficult placement of patients and increase the difficulty of treatment, and achieve the effects of no toxic side effects, not easy to cause complications, and easy absorption.

Inactive Publication Date: 2013-05-01
李秀娟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the treatment method of placing antibiotic powder in the vagina is difficult for patients to place by themselves, which increases the difficulty of treatment.

Method used

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  • External preparation for treating senile vaginitis and preparation method of external preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Preparation of traditional Chinese medicine composition fumigation lotion 1

[0067] Ephedra 25g, Cnidium 50g, Baibu 20g, Acanthopanax 55g, Cockscomb 25g, golden buckwheat 25g, Eclipta 75g, Cistanche 45g, mulberry octopus 25g, Coptis 35g, catechin 20g, cloves 25g, barley Winter 45g, Burdock 25g, Cimicifuga 40g, Angelica dahurica 25g, Donglingcao 20g, Shayuanzi 35g, Uncaria 40g, Chushizi 35g, Rehmannia glutinosa 25g, Miltonia 40g, mix, add 3kg of water, decoct for 5 hour, the decoction was filtered, and 1.5 kg of water was added to the filter residue again, decocted for 5 hours, the decoction was filtered, the two decoctions were combined, concentrated until the crude drug concentration was 1g / ml, and fumigation solution 1 was obtained.

Embodiment 2

[0068] The acute toxicity test of embodiment 2 smoked lotion 1

[0069] The 18 rabbits were randomly divided into 3 groups, namely the matrix group, the treatment group with intact skin and the treatment group with damaged skin. 6 rabbits in each group, half male and half female, use 10% sodium sulfide to depilate the back of the rabbits, the depilated area is about 150cm 2 . The production of damaged skin is scratched with a sterile iron file (to the extent of bleeding), and after hair removal, apply fumigation solution 1 at 6g (crude drug) / kg (equivalent to 6 times the clinical dosage) on the depilated area and use a non-irritating 24 hours after administration, from 1, 24, 48, 72 hours to the seventh day, observe and record the changes of the animals' body weight, fur, luster, diet, eyes and mucous membranes every day , respiratory center, nervous system, limb activity and death, and the rabbits were executed seven days later, and the changes in the heart, liver, spleen, ...

Embodiment 3

[0072] The skin irritation test of embodiment 3 smoked lotion 1

[0073] Take 3 New Zealand white rabbits, weighing 2.5±0.5kg. 24 hours before the administration, remove the hair on both sides of the rabbit’s back and spine, each 3×2 square centimeters, take 5ml of fumigation and lotion 1, and apply it on one side where the hair is removed, and the other Apply sesame oil on one side as a blank control, remove the residual test substance with warm boiled water 4 hours after application, observe the complete skin reaction at 4, 24, 48, and 72 hours, the test results are shown in Table 1.

[0074] Table 1 Complete skin irritation test score results

[0075]

[0076] As can be seen from the results in Table 1, the average score of the complete skin irritation response is zero, indicating that the fumigated lotion prepared by the present invention is non-irritating to the skin.

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Abstract

The invention provides a traditional Chinese medicine composition for treating senile vaginitis, which comprises the following raw materials: Chinese ephedra, fructus cnidii, radix stemonae, acanthopanax, cockscomb, fagopyrum cymosum, eclipta, desertliving cistanche, mantis egg-case, coptis root, catechu, clove, liriope spicata, burdock, cimicifugae foetidae, radix angelicae, rabdosia, flatstem milkvetch seeds, uncaria, paper mulberry fruits, prepared rehmannia root and suberect spatholobus stem. The traditional Chinese medicine composition is an external preparation, is used partially, is easy to absorb and remarkable in curative effect, has no toxic or side effects, and does not cause complications easily.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to an external preparation for treating senile vaginitis. Background technique [0002] At present, the world's population tends to be aging, so that the number and proportion of the elderly in the population are increasing rapidly, and the diseases unique to the elderly are receiving more and more attention. [0003] Senile vaginitis is a prominent manifestation of ovarian function decline and relative insufficiency of estrogen in the vagina. It is a common and frequently-occurring disease in postmenopausal women. The incidence rate is as high as 30% to 58.6%, which seriously affects the quality of life of elderly patients. . [0004] Modern medicine believes that the occurrence of this disease is due to the decline of ovarian function, the decrease of estrogen level, the atrophy of vaginal wall, the thinning of mucous membrane, the decrease of glycogen in epi...

Claims

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Application Information

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IPC IPC(8): A61K36/904A61K9/06A61K9/00A61P15/02
Inventor 李秀娟王占虹徐艳艳万淑燕郝力
Owner 李秀娟
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