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Pharmaceutical composition for increasing hypoxia tolerance

A composition, tolerance technology, applied in the direction of application, food science, food preparation, etc.

Active Publication Date: 2013-04-24
ZHEJIANG ADAMERCK BIOPHARMLABS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the short half-life of ingested arginine, which is only 1 hour, direct supplementation of arginine fails to effectively increase the concentration of arginine in the blood and cells in the body

Method used

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  • Pharmaceutical composition for increasing hypoxia tolerance
  • Pharmaceutical composition for increasing hypoxia tolerance
  • Pharmaceutical composition for increasing hypoxia tolerance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Dose: 800mg / kg / day / group.Test samples are prepared with heavy steaming water, and the stomach is used through the mouth for 7 consecutive days.

[0017] Test method: After the last time, the mice will be broken from the neck from the neck for 1 hour, and the mice will be recorded with a stopwatch and the time will be stopped.See Table 1.

[0018]

[0019] Example 2 tablets preparation

Embodiment 2

[0020] 1. Table 2 raw materials, supplements and supplementary materials over 80 measuring sieves, spare;

[0021] 2. Called raw materials according to the amount of recipes: melonin, birdine hydrochloride, safflower extract, ginkgo leaf extract, jujube extract, α-sulfenic acid, and one-half of the recipe amountCellulose is mixed for 10-15 minutes, and 80%ethanol solution is prepared for soft materials;

[0022] 3. Siege grains through 16 mesh sieve; dry at 60 ° C to 65 ° C. Add the whole grain to the flow of microfiflower silicone, magnesium magnesium and lubricant, and the remaining collapse hydroxyl cellulose., Coat.

[0023]

[0024] Example 3 Improvement of hypoxia tolerance Experimination experiments.

Embodiment 3

[0025] Experimental animals: 144 mice of healthy female ICR species are selected, and they are randomly divided into 4 groups by weight, 12 in each group.

[0026] Dose design: Set 400mg / kg / d (equivalent to 10 times the adult's daily weight recommendation of adults per kilogram of weight), 800mg / kg / d, and 1200mg / kg / d three dosage groups. There is a normal control group at the same time.The sample is prepared with double steamed water. Each group is 20ml / kgb WT daily.The normal control group daily stomach and other amounts of water.

[0027] Experimental method: Put the mice into the 250ml grinding bottle (capacity error ± 1ml) with 5G sodium lime with 5G sodium lime 1 hour.It also records the survival time of mice to resist oxygen dehydration. The original data uses SPSS statistical software to first test the variance, and the variance is available, and then uses two or two comparison statistics between multiple experimental groups and one control group.

[0028] Experimental resu...

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PUM

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Abstract

The invention provides a pharmaceutical composition for increasing hypoxia tolerance, which is composed of natural amino acids, natural extracts and alpha-lipoic acid. The natural amino acids in the composition comprise ornithine or salts thereof and citrulline or salts thereof. The natural extracts are one or more substances selected from a safflower extract, a gingko extract or a Chinese-date extract. The pharmaceutical composition disclosed by the invention is capable of obviously increasing acute cerebral ischemic hypoxia survival time and increasing the oxygen utilization rate of tissue cells and has the function of increasing hypoxia tolerance. The pharmaceutical composition disclosed by the invention is prepared into troches or granules, which are applied to being taken by students, brain workers, the old and weak and sub-healthy people caused by hypoxia.

Description

Technical field [0001] The present invention is a health food field that involves a medicinal composition that can improve hypoxia resistance. It consists of natural amino acids and natural extracts and α-sulfuric acid. Background technique [0002] Fierce competition, intense rhythm, excessive brain and imbalanced diet structure, and environmental pollution, which causes the body's ability to use oxygen use, shows a performance of one more and three declinesDecreased, adaptable ability.It is manifested as "hypoxic syndrome" phenomenon such as fatigue, fatigue, emotional instability, aging, impotence, insomnia, etc. [0003] Sinine has the effect of improving hypoxia tolerance, such as being used to treat diseases such as hypoxic pulmonary hypertension.However, because the semi -permanent semi -permanent intake is very short, only an hour, the directly supplementing the arginine concentration in the body's blood and cells in the body is not effectively supplemented.Only by taking...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/30A23L1/305
Inventor 漆又毛
Owner ZHEJIANG ADAMERCK BIOPHARMLABS
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