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Composition of oryzanol and proton pump inhibitor

A technology of proton pump inhibitors and oryzanol, which is applied in drug combination, pill delivery, pharmaceutical formulation, etc.

Inactive Publication Date: 2013-04-17
BEIJING KEYUAN CHUANGXIN TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the fact that the formation of peptic ulcer is caused by organic factors of excessive gastric acid secretion and abnormal gastric acid factors caused by autonomic nerve disorders caused by mental factors such as mental anxiety, there are no clinical reports on the combination of proton pump inhibitors and autonomic nerve regulation. oryzanol combined application

Method used

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  • Composition of oryzanol and proton pump inhibitor
  • Composition of oryzanol and proton pump inhibitor
  • Composition of oryzanol and proton pump inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Proton pump inhibitor and oryzanol compound double-layer tablet

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Embodiment 2

[0027] Example 2 Proton pump inhibitor and oryzanol compound bilayer tablet

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Embodiment 3

[0032] Example 3 Proton pump inhibitor and oryzanol compound bilayer tablet

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PUM

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Abstract

The invention provides a composition of oryzanol and a proton pump inhibitor. The composition includes a clinical effective dose of proton pump inhibitor and an effective dose of oryzanol which are existent in different drug release units respectively; in a unit preparation, the clinical effective dose of proton pump inhibitor is 10-100 mg and the effective dose of oryzanol is 100-500 mg; the proton pump inhibitor in the composition is selected from omeprazole, lansoprazole, pantoprazole, rabeprazole, esomeprazole or pharmacologically suitable racemes, alkaline salt forms or single corresponding isomer forms thereof; and the drug release unit where the proton pump inhibitor is also includes an alkalizer. The composition can be used for treating peptic ulcer.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a compound composition of a proton pump inhibitor and oryzanol and the application of the compound composition in the field of medicine. Background technique [0002] Peptic ulcer mainly refers to gastric ulcer and duodenal ulcer. Peptic ulcer is a multi-etiological disease, and its formation is caused by various factors: excessive gastric acid secretion, Helicobacter pylori (HP) infection, weakened protective function of gastric and duodenal mucosa, gastric and duodenal dysfunction and Bile reflux, as well as mental factors such as mental stress and anxiety caused by stress in life also account for a large proportion, and are also affected by genetic factors, diet, drugs, and smoking. Most peptic ulcer patients have typical clinical manifestations, such as chronic, periodic, and rhythmic epigastric pain. Other gastrointestinal symptoms and syste...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/575A61K9/20A61P1/04
Inventor 武宏伟
Owner BEIJING KEYUAN CHUANGXIN TECH
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