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Cefaclor oral instant film preparation and preparation method thereof

A technology of oral instant film and cefaclor, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of limited drug efficacy and low bioavailability, and achieve rapid Portable, high bioavailability, good taste effect

Inactive Publication Date: 2013-04-17
于晓勇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When taking it, it needs to be taken with water, which is very inconvenient for patients with dysphagia such as children and the elderly
And because cefaclor is stable to gastric acid, the bioavailability is low, so the efficacy is limited

Method used

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  • Cefaclor oral instant film preparation and preparation method thereof
  • Cefaclor oral instant film preparation and preparation method thereof
  • Cefaclor oral instant film preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] prescription:

[0028]

[0029] In this embodiment, the main drug is cefaclor, the polymer film-forming agent is polyvinylpyrrolidone and hydroxyethyl cellulose, polyethylene glycol 400 is a plasticizer, anion exchange resin, menthol and sucralose are masking agents. Flavor agent, FD&C edible red coloring No. 40 is used to increase the appearance aesthetic feeling of film.

[0030] The preparation process of the present embodiment is carried out through the following steps:

[0031] 1. Dissolve 15 g of cefaclor as the main ingredient in the above prescription in 1800 g of 40 °C water, add anion exchange resin, and stir for 24 hours;

[0032] 2. Remove moisture by suction filtration under reduced pressure to make cefaclor / anion exchange resin compound;

[0033] 3. 10.4 g polyvinylpyrrolidone, 20.7 g polyethylene glycol 400 and 11.3 g hydroxyethyl cellulose were added to 180 g 40 ° C of water and stirred for 2 hours as the above-mentioned auxiliary materials; an aque...

Embodiment 2

[0042] prescription:

[0043]

[0044]

[0045] The preparation process of this example is the same as that of Example 1, and the thickness of the finally obtained film is 50 microns. Cut into small pieces with a length of 25mm and a width of 15mm, and the weight of each film is 75mg.

Embodiment 3

[0047] prescription:

[0048]

[0049] The preparation process of this example is the same as that of Example 1, and the thickness of the finally obtained film is 50 microns. Cut into small pieces with a length of 25mm and a width of 15mm, and the weight of each film is 75mg.

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Abstract

The invention discloses a cefaclor oral instant film and a preparation method thereof. The instant film comprises a main drug of an effective dose of a drug and auxiliary materials, wherein the main drug is cefaclor, and the auxiliary materials include a water-soluble polymer, a plasticizing agent, a taste masking agent and an edible colourant. The preparation method comprises the steps of mixing the main drug cefaclor, the taste masking agent and anion exchange resin into water to form uniform dispersion liquid, filtering and removing moisture to prepare a cefaclor / anion exchange resin compound, dispersing the compound and other auxiliary materials into the water to prepare a stable dispersion solution, adopting a solution coating method, using a coater to coat the dispersion solution on a polyester stripping film or a release paper surface to form the film, drying in an airblast oven at 50 DEG C-80 DEG C, and cutting the drug film into a specific size. The instant film can be dissolved in an oral cavity within 5-60 seconds, so that the bioavailability of the cefaclor, namely an effective drug ingredient, is improved greatly, and an effect is exerted quickly.

Description

technical field [0001] The invention relates to an oral pharmaceutical preparation of antibacterial drugs and a preparation method thereof, in particular to a cefaclor oral instant film preparation and a preparation method thereof. Background technique [0002] Cefaclor is a semi-synthetic oral cephalosporin with broader antibacterial properties than other first-generation cephalosporins. The activity against penicillinase-producing Staphylococcus aureus, group A hemolytic streptococcus, viridans and Staphylococcus epidermidis is the same as that of cephalexin, and its antibacterial effect against non-enzyme-producing Staphylococcus aureus and pneumococcus is stronger than that of cefadroxil 2 to 4 times. The activity against Gram-negative bacilli, including Escherichia coli and Klebsiella pneumoniae, is stronger than cephalexin, similar to cefadroxil, and the activity against Proteus mirabilis, Salmonella and Shigella is stronger than cefadroxil . Moraxella catarrhalis a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/545A61K47/38A61P31/04
CPCY02A50/30
Inventor 于晓勇
Owner 于晓勇
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