Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Sterile bovine colostrum whey with natural immunocompetence and preparation method and application thereof

A technology of natural immunity and colostrum, applied in whey, application, dairy products, etc., can solve the problems of immunoglobulin retention, product irritating odor, membrane pore blockage, etc., achieve high immunoglobulin content and maintain natural activity , the effect of preventing pore clogging

Active Publication Date: 2013-04-17
HEILONGJIANG KANPURE BIOTECH
View PDF5 Cites 23 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Although radiation sterilization can denature bacterial proteins, it will also cause denaturation of some immunoglobulins in bovine colostrum. This method will also cause the product to produce a pungent odor
3. Although ultra-high pressure sterilization technology can retain the activity of functional components, it has no obvious effect on killing bacterial spores, and it is difficult to make the product reach a sterile state
4. Directly use ceramic membrane and other microfiltration equipment to sterilize. Impurities such as residual fat and casein particles in bovine colostrum whey will easily block the membrane pores, so the pore size will be further reduced, resulting in the retention of immunoglobulins. Membrane flux will decay quickly, which is not conducive to industrial production
There are great differences in the processing technology of bovine colostrum between domestic and foreign enterprises, but few enterprises can break through the technical barriers of colostrum whey protein loss caused by heat sterilization and membrane technology, and form an industrial scale

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sterile bovine colostrum whey with natural immunocompetence and preparation method and application thereof
  • Sterile bovine colostrum whey with natural immunocompetence and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 6 L of bovine colostrum was placed in a preparative centrifuge at 45°C and 4000 r / min for 20 min to remove fat to obtain 5 L of defatted bovine colostrum. The casein in the skim colostrum was precipitated by the rennet method, that is, heating the skim colostrum to 40°C, adding rennet in a proportion of 0.02% of the weight of the skim milk, stirring evenly, and allowing the casein to coagulate. Cut the coagulated casein into blocks of 1-2 cm, filter out the crude whey extract, and centrifuge at 4000 r / min for 20 min to obtain whey liquid. A 0.4μm hollow fiber membrane is used for pre-filtration to remove residual fat, casein, most of the bacteria and other impurities in the whey, allowing the active ingredients to permeate to obtain a clear whey liquid, the inlet pressure is 1.0bar, and the outlet pressure is 0.1 bar, temperature 20°C. Then, filter sterilization was carried out through a 0.1 μm polytetrafluoroethylene membrane filter. Filled under aseptic conditions, ...

Embodiment 2

[0025] 6 L of bovine colostrum was placed in a preparative centrifuge at 45°C and 4000 r / min for 20 min to remove fat to obtain 5 L of defatted bovine colostrum. The casein in the skim colostrum was precipitated by the isoelectric point method, that is, the pH of the skim colostrum was adjusted to 4.3 with 1M lactic acid, and the whey liquid was obtained by centrifugation after the casein was completely precipitated at 40°C for 20 minutes. A 1.2μm hollow fiber membrane is used for pre-filtration to remove residual fat, casein, most of the bacteria and other impurities in the whey, allowing the active ingredients to pass through to obtain a clear whey liquid. The inlet pressure is 1.0bar and the outlet pressure is 0.1 bar, temperature 20°C. Then, filter sterilization was carried out through a 0.4 μm polytetrafluoroethylene membrane filter. Filled under aseptic conditions, it becomes sterile bovine colostrum whey. The whey liquid is added into milk to obtain a drink with the f...

Embodiment 3

[0027] The bovine colostrum whey powder was dissolved in purified water at 30°C at a concentration of 7%, and stirred for 30 min to obtain a whey liquid. A 1.0 μm ceramic membrane was used for pre-filtration, with an inlet pressure of 0.8 bar and an outlet pressure of 0.4 bar. Then, filter sterilization was carried out through a 0.3 μm polytetrafluoroethylene membrane filter. Filled under aseptic conditions, it becomes sterile bovine colostrum whey. The whey liquid is added to the fruit juice to obtain a drink with the function of enhancing immunity, wherein the mass fraction of the whey liquid added is 20%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Apertureaaaaaaaaaa
Apertureaaaaaaaaaa
Login to View More

Abstract

The invention relates to sterile bovine colostrum whey with natural immunocompetence, and a preparation method and an application thereof. The preparation method comprises the steps of centrifuging bovine colostrum, removing fat to obtain defatted bovine colostrum, settling casein in the defatted bovine colostrum by an isoelectric point method or a chymosin method, obtaining whey liquid, or dissolving bovine colostrum whey powder to obtain the whey liquid, pre-filtering with a hollow fiber membrane or a ceramic membrane, removing the residual fat, casein and most thalli in the whey, conducting filtration sterilization with a polytetrafluoroethylene membrane filter, filling under a sterile condition, and obtaining the sterile bovine colostrum whey. The sterile bovine colostrum whey is degermed by a polytetrafluoroethylene degerming membrane based on pre-filtering, the handling capacity of feed liquid is increased, the service life of the membrane is prolonged, the membrane cost is saved, and the sterile bovine colostrum whey is suitable for industrial production. The content of immunoglobulin in the obtained whey is high; sterile requirements can be met; and the whey can directly serve as an immunoglobulin-rich whey product, and can also be added to beverages such as milk and fruit juice to be made into functional beverages.

Description

technical field [0001] The present invention relates to bovine colostrum whey and a preparation method thereof, in particular to a sterile bovine colostrum whey with natural immune activity, its preparation method and application in preparing functional beverages. Background technique [0002] Bovine colostrum whey is rich in nutrients, immune factors and growth factors, such as immunoglobulins, lactoferrin and proline-rich polypeptides, etc., which have immune regulation, improve gastrointestinal tract and regulate gastrointestinal flora, etc. effect. The following factors should be considered in the production of whey products: 1. Due to the poor heat resistance of the active protein in colostrum, it is not suitable to use the heat treatment process of constant milk, otherwise the denatured protein will coke in the heating equipment, causing Contamination from subsequent production. Immunoglobulins such as sIgA, IgM, IgG, etc. are macromolecular proteins, which are compo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A23C21/00A23C21/06A23C21/08
Inventor 赵红宇周盛华李学琳朱洪艳
Owner HEILONGJIANG KANPURE BIOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com