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Method for preparing drug-loading nanocomposite through ball-milling modification of mineral soil and application

A nano-composite material and mineral technology, which is applied in the field of pesticides and pharmaceuticals, can solve the problems that the efficient utilization of materials cannot be fully reflected, and the drug loading rate of carrier materials cannot be fundamentally improved. The effect of strong adsorption capacity

Active Publication Date: 2013-04-17
HAINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the mechanical properties of the carrier material can be improved by adding bentonite, kaolin, activated carbon, starch and chitosan, etc., and its sustained release performance can be adjusted, the drug loading rate of the carrier material cannot be fundamentally improved.
The efficient use of materials cannot be fully reflected

Method used

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  • Method for preparing drug-loading nanocomposite through ball-milling modification of mineral soil and application
  • Method for preparing drug-loading nanocomposite through ball-milling modification of mineral soil and application
  • Method for preparing drug-loading nanocomposite through ball-milling modification of mineral soil and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Dissolve 1g of sodium alginate in slowly heated distilled water to prepare 50ml of sodium alginate aqueous solution. After it is completely cooled, mix 200mg of pesticides into the aqueous sodium alginate solution and stir vigorously to make it a uniform mixture. Then prepare 100ml of 0.25M calcium chloride aqueous solution, add 2% (w / v) acetic acid and 0.6% (w / v) CS respectively, stir and mix thoroughly. Finally, the above-mentioned polymer mixture was dripped dropwise into the calcium chloride-chitosan mixed solution with a 25mL hypodermic syringe at a height of 30cm and stirred at a constant speed. After 30 min, the beads were transferred from the gelling agent, filtered and rinsed with distilled water. Dry at room temperature for a while, and finally transfer to an oven to dry at 40°C until constant weight. The obtained composite rubber beads loaded with acetamiprid had an encapsulation rate of 42.13% and a drug loading rate of 4.15%. In the 50% methanol solution ...

Embodiment 2

[0038] A preparation method of drug-loaded nanocomposite rubber beads comprises the following two processes:

[0039] (1) Drug loading: Put 2 g of kaolin and 0.12 g of hydrogen-containing silicone oil into the tank of the planetary ball mill. Equipped with 1 steel ball in the tank 6 pieces 20 pieces The rotating speed of the main disk is controlled at 516r / min, and the ball milling is performed for 2 hours. Take 1.5g of modified kaolin, 0.5g of cetyltrimethylammonium bromide, 200mg of acetamiprid and 100ml of deionized water, mix together and ultrasonically disperse for 30min. Then the mixed solution is frozen into blocks in a refrigerator, placed in a freeze dryer to continue freezing, vacuumized and dried to obtain the drug-loaded mineral soil.

[0040] (2) Prepare dosage form: Dissolve 1g of sodium alginate in slowly heated distilled water to obtain 50ml of sodium alginate aqueous solution. After it is completely cooled, mix the drug-loaded mineral soil into the aqueo...

Embodiment 3

[0042] A preparation method of drug-loaded nanocomposite rubber beads comprises the following two processes:

[0043] (1) Drug loading: respectively put 2 g of montmorillonite, 0.08 g of cetyltrimethylammonium bromide, 2 g of kaolin and 0.12 g of hydrogen-containing silicone oil into two tanks in the planetary ball mill. Each tank is equipped with 1 steel ball 6 pieces 20 pieces The rotating speed of the main disk is controlled at 516r / min, and the ball milling is performed for 2 hours. Take 1.25g of modified kaolin, 0.25g of montmorillonite, 0.4g of cetyltrimethylammonium bromide, 200mg of acetamiprid and 100ml of deionized water, mix together and ultrasonically disperse for 30min. Then the mixed solution is frozen into blocks in a refrigerator, placed in a freeze dryer to continue freezing, vacuumized and dried to obtain the drug-loaded mineral soil.

[0044] (2) Prepare dosage form: Dissolve 1g of sodium alginate in slowly heated distilled water to obtain 50ml of sod...

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Abstract

The invention relates to a method for preparing drug-loading nanocomposite through ball-milling modification of mineral soil and blending modification. A preparation method of a novel controlled-release pesticide high-load rate carrier is characterized by comprising the steps of 1) performing ball-milling modification on montmorillonite and kaolin respectively by taking hexadecyl trimethyl ammonium bromide and hydrogen-containing silicone oil as modifiers, and mixing the modified montmorillonite and kaolin at certain proportion; 2) dissolving acetamiprid with water and performing ultrasonic dispersion, and loading the suspension of acetamiprid to the modified mineral soil through a 'negative pressure-freeze-drying method'; and (3) mixing and stirring a sodium alginate solution and the drug-loading mineral soil to obtain a sol system, and dripping the sol system into a chitosan-containing calcium chloride gelling agent by using an injector, and performing crosslinking to obtain alginate / mineral soil / chitosan drug-loading nanocomposite pellets. By using the film forming property of chitosan and the characteristics of the modified mineral soil, the system provided by the invention improves the stability and drug loading ratio of material, and also can adjust the release of drug and improve the mechanical strength. The novel controlled-release pesticide carrier provided by the invention can reduce influence of the environmental factors such as leaching, evaporation, degrading and the like, prolongs the duration of pesticide effect, and reduces the application amount of agricultural pesticide.

Description

technical field [0001] The invention belongs to the technical field of pesticide pharmacy, and in particular relates to a method for ball-milling modified mineral soil and preparing a drug-loaded nanocomposite material through blending modification. Background technique [0002] Traditional pesticides are easily affected by environmental factors such as leaching, evaporation, and degradation, so their utilization rate is often only 20% to 30%. The loss rate through various channels is as high as 50% to 60%. This is not only economically a waste, but also causes a large area of ​​environmental pollution. With the development of society, human beings' awareness of environmental protection has gradually increased, and the living environment has been valued. Green agriculture is the future development direction of agriculture and the only way to make my country's agriculture sustainable. Controlling the release quantity, release time and release space has become an important d...

Claims

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Application Information

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IPC IPC(8): A01N25/08A01N47/40
Inventor 李嘉诚林强颜慧琼冯玉红胡文涛程春凤刘若林王春修
Owner HAINAN UNIVERSITY
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