Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Hard tissue repair and substitute material and preparation method thereof

A technology of hard tissue and ceramics, which is applied in the field of hard tissue repair and replacement materials and its preparation, can solve the problems of bone repair and replacement material structural support clinical application constraints, and the low mechanical strength of single dual-phase calcium-phosphorus ceramics. The effect of promotion and application value, low cost and strong practicability

Inactive Publication Date: 2013-04-03
CHONGQING MEDICAL UNIVERSITY
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The invention provides a hard tissue repair and replacement material and a preparation method thereof, aiming at solving the problem that the mechanical strength of single dual-phase calcium-phosphorus ceramics is low, it is difficult to play a structural support role as a bone repair and replacement material, and clinical application is limited. greatly constrained problem

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hard tissue repair and substitute material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0014] The preparation method comprises the following steps:

[0015] In step S101, 63.16g 6-aminocaproic acid, 2.76g proline, 2.68g alanine, 2.96g phenylalanine, 1.8g lysine, 3.00g hydroxyproline and 100ml water were added to 250ml in a three-necked bottle with stirring device and nitrogen protection device;

[0016] In step S102, nitrogen protection and stirring are turned on, and the temperature is gradually raised to 200°C. After the dehydration is completed, the temperature is raised to 210°C. At this temperature, all the reactants are melted into a bright yellow and transparent melt;

[0017] In step S103, after the monomer is melted, the temperature is raised to 220°C to start the polymerization reaction for 3 hours, and 49.89 g of biphasic calcium phosphate ceramics with a content of 40% is added, and the temperature is raised to 230°C to react for 3 hours. After the reaction is completed, under the protection of nitrogen Cool to room temperature to obtain massive har...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of a biological material and provides a hard tissue repair and substitute material and a preparation method thereof. The hard tissue repair and substitute material comprises biphasic calcium phosphate (BCP) in which polyamino acid (PAA) is added. The hard tissue repair and substitute material with good biological activity and enough mechanical strength is obtained by adding the polyamino acid to improve the mechanical strength of the biphasic calcium phosphate, thereby the problem that the single biphasic calcium phosphate has lower mechanical strength, is difficult to serve as the bone repair and substitute material to play a role in a structural support and is largely restricted in clinical application is solved. The preparation method is simple and lower in cost and has stronger practical applicability and higher popularization and application value.

Description

technical field [0001] The invention belongs to the technical field of biological materials, in particular to a hard tissue repair and replacement material and a preparation method thereof. Background technique [0002] At present, there are many kinds of biomaterials for hard tissue repair and replacement, but few of them can be successfully used clinically. The main reason is that the biological activity and mechanical strength of biomaterials cannot be well balanced, especially in terms of mechanical strength. to the requirements of clinical application. Biphasic calcium phosphate ceramics (biphasic calcium phosphate, BCP) is a biologically active material composed of hydroxyapatite and β-tricalcium phosphate, which combines the high strength, high biological activity and stability of hydroxyapatite (HA) BCP has been extensively researched and widely used as a bone repair material for a long time because of its unique properties and the absorption and degradation propert...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/18A61L27/12
Inventor 蒋电明谯波李鸿严永刚曹侠郝新彦
Owner CHONGQING MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com