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Preparation method and application of sustained-release nanoparticle preparation for preventing and treating grape ulcer

A technology of grape canker and nano-microspheres, which is applied in the field of pesticides, can solve the problems of affecting grape yield and quality, poor permeability of grape branches, and difficult to cure grape canker, so that it is not easy to be damaged by environmental factors and microorganisms, loss, and masking Bad smell, effect of solving selling control problems

Inactive Publication Date: 2013-04-03
INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mainly damage grape shoots, fruit ears, and branches, causing the shoots to die or fail to mature, withered tops, rotten ears, canker spots on the branches, browning of the xylem, resulting in weakening of the tree and loss of fruit; when the disease is severe, it directly leads to plant death , affecting grape yield and quality
[0003] At present, the prevention and treatment methods of grape canker mainly include agricultural control and chemical control. Agricultural control includes methods such as controlling yield and treating wounds after branch pruning; the main agents for chemical control of grape canker are flusilazole and fludioxonil, but due to the Poor permeability to grape branches, the agent is only effective on the pathogenic bacteria on the epidermis of the branches, but not on the pathogenic bacteria that penetrate into the xylem, which leads to the problem that grape canker is difficult to cure

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Add 0.2% flusilazole and other drugs (a.i.) to the dichloromethane solution containing 1%-5% chitosan-polylactic acid copolymer (CS-co-PLA) (flusilazole and other drugs The mass ratio of CS-co-PLA and CS-co-PLA is 1:5), and the solution A is obtained by ultrasonically dissolving completely.

[0031] 2. Dissolve 1% PVA in water to prepare solution B.

[0032] 3. Add B dropwise to A (the volume ratio of A and B is 1:10), stir at a speed of 500r / min for 10min, and quickly ultrasonically crush the mixture for 5min to obtain an O / W emulsion, and then rotatively evaporate the emulsion The organic solvent is removed to prepare 280nm flusilazole and other drug nano-microsphere preparations with a drug load of 30%.

Embodiment 2

[0034] 1. Add 0.01% of flusilazole and other drugs (a.i.) to the dichloromethane solution containing 1%-5% chitosan-polylactic acid copolymer (CS-co-PLA) (flusilazole and other drugs The mass ratio of CS-co-PLA and CS-co-PLA is 1:100), and the solution A is obtained by ultrasonically dissolving completely.

[0035] 2. Dissolve 1% PVA in water to prepare solution B.

[0036] 3. Add B dropwise to A (the volume ratio of A and B is 1:10), stir at a speed of 500r / min for 10min, and quickly ultrasonically crush the mixture for 5min to obtain an O / W emulsion, and then rotatively evaporate the emulsion The organic solvent is removed to prepare 180nm flusilazole and other drug nano-microsphere preparations with 10% drug loading.

Embodiment 3

[0038] Inhibitory effect of flusilazole and fludioxonil sustained-release nano-microsphere preparations on grape canker at a concentration of 200mg / L.

[0039] The flusilazole and fludioxonil nano-microsphere preparations of the present invention have obvious inhibitory effect on grape canker bacterium, and after testing, the inhibitory effect is as high as 90%, which is significantly better than the current conventional medicament (such as 40% flusilazole emulsifiable oil antibacterial Effect 81% and 50% fludioxonil wettable powder antibacterial effect 85% etc.).

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Abstract

The invention relates to a preparation method and application of a sustained-release nanoparticle preparation for preventing and treating grape ulcer, belonging to the technical field of pesticides.

Description

technical field [0001] The invention relates to the preparation and application of a slow-release nano-microsphere preparation for preventing and treating grape canker, and belongs to the technical field of pesticides. technical background [0002] Grape canker is a disease caused by fungi of the genus Botryosphaeria spp., which is an important grape disease found in the world in recent years. Mainly damage grape shoots, fruit ears, and branches, causing the shoots to die or fail to mature, withered tops, rotten ears, canker spots on the branches, browning of the xylem, resulting in weakening of the tree and loss of fruit; when the disease is severe, it directly leads to plant death , affecting grape yield and quality. [0003] At present, the prevention and treatment methods of grape canker mainly include agricultural control and chemical control. Agricultural control includes methods such as controlling yield and treating wounds after branch pruning; the main agents for c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N55/10A01N43/50A01N43/36A01N25/10A01N25/18A01P3/00
Inventor 王忠跃梁艳辉梅向东宁君
Owner INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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