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Gastrodin compound and medicine composition thereof

A technology of gastrodin and its compounds, which is applied in the field of gastrodin compounds and their pharmaceutical compositions, can solve the problems of poor storage stability of preparations, loss of active ingredients, and reduced curative effect, and achieve good stability, low volatility, and storage stability Good results

Inactive Publication Date: 2013-03-13
北京康瑞达彤科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Gastrodin is a volatile oil, and the characteristic of volatile oil is that it is easy to volatilize when exposed to high temperature. Therefore, no matter whether Gastrodia elata is fried together or separately, the active ingredients will be lost due to high temperature, and the longer the frying time, the more active ingredients will be lost. , thereby reducing the curative effect. Although gastrodin is extracted from Gastrodia elata in the pharmaceutical field and made into various dosage forms for use by patients, gastrodin has poor storage stability due to its volatility

Method used

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  • Gastrodin compound and medicine composition thereof
  • Gastrodin compound and medicine composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Preparation of gastrodin crystals:

[0045] Take Gastrodia elata powder 100g, add 40% ethanol solution, the liquid-solid ratio is 20ml / g, adjust the pH to 4, put it in a microwave equipment, the microwave power is 300W, the temperature is 35°C, the extraction time is 4 minutes, filter, and Concentrate the filtrate into an extract; add 10ml of ether, stir for 5min, discard the ether and dry to obtain crude gastrodin;

[0046] According to the amount of 3ml mixed solution added to 1mg gastrodin crude product, add the mixed solution of ethanol and ethyl acetate to the gastrodin crude product, wherein the volume ratio of ethanol and ethyl acetate is 2:1, adjust the pH to 6, and then add Activated carbon, the weight of activated carbon is 0.1 times that of the crude gastrodin, stirred for 40min, decarburized and sterilized by filtration to obtain a clarified solution, and the solution was flowed through a 0.5T DC magnetic field at a speed of 7m / s, and the direction of the ma...

Embodiment 2

[0049] Preparation of gastrodin crystals:

[0050] Take Gastrodia elata powder 100g, add 50% ethanol solution, the liquid-solid ratio is 15ml / g, adjust the pH to 5, put it in a microwave equipment, the microwave power is 300W, the temperature is 35-40°C, the extraction time is 10 minutes, filter , the filtrate was concentrated into an extract; 15ml of ether was added, stirred for 10min, the ether was discarded and dried to obtain crude gastrodin;

[0051] According to the amount of 4ml mixed solution added to 1mg gastrodin crude product, add the mixed solution of ethanol and ethyl acetate to the gastrodin crude product, wherein the volume ratio of ethanol and ethyl acetate is 3:1, adjust the pH to 5, and then add Activated carbon, the weight of activated carbon is 0.3 times the crude product of gastrodin, stirred for 20min, filtered for decarburization and sterilized to obtain a clarified solution, and the clarified solution was flowed through a 0.5T DC magnetic field at a spe...

Embodiment 3

[0054] Gastrodin Dispersible Tablets

[0055] Take 100 g of gastrodin crystals prepared in Example 1, 20 g of low-substituted hydroxypropyl cellulose, 180 g of microcrystalline cellulose, and 30 g of cross-linked polyvinylpyrrolidone, mix well, use 95% ethanol as a wetting agent to granulate, and dry at 60°C , the whole grain; after the inspection is qualified, it is pressed into 1000 pieces and packaged separately.

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Abstract

The invention relates to the field of medicines, and particularly relates to a gastrodin compound. The gastrodin compound provided by the invention is a crystal, and the X-ray powder diffraction obtained via a measurement adopting a Cu-K(alpha) ray, of the gastrodin compound, shows characteristic peaks at places having angles 2*theta of 9.4 degrees, 9.9 degrees, 15.1 degrees, 15.6 degrees, 18.4 degrees, 22.5 degrees, 25.6 degrees, 27.9 degrees, 28.6 degrees, 29.1 degrees, 30.5 degrees, 30.9 degrees, 31.5 degrees, 32.6 degrees, and 32.7 degrees+ / -0.2 degrees. The gastrodin compound is high in lattice energy and good in stability, thus greatly improving medication safety. Additionally, the invention further provides a preparation method for the gastrodin compound, and a medicine composition containing the gastrodin crystal. The gastrodin medicine composition provided by the invention is good in storage stability and higher in safe performance.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a gastrodin compound and a pharmaceutical composition thereof. Background technique [0002] Gastrodin, also known as gastrodin, the English name is Gastrodin, CAS: 62499-27-8, molecular formula: C13H18O7, molecular weight: 286.28, English chemical name: 4-(hydroxymethyl)phenyl-β-D-Glucopyranoside, Chinese chemical name 4- Hydroxymethylphenyl-β-D-glucopyranoside, the structural formula is: [0003] [0004] Gastrodia elata raw material is mainly produced in Yunnan Province of my country. It is a sedative, hypnotic and anticonvulsant drug extracted from the dry root of Gastrodia elata, a plant of the genus Orchidaceae. It is a white crystalline powder at room temperature. p-Hydroxymethylbenzoic acid aglycone. It can restore the imbalance between the excitation and inhibition of the cerebral cortex, and has good antihypertensive, sedative, and hypnotic effects. It has certain curative e...

Claims

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Application Information

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IPC IPC(8): C07H15/203C07H1/08A61K31/7034A61P25/20A61P25/08A61P25/00A61P9/12A61P9/08
Inventor 罗军徐丹周平
Owner 北京康瑞达彤科技有限公司
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