A kind of benzimidazole pyridine complex and preparation method thereof

Abstract

The invention discloses a benzimidazole pyridine complex and a method for preparing the same. The method is that Pb(NO3)2, 2, 6-bisbenzimidazole pyridine (bbp) and 5-nitroisophthalicacid (nipa) are proportionally weighed according to the molar ratio of 1:1:(1-0.5) to be put into a container and are added with water to be stirred for 10-15 minutes; then, the stirred raw material liquid is poured into a reactor, the reactor is covered to be heated to 160-165 DEG C, and then, thermal insulation reaction is carried out for 115-120 hours; and a gradient heating method is adopted to cool the raw material liquid to room temperature so as to obtain a colorless blocky crystal complex, i.e. the benzimidazole pyridine complex [Pb2(nipa) (Hbbp)2]n.nH2O is obtained. The benzimidazole pyridine complex has the characteristics of good stability and obvious functions in inhibiting three types of human cancer cells of human breast cancer cells, lung cancer cells and cervical cancer cells, and provides guidance for the research and development of an anticancer complex.

Description

technical field [0001] The invention belongs to anticancer compounds, in particular to a benzimidazolpyridine complex and a preparation method thereof, and its application as an antitumor compound. Background technique [0002] Malignant tumors are a large class of diseases that seriously threaten human health. Their abnormal proliferation is controlled by abnormal information in cells and is closely related to the abnormal activity and inactivation of corresponding genes in tumor cells. Common malignant tumors in my country include: lung cancer, gastric cancer, esophageal cancer, colon cancer, liver cancer, cervical cancer, breast cancer, leukemia, malignant lymphoma, nasopharyngeal cancer and other ten tumors. Among them, lung cancer, gastric cancer, esophageal cancer, liver cancer, breast cancer, and cervical cancer are the most common, accounting for about 70% to 80% of all malignant tumors. [0003] The current clinical treatment of tumors includes surgery, radiotherap...

AI Technical Summary

Problems solved by technology

[0003] The current clinical treatment of tumors includes surgery, radiotherapy, and chemotherapy. Most of the drugs currently used for treatment are chemical drugs. Although they can relieve symptoms and prolong the course of the disease, there are still many problems: especially because chemotherapy drugs are highly toxic Tumor cells also damage the body's own immune cells such as white blood cells and lymphocytes, resulting in patients often being infected concurrently due to low autoimmunity, and the virus in the body cannot be completely cleared, drug withdrawal rebounds, prone to adverse reactions, large toxic and side effects, and a long course of treatment , the cost of treatment is expensive, making it unaffordable for many patients

At the same time, cancer cells often develop drug resistance when exposed to sublethal concentrations of chemotherapy drugs, and often cross-resistance to other anti-tumor drugs. to the desired effect

Images