Preparation method of compound bismuth aluminate tablet

Abstract

The invention discloses a preparation method of a compound bismuth aluminate tablet. The preparation method comprises the steps of: weighing and mixing 100-300g of bismuth aluminate, 350-600g of heavy magnesium carbonate, 50-400g of sodium bicarbonate, 150-450g of licorice extract powders, 10-40g of buckthorn bark powders, 10-500g of filling diluent and 10-100g of disintegrating agent to obtain a mixture A; spraying 10-300g of adhesive in an atomization state and in a specific shape into the mixture A; pelletizing by a wet method; sifting with a sieve of 10-24 meshes; straightening particles; drying the particles till the water content is 1-7%; sifting with a sieve of 10-24 meshes; straightening particles to obtain particles A, wherein the specific shape of the adhesive in the atomization state is a sector of 0-180 degrees, a hollow cone, a solid cone or a solid square; uniformly mixing particles A, 1-30g of fennel powders and 5-25g of lubricants; tabletting; and packaging a product to obtain a finished product. According to the preparation method of the compound bismuth aluminate tablet, the safety is good, the productivity is high, the quality is stable and controllable and the effectiveness and the safety of the compound bismuth aluminate tablet can be guaranteed effectively.

Description

technical field [0001] The invention relates to a preparation method of a pharmaceutical preparation, in particular to a preparation method of compound bismuth aluminate tablets. Background technique [0002] The main ingredients of compound bismuth aluminate tablets are bismuth aluminate, heavy magnesium carbonate, sodium bicarbonate, licorice extract powder, buckthorn bark powder and fennel powder, etc. Burning sensation (heartburn), acid reflux, and also for chronic gastritis. Compound bismuth aluminate tablet is a compound preparation, and the bismuth aluminate contained in it can form a protective film on the gastric and duodenal mucosa. Sodium bicarbonate and heavy magnesium carbonate have obvious antacid effects. Cascara bark and fennel are compounded to neutralize gastric acid, eliminate flatulence and constipation, strengthen the gastric and duodenal mucosal barrier, regenerate the mucosa, and promote the healing of ulcers. Through years of clinical use, it has be...

AI Technical Summary

Problems solved by technology

In the production process, even though the whole production line adopts explosion-proof equipment, the use of flammable and explosive high-concentration ethanol solution greatly reduces the safety of the production of compound bismuth aluminate tablets, which brings hidden dangers to the safe production of enterprises

However, even if a high-concentration ethanol solution preparation process is used, due to the limitations of the preparation process, the defects of the prepared particles lead to large fluctuations in the tablet weight of the compound bismuth aluminate tablets during high-speed tableting, which in turn leads to large fluctuations in the content of the finished product. As a result, the product cannot be compressed at high speed

Therefore, the single-day production capacity of the production and preparation process of compound bismuth aluminate tablets high-concentration ethanol solution cannot meet people's demand for this drug and will bring greater risks to people's drug safety.

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