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Degradable magnesium alloy esophageal stent for infants

A magnesium alloy, infant technology, applied in the field of medical devices, can solve the problems that the strength and duration cannot meet the infant esophageal stent, the shape and structure information of the magnesium alloy stent is not disclosed, and the structural information of the esophageal stent is not disclosed, so as to prevent Migration or slippage, great toughness and plasticity, effect of reducing corrosion

Inactive Publication Date: 2013-03-13
SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent document application number 201110136252.3, publication number CN102274093A, discloses a medical magnesium alloy stent and its processing method. The medical magnesium alloy stent is obtained by subjecting the magnesium alloy to micro-arc oxidation treatment, nickel-plating pre-treatment and nickel-plating treatment. There is a double-layer composite anti-corrosion film on the surface of the alloy, and the outer layer of the micro-arc oxidation film is a loose porous structure, and the chemical plating layer grows in situ on the surface of the micro-arc oxidation film; the chemical plating layer is closely combined with the micro-arc oxidation film layer with a loose porous structure Together, the corrosion resistance of the magnesium alloy stent is greatly improved, but the shape and structure information of the magnesium alloy stent is not disclosed
[0005] Chinese patent document application number 200310107965.2, publication number CN1528252A, discloses a degradable composite artificial esophagus and its preparation method. The polyurethane / collagen / chitosan degradable composite artificial esophagus is composed of two layers, and the inner layer is made of polyurethane material. The inner tube, the outer layer is cross-linked collagen-chitosan sponge, the stent is a non-metallic esophageal stent, and its strength and duration cannot meet the requirements of infant esophageal stents
Chinese patent document application number 201110020719.8, publication number CN102071491A, discloses a medical esophageal stent fiber and its preparation method, and prepares polydioxanone (PPDO) fibers that meet the requirements by melt spinning. PPDO fibers are non-toxic, non-toxic Stimulation, high mechanical support strength, good biodegradability, biocompatibility and processability, but the structural information of the esophageal scaffold made of this fiber is not disclosed
At present, degradable magnesium alloy materials have been used to manufacture tracheal stents, but there are no reports on magnesium alloy esophageal stents applied to infants

Method used

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  • Degradable magnesium alloy esophageal stent for infants
  • Degradable magnesium alloy esophageal stent for infants
  • Degradable magnesium alloy esophageal stent for infants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Preparation of Magnesium Alloy Wire

[0039] The preparation process of the magnesium alloy metal wire used in the present invention: (1) Extrude the Mg-Nd-Zn-Zr magnesium alloy ingot with a length of Φ90mm and a length of 300mm at 400°C to form a wire rod of Φ8mm, and then anneal at 300°C for 30 Minutes to remove the stress of extrusion processing; (2) Pull the Φ8mm magnesium alloy wire rod on the drawing machine for multiple passes, and the diameter reduction of each pass is 20%, until the diameter is reduced to Φ3mm, each drawing Once, carry out a stress relief annealing, the annealing process is 300 ℃, 30 minutes; (3) continue to draw the Φ3mm Mg-Nd-Zn-Zr magnesium alloy wire, and the diameter reduction of each drawing is 10 %, until the diameter is reduced to 0.5mm, a stress relief annealing is performed after each drawing pass, and the annealing process is the same as before.

[0040] Magnesium alloy wires with a diameter of 0.5 mm were braided into the required ...

Embodiment 2

[0043] Degradable infant magnesium alloy esophageal stent (1).

[0044] Please refer to figure 1 , figure 1 It is the expanded view of the ring-shaped monomer of the degradable magnesium alloy esophageal stent for infants. It can be seen from the figure that the ring-shaped unit 1 is folded in a W shape by a magnesium alloy wire, and has a plurality of bends 11 . The closed connection of the metal wire can form a cylindrical ring-shaped monomer 1, and there are 10 bending places 11 at both ends thereof. The ring-shaped monomer 1 has toughness and deformability, and given a certain radial pressure, the diameter of the ring-shaped monomer 1 will shrink and its length will increase. The diameter of the magnesium alloy wire is 0.5mm.

[0045] Please refer to figure 2 , figure 2It is a structural schematic diagram of a degradable magnesium alloy esophageal stent for infants. The esophageal stent is composed of six ring-shaped monomers 1, and adjacent ring-shaped monomers 1...

Embodiment 3

[0049] Degradable infant magnesium alloy esophageal stent (2).

[0050] The degradable infant magnesium alloy esophageal stent is composed of three ring-shaped monomers 1, the length of the stent is 10 mm, and the inner diameter of the stent is 4 mm. The diameter of the magnesium alloy metal wire is 0.4mm. The ring-shaped monomer 1 is folded in a W shape by the magnesium alloy wire, and is closed and connected to form a cylindrical shape. There are 12 bends 11 at one end of the ring-shaped monomer 1. There are 12 connection points 2 for each circle. The protrusion 3 of the esophageal stent is in the shape of a triangular pyramid, that is, a tetrahedron, and its bottom surface is an equilateral triangle. .

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Abstract

The invention discloses a degradable magnesium alloy esophageal stent for infants. The esophageal stent comprises annular single bodies, connecting points and projections, wherein each annular single body is formed in the way that a magnesium alloy metal wire is folded in the shape of W and connected to form a cylindrical shape; the annular single bodies have elasticity; bending parts are formed at the two ends of each annular single body; the annular single bodies are axially connected with one another in series by the connecting points; the bottom of each projection is positioned at each connecting point; the top end of each projection is positioned on the outer side of the esophageal stent; and after the magnesium alloy esophageal stent is expanded and released, the projections can be embedded into the esophageal wall and are used for fixing the stent. The degradable magnesium alloy esophageal stent for infants is formed by connecting a plurality of annular single bodies and the length of the esophageal stent can be determined by the number of the connected annular single bodies, so the requirements of the infants suffering from esophageal stenosis are met; the projections on the outer surface of the stent can be embedded into the inner wall of the esophagus and are used for fixing the stent to prevent the stent from moving or slipping off; and the stent can be degraded and absorbed by a human body and the degradation products have no toxicity, so growth and development of infantile patients are not influenced.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a degradable magnesium alloy esophageal stent for infants. Background technique [0002] Esophageal stenosis in infants and young children is more common after esophageal atresia surgery, as well as reflux esophagitis, erosive damage of esophagus, etc. It usually requires repeated X-ray esophageal dilatation, which is painful for children, and X-ray radiation will also affect the growth and development of children; some children need surgical treatment. [0003] The magnesium alloy absorbable metal stent has good mechanical support performance for a certain period of time, and can be degraded by the body afterward, thereby overcoming the complications caused by the long-term retention of the metal body, and will not affect the growth and development of the child. At the same time, magnesium is an essential trace element in the human body. After degradation, it is effecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/90A61F2/89A61L31/02
Inventor 顾松袁广银
Owner SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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