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Desloratadine oral dispersible film

A desloratadine and film technology, applied in the field of desloratadine orodispersible film, can solve the problems of slow onset of action, inconvenient quantification and carrying, difficult to swallow for the elderly and children, and the like

Inactive Publication Date: 2013-02-27
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The convenient and fast-acting administration method is of great significance for the rapid treatment of cough and phlegm. Oral tablets and dispersible tablets need to be taken with water, and they can only be effective after disintegration and dissolution in the gastrointestinal tract. The onset is slow and inconvenient, so it is difficult to apply The elderly and children who are inconvenient to swallow; the syrup has a quick effect, but it is inconvenient to quantify and carry

Method used

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  • Desloratadine oral dispersible film
  • Desloratadine oral dispersible film
  • Desloratadine oral dispersible film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] prescription:

[0025]

[0026] Process:

[0027] Dissolve the above-mentioned amount of polyethylene glycol 1000 and propylene glycol in the aqueous solution, and then add the prescribed amount of polyvinyl alcohol under stirring state after completely dissolving, and fully stir and disperse to obtain a glue solution. Then add desloratadine and microcrystalline cellulose ph101 and stir evenly. Degas or let stand overnight to remove air bubbles. This glue solution was coated on a PET film. Coating is difficult and uneven, and the film obtained by cutting is white, with good flexibility, slow disintegration, poor taste, and sticky teeth.

Embodiment 2

[0029] prescription:

[0030]

[0031]

[0032] Process:

[0033] (1) Desloratadine is crushed through an 80-mesh sieve.

[0034] (2) Take 150ml of hot purified water, add the prescribed amount of propylene glycol and polyethylene glycol 1000, stir and dissolve in a water bath (70°C). After treating that all dissolve, add the polyvinyl alcohol of 30g to disperse.

[0035] (3) After the polyvinyl alcohol is dispersed and dissolved, add 60ml of hot purified water and stir in a water bath (70°C). And add the remaining polyvinyl alcohol, stir evenly in a water bath at 70°C, cool and stand overnight.

[0036] (4) Take 100ml of purified water and dissolve the prescribed amount of xylitol, microcrystalline cellulose PH101, hydroxypropyl cellulose, rice starch, sucralose, sweet orange essence, and red lake in turn. After being mixed evenly, mix evenly with solution (2).

[0037] (5) Add desloratadine to the uniformly mixed solution, mix uniformly, let stand, and remove air ...

Embodiment 3

[0042] prescription:

[0043]

[0044]

[0045] Process:

[0046] (1) Desloratadine is crushed through an 80-mesh sieve.

[0047] (2) Take 150ml of hot purified water, add the prescribed amount of propylene glycol and polyethylene glycol 400, and stir in a water bath (70°C) to dissolve. After it is completely dissolved, add 30.0 g of low-viscosity hypromellose to disperse.

[0048] (3) After the above-mentioned low-viscosity hypromellose is uniformly dispersed, add 60ml of hot purified water at 70°C, stir in a water bath (70°C), add high-viscosity hypromellose, stir evenly in a water bath at 70°C, and wait for the hypromellose After the cellulose is dissolved. Cool and let stand overnight.

[0049] (4) Take 100ml of purified water and dissolve the prescribed amount of sorbitol, microcrystalline cellulose PH101, hydroxypropyl cellulose, pregelatinized starch, aspartame, strawberry essence, red lake and desloratadine in sequence , mixed with solution (2) evenly.

[0...

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Abstract

The invention relates to a desloratadine oral dispersible film which comprises desloratadine, biologically-acceptable water-soluble polymers, plasticizers, purified water and the like, can be dispersed or dissolved quickly in the oral cavity, and is used for treating allergic rhinitis, allergic rhinitis and asthma syndrome, allergic nasal conjunctivitis, allergic dermatitis, allergic asthma and the like. The desloratadine oral dispersible film is free of irritation, convenient to take and carry, fast in effect, good in taste and particularly suitable for being used by the olds and children.

Description

technical field [0001] The invention relates to a desloratadine oral dispersible film, a preparation method and properties in vitro. The preparation has a beautiful appearance, is convenient to carry, is easy to take, and disintegrates quickly, and can disintegrate in the oral cavity without taking water, and is especially suitable for the elderly, children, and patients who have difficulty swallowing. Desloratadine film is mainly used to relieve the symptoms of allergic rhinitis, and is also used for allergic skin diseases and allergic asthma. Background technique [0002] Allergic rhinitis, allergic rhinitis asthma syndrome, allergic rhinitis-conjunctivitis, allergic skin diseases and allergic asthma, etc., are common clinical diseases, hindering people's normal life, work, study and health. [0003] Desloratadine is the main active metabolite of the second-generation antihistamine Loratadine, and a long-acting tricyclic third-generation antihistamine. Since desloratadine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/4545A61P37/08
Inventor 王丽
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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