Preparation method for compound traditional Chinese medicine preparation children common cold granules

Abstract

The invention provides a preparation method for compound traditional Chinese medicine preparation children common cold granules, and relates to a preparation method for a compound traditional Chinese medicine preparation. The preparation process comprises the following steps: crushing 1 / 5 dose of gypsum and indigowoad root, carrying out vacuum drying, and crushing by using a jet mill to obtain micropowder to provide a spare use; carrying out extraction on rehmannia, blackend swallowwort root and rhizome, Chinese wolfberry root bark, gypsum, chrysanthemum and indigowoad leaf by adopting water as a solvent to obtain a water extract filtrate; carrying out distillation extraction on patchouli, peppermint and weeping forsythia fruit to obtain volatile oil; filtering the residual aqueous solution after volatile oil extraction, and carrying out merging and concentration on the filtered aqueous solution and the water extract filtrate extracted through ultrasonic extraction to obtain an extract to provide a spare use; adopting beta-cyclodextrin to carry out inclusion on the volatile oil extracted through steam distillation extraction to obtain the volatile oil beta-cyclodextrin inclusion complex to provide a spare use; and mixing the traditional Chinese medicine water extraction extract, the traditional Chinese medicine jet milling micropowder, sucrose powder and dextrin to prepare into granules, drying, adding the volatile oil beta-cyclodextrin inclusion complex, and uniformly mixing to obtain the children common cold granules, wherein the children common cold granules have characteristics of fine granule and easy absorption by human bodies, and adverse drug absorption effects on human bodies due to absorption difference are eliminated at a maximum.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine compound preparation, in particular to a preparation process for wind-heat-cold medicine widely used in children with the functions of dispelling wind, relieving exterior syndrome, clearing away heat and detoxifying. Background technique [0002] Xiao'er Ganmao Granule is a traditional Chinese medicine preparation recorded in the Pharmacopoeia of the People's Republic of China. The medicine is a traditional Chinese medicine compound preparation composed of 10 ingredients including patchouli, chrysanthemum, forsythia, Folium Folium, Radix Radix, Rehmannia glutinosa, Digupi, Baiwei, mint and gypsum. Function cures mainly: dispelling wind and relieving exterior syndrome, clearing away heat and detoxicating. For children with wind-heat and cold, symptoms include fever, headache, cough with sticky phlegm, sore throat, and influenza. The current preparation method of Pediatric ...

AI Technical Summary

Problems solved by technology

The above-mentioned preparation methods are all adding Radix Radix Radix and gypsum into the preparation in the form of ordinary powder of the original medicinal material, so that the preparation has the disadvantages of large medicinal material particles, slow action, poor absorption, etc.; and in the above-mentioned preparation method, the volatile oil is all Spray directly on the dry granules, the volatile oil is easy to lose during storage and the strong pungent smell of volatile oil will affect children's intake

In addition, the extraction method of active ingredients of medicinal materials is decocting with water and ordinary concentration, drying and drying. Because the extracts are decocted and dried for a long time, some thermally unstable active ingredients are easily destroyed, and the extraction rate of active ingredients Not high, and long-term heating in the process, which consumes energy and pollutes the environment, is time-consuming and laborious, and is not conducive to the modernization of traditional Chinese medicine production