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Avian colibacillosis treatment traditional Chinese medicine and preparation method thereof

A technology for chicken colibacillosis and traditional Chinese medicine granules, which can be used in pharmaceutical formulations, antibacterial drugs, medical preparations containing active ingredients, etc. , to achieve the effect of not easy to absorb moisture and agglomerate, good therapeutic effect, and low drug cost.

Active Publication Date: 2013-02-13
QINGDAO VLAND BIOTECH INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The repeated outbreaks of Escherichia coli and the poor control effect have greatly restricted the healthy development of the chicken industry and caused serious food safety problems

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The prescription of raw materials is: gypsum 60g; honeysuckle 15g; Scrophulariaceae 12g; skullcap 10g; rehmannia glutinosa 10g; forsythia 8g; gardenia 8g; gentian 8g; sweet ditin 10g; isatis root 12g; anemarrhena 6g; Ophiopogon 6g; sucrose And the right amount of dextrin.

[0032] Granule preparation: crush honeysuckle, scrophulariaceae, and forsythia through 80 mesh sieve, add 0.4g cellulase, add 70ml water, mix well, treat at 50℃ for 15h, then add ethanol to make the alcohol content reach 50% , Heated to reflux for 1h, filtered and concentrated under reduced pressure to obtain concentrated solution A; crush gypsum, scutellaria, radix rehmanniae, gardenia, gentian, dichotoma, Radix isatidis, anemarrhena, and Ophiopogon japonicus through 80 mesh sieve, add 1.3g Cellulase, add 8 times the weight of the medicinal material, mix well, treat for 15h at 50℃, heat and extract for 1h, filter to obtain extract B; mix concentrate A and extract B, and concentrate to relative density ...

Embodiment 2

[0035] The raw material prescription is: gypsum 50g; honeysuckle 10g; scrophulariaceae 10g; scutellaria 8g; rehmannia glutinosa 8g; forsythia 10g; gardenia 10g; gentian 10g; sweet ditin 15g; isatis root 10g; anemarrhena 8g; Ophiopogon japonicus 8g; sucrose And an appropriate amount of soluble starch.

[0036] Granule preparation: crush honeysuckle, scrophulariaceae and forsythia through 65 mesh sieve, add 0.5g cellulase, add 70ml water, mix well, treat at 45℃ for 20h, then add ethanol to make the alcohol content reach 50% , Heated to reflux for 1h, filtered and concentrated under reduced pressure to obtain concentrated solution A; crush gypsum, scutellaria, radix rehmanniae, gardenia, gentian, dichotoma, Radix isatidis, anemarrhena, and Ophiopogon japonicus through 65 mesh sieve, add 1.5g Cellulase, add 6 times the weight of the medicinal material, mix well, treat for 20h at 45℃, heat and extract for 1h, filter to obtain extract B; mix concentrate A with extract B, and concentrat...

Embodiment 3

[0039] The therapeutic effect of the granules prepared in Example 1 on febrile disease caused by E. coli infection in chickens:

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PUM

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Abstract

The present invention discloses traditional Chinese medicine granules for avian colibacillosis treatment, wherein raw materials comprise, by crude drug, 30-90 g of gypsum, 3-20 g of honeysuckle, 2-30 g of figwort root, 2-15 g of baikal skullcap root, 2-15 g of unprocessed rehmannia root, 2-15 g of weeping forsythia fruit, 2-15 g of cape jasmine, 2-15 g of Chinese gentian root, 2-30 g of manyflower gueldenstaedtid herb, 2-40 g of indigowoad root, 2-15 g of common anemarrhena, 2-15 g of creeping liriope, and a proper amount of an excipient. The preparation method for the cooling-relieving therapy granules comprises: (1) adopting enzyme extraction on the drugs in the formula to prepare extract powder, (2) adding the excipient and mixing, and (3) carrying out granulation, drying and sub-packaging to obtain the finished product. The granule agent has functions of heat clearing, detoxication, yin nourishing and dysentery treatment, and has characteristics of high active ingredient content, significant therapy effect, easy taking and no toxic and side-effect.

Description

technical field [0001] The invention belongs to the field of medicaments, and in particular relates to traditional Chinese medicine granules for treating chicken colibacillosis and a preparation method thereof. Background technique [0002] The heat toxicity caused by Escherichia coli in chickens is equivalent to certain types of chicken colibacillosis in veterinary epidemiology. For the convenience of description, it is hereinafter referred to as chicken colibacillosis. [0003] Chicken colibacillosis is caused by avian pathogenic Escherichia coli E. coli , APEC) caused by acute or chronic bacterial infectious diseases, is one of the main diseases affecting the development of chicken industry. Existing surveys and diagnoses have shown that colibacillosis ranks first among bacterial diseases, accounting for 33% of the total cases. The survey of some large chicken farms in Beijing by Liu Guibin and others showed that chicken colibacillosis accounted for 0.94% of the total m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61K9/16A61P31/04A61K33/06
CPCY02A50/30
Inventor 郝智慧王春元庞云露
Owner QINGDAO VLAND BIOTECH INC
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