Preparation technology and production method for integrated new formulation of magnolia bark-ephedra decoction
A production method and a technology for a new dosage form are applied in the field of preparation of a new integrated dosage form of Houpu Mahuang Decoction to achieve the effects of strong sustained and controlled release performance and wide targeted distribution.
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Embodiment 1
[0052] The following raw materials are prepared according to the aforementioned method: extracts, nanoparticles, microcapsules, and nanoparticles.
[0053] The composition of the raw materials used to make the active ingredients is——
[0054] 9 grams of magnolia bark, 12 grams of ephedra, 9 grams of gypsum, 10 grams of almonds, 10 grams of pinellia, 6 grams of dried ginger, 6 grams of asarum, 30 grams of wheat, and 6 parts of schisandra.
[0055] The manufacturing process is as follows: in a GMP10000 class clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed in a ratio of 4:2:2:2, and part of the hard capsules are used in the first part of the "Chinese Pharmacopoeia" of the 2010 edition. Standard, no auxiliary materials and preservatives are added, and hard capsules are filled with automatic capsule filling machines to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, a...
Embodiment 2
[0057] The following raw materials are prepared according to the aforementioned method: water decoction concentrate, nanoliposome, nanoemulsion, and microemulsion.
[0058] The composition of the raw materials used to make the active ingredients is——
[0059] 9 grams of magnolia bark, 12 grams of ephedra, 9 grams of gypsum, 10 grams of almonds, 10 grams of pinellia, 6 grams of dried ginger, 6 grams of asarum, 30 grams of wheat, and 6 parts of schisandra.
[0060] The manufacturing process is as follows: in the GMP 10000 class clean room, the decoction concentrate, nanoliposome, nanoemulsion, and microemulsion are mixed according to the ratio of 4:2:2:2, and the 2010 edition of "Chinese Pharmacopoeia" is used. Part of the preparation is soft capsule standard, no auxiliary materials and preservatives are added, and soft capsules are subpackaged by a fully automatic soft capsule filling machine to make soft capsules. Then carry out internal and external packaging such as countin...
Embodiment 3
[0062] The following raw materials are prepared according to the aforementioned method: extract, nanoparticle, and nanoemulsion.
[0063] The composition of the raw materials used to make the active ingredients is——
[0064] 9 grams of magnolia bark, 12 grams of ephedra, 9 grams of gypsum, 10 grams of almonds, 10 grams of pinellia, 6 grams of dried ginger, 6 grams of asarum, 30 grams of wheat, and 6 parts of schisandra.
[0065] The manufacturing process is as follows: After mixing the extract, nanoparticles, and nanoemulsions in a 4:3:3 ratio in a GMP10000 clean room, the 2010 edition of the "Chinese Pharmacopoeia" Part I of the film preparation standard is used, and the film-forming material is made of Polyvinyl alcohol, made into film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The size of each film is 2-...
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