Quality testing method for compound paracetamol and amantadine hydrochloride granules

Abstract

The invention discloses a quality testing method for compound paracetamol and amantadine hydrochloride granules. The method mainly comprises the steps of appraising the quality of the compound paracetamol and amantadine hydrochloride granules by using a thin layer chromatography method, performing content uniformity measuring and content measuring for acetaminophen, amantadine hydrochloride, caffeine, chlorpheniramine maleate and artificial bezoar by using a liquid chromatography method, measuring the dissolution rate, and measuring the content of bilirubin to achieve the artificial bezoar content measuring. The quality testing method of micro samples of the compound paracetamol and amantadine hydrochloride granules is built, researches on appraisal, content measuring and content uniformity measuring of the compound paracetamol and amantadine hydrochloride granules are achieved, the accuracy is high, good in reproducibility, and the quality of the compound paracetamol and amantadine hydrochloride granules can be controlled comprehensively and effectively, so that clinical effects of the preparation are guaranteed.

Description

technical field [0001] The invention relates to a quality detection method of medicines, in particular to a quality detection method of compound acetaminophen granules. Background technique [0002] Flu is the disease that is caused by virus or bacterium, is a kind of self-healing disease, is divided into common cold and influenza generally. The common cold, called "cold" by traditional Chinese medicine, is a common respiratory disease caused by a variety of viruses, 30%-50% of which are caused by a certain serotype of rhinovirus. Though common cold is mainly in early winter, in any season, as can taking place in spring, summer, the Causative virus of the flu of Various Seasonals is not just the same yet. Influenza is an acute respiratory infectious disease caused by influenza virus. Virus is present in patient's respiratory tract, gives others through droplet infection when patient's cough, sneeze. [0003] At present, in the quality standards of cold medicines that are ...

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Problems solved by technology

[0003] At present, in the quality standards of cold medicines that are widely favored by patients in the market, such as compound acetaminophen tablets, etc., the quality detection methods generally have problems of low accuracy and large errors. For example, the detection of caffeine content uniformity, the general The method is to use the titration method to detect, the accuracy rate is only 80-90%, and the error is relatively large. In addition, the general method for the detection of artificial bezoar is to measure the content of bilirubin or bile acid by ultraviolet spectrophotometry, and there is also an accuracy rate. low problem, moreover, in the general application of high performance liquid chromatography to detect the content, the amount of the sample to be tested needs to be used more, and the trace sample cannot be detected accurately, thus providing a method with high accuracy and reproducibility Good performance, and the quality detection method that can detect trace samples has strong practical significance