Fenbendazole effervescence particle for livestock and poultry and preparation method thereof

Abstract

The invention relates to a fenbendazole effervescence particle for livestock and poultry and a preparation method thereof. The fenbendazole effervescence particle comprises the following raw materials and accessories expressed in weight parts: 30 to 80 parts of fenbendazole, 100 to 140 parts of citric acid, 120 to 170 parts of sodium bicarbonate, 20 to 60 parts of polyethylene glycol 6000, 190 to 260 parts of dextrin and 310 to 390 parts of cane sugar. The preparation method comprises the following steps: respective crushing of the raw materials and the accessories; mixing; granulation; drying; size finishing; and subpackage. The effervescence particle provided by the invention is developed and prepared by using modern detection means and modern pharmaceutical equipment according to GMP standard for veterinary drugs and has the advantages of good curative effects, safety and reliability; the accessories and an effervescent disintegrating agent are added into the raw materials so as to prepare an effervescent granule, and livestock and poultry with diseases take the effervescent granule through oral administration, and good taste, stable quality and improved bioavailability of drugs are realized.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to a fenbendazole effervescent granule for livestock and poultry and a preparation method thereof. Background technique [0002] In the entire veterinary pharmaceutical industry in my country, veterinary drug preparations are a weak link. The existing veterinary drug forms include tablets, oral liquids, injections, etc., which are far from meeting the needs of the absorption and efficacy of certain drugs in veterinary clinics. Therefore, , strengthen the research and development of new dosage forms, realize the characteristics of timing, positioning, fixed speed and continuous action of drugs according to different requirements, continuously improve the curative effect of drugs, and reduce toxic and side effects are our future efforts in research and development of dosage forms. Benzimidazoles are a type of anthelmintic drugs widely used to control nematodes and tapeworms ...

AI Technical Summary

Problems solved by technology

[0002] In the entire veterinary pharmaceutical industry in my country, veterinary drug preparations are a weak link. Existing veterinary drug forms include tablets, oral liquids, injections, etc., which are far from meeting the needs of the absorption and efficacy of certain drugs in veterinary clinics. Therefore, , strengthen the research and development of new dosage forms, realize the characteristics of timing, positioning, fixed speed and continuous action of drugs according to different requirements, continuously improve the curative effect of drugs, and reduce toxic and side effects are the direction of our efforts in the research and development of dosage forms in the future

Benzimidazoles are a type of anthelmintic drugs widely used to control nematodes and tapeworms in livestock and poultry. At present, tablets and injections are mostly used, which causes inconvenience and low absorption effect of livestock and poultry.