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Chinese medicinal composition for treating diabetic nephropathy

A technology of diabetic nephropathy and composition, which is applied in the field of traditional Chinese medicine composition for treating diabetic nephropathy, can solve the problems of obvious side effects, hypoglycemia, high cost, etc., achieve the effect of improving clinical symptoms, reducing urinary protein, and good tolerance

Active Publication Date: 2012-12-26
张定华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, drugs for the treatment of diabetes are divided into three categories: 1. Pure western medicines, which are represented by insulin, sulfonylureas, glinides, biguanides, thiazolidinones, and α-glucosidase inhibitors. Sugar is quick and effective, but the side effects are obvious. Not only does it have the risk of hypoglycemia, but most oral drugs are not suitable for patients with liver and kidney insufficiency, and can cause secondary failure of the patient's drugs; 2. Combination of Chinese and Western medicines, such drugs Because there are western medicine ingredients, there are side effects on liver and kidney function, and long-term use is harmful to the body; 3. Pure Chinese medicine, with pure Chinese medicine, has relatively little toxic and side effects on the human body, and can improve the patient's symptoms as a whole, but the use of decoction is troublesome, and the patient poor dependence
Diabetic nephropathy is one of the chronic microvascular complications of diabetes. Western medicine uses ACEI and / or ARB drugs on the basis of blood sugar control, which can reduce the patient’s urine protein and blood pressure to a certain extent, but it cannot improve the patient’s symptomatic and expensive

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1, tablet

[0025] ⑴ Crushing process

[0026] Weigh 2g of astragalus, 2g of dried lily, 1g of rhubarb, 1g of peach kernel, and 6g of leech, mix them, grind them into fine powder and pass through a 60-mesh sieve.

[0027] ⑵ Extraction and drying process

[0028] ①Take 2g of Achyranthes bidentata, 6g of Alisma, 6g of Gorgon, 6g of Eucommia, and 2g of Rosa laevigata, mix them with 330mL of water, decoct twice for 2 hours each time, combine the extracts, filter, and concentrate the filtrate to a relative density of 1.25~ 1.30 (50℃) clear ointment, set aside;

[0029] ②The clear paste is microwave-dried, crushed into fine powder, then add the mixed fine powder of astragalus, rhubarb, pagoda japonica, and leech above ⑴, sieve and mix well, and set aside;

[0030] (3) Forming process

[0031] Add 0.6g of 1-3% magnesium stearate to the clear ointment and medicinal powder, make granules, dry, and press into tablets to obtain tablets.

Embodiment 2

[0032] Example 2 Concentrated pills

[0033] ⑴ Crushing process

[0034] Weigh 10 g of astragalus, 10 g of dried lily, 4 g of rhubarb, 6 g of peach kernel, and 1 g of leech, mix them, grind them into fine powder and pass through a 60-mesh sieve.

[0035] ⑵ Extraction and drying process

[0036] ①Take 6g of Achyranthes bidentata, 2g of Alisma, 2g of Gorgon, 2g of Eucommia, 6g of Rosa chinensis, mix with 180mL of water, decoct 3 times, 1 hour each time, combine the extracts, filter, and concentrate the filtrate to a relative density of 1.25~ 1.30 (50℃) clear ointment, set aside;

[0037] ②Microwave-dry the clear cream, crush it into fine powder, then add the mixed fine powder of astragalus, dried lily, rhubarb, peach kernel, and leech above ⑴, sieve and mix well, and set aside;

[0038] (3) Forming process

[0039] Astragalus, dried lily, rhubarb, peach kernel, and leech medicinal powder are mixed with extracts of Achyranthes bidentata, Alisma, Gorgon, Eucommia, and Rosa l...

Embodiment 3

[0040] Embodiment 3, granules

[0041] ⑴ Crushing process

[0042] Weigh 2g of astragalus, 2g of dried lily, 1g of rhubarb, 1g of peach kernel, and 6g of leech, mix them, grind them into fine powder and pass through a 60-mesh sieve.

[0043] ⑵ Extraction and drying process

[0044] ①Take 2g of Achyranthes bidentata, 6g of Alisma, 6g of Gorgon, 6g of Eucommia, 2g of Rosa chinensis, mix with 220mL of water, decoct twice for 2 hours each time, combine the extracts, filter, and concentrate the filtrate to a relative density of 1.25~ 1.30 (50℃) clear ointment, set aside;

[0045] ② Microwave dry the paste, crush it into fine powder, then add the above-mentioned astragalus, dried lily, rhubarb, peach kernel, and leech fine powder, sieve and mix, and set aside;

[0046] (3) Forming process

[0047] Add 30-50g of starch or dextrin to the mixed medicinal powder, mix well, granulate with a certain amount of 95% ethanol, dry, sieve, and make granules to obtain granules.

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Abstract

The invention discloses a Chinese medicinal composition for treating diabetic nephropathy, which relates to the technical field of medicaments for treating diabetes. The Chinese medicinal composition is prepared from the following raw materials in parts by weight: 2-10 parts of astragalus, 2-10 parts of dried lily bulb, 1-6 parts of peach kernel, 1-6 parts of leech, 1-4 parts of rhubarb, 2-6 parts of oriental waterplantain rhizome, 2-6 parts of cherokee rose fruit, 2-6 parts of gorgon euryale seed, 2-6 parts of twotooth achyranthes root and 2-6 parts of cortex eucommiae. The Chinese medicinal composition has the effects of supplementing qi, nourishing yin, clearing heat, expelling dampness, promoting blood circulation and removing obstruction in channels, is suitable for early metaphase diabetic nephropathy, and is mainly specific to the symptoms of deficiency of both vital energy and yin, shortness of breath and strength and polydipsia caused by dampness and heat stasis, stickiness in mouth, urea with foam, edema and the like. Raw materials are combined in a compatible way, replenishment and diminishment are combined, pathogens are attacked without hurting orthodoxy, deficiency is replenished without gathering evils, and the effects of supplementing qi, nourishing yin, clearing heat, expelling dampness, promoting blood circulation and removing obstruction in channels are achieved.

Description

technical field [0001] The invention relates to the technical field of medicines for treating diabetes, in particular to a traditional Chinese medicine composition for treating diabetic nephropathy. Background technique [0002] At present, drugs for the treatment of diabetes are divided into three categories: 1. Pure western medicines, which are represented by insulin, sulfonylureas, glinides, biguanides, thiazolidinones, and α-glucosidase inhibitors. Sugar is quick and effective, but the side effects are obvious. Not only does it have the risk of hypoglycemia, but most oral drugs are not suitable for patients with liver and kidney insufficiency, and can cause secondary failure of the patient's drugs; 2. Combination of Chinese and Western medicines, such drugs Because there are western medicine ingredients, there are side effects on liver and kidney function, and long-term use is harmful to the body; 3. Pure Chinese medicine, with pure Chinese medicine, has relatively litt...

Claims

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Application Information

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IPC IPC(8): A61K36/8967A61P3/10A61P13/12
Inventor 张定华
Owner 张定华
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