Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Arbidol sustained or controlled release capsule and preparation method thereof

A technology of capsules and sustained-release pellets, which is applied in the field of medicine, can solve the problems of taking medicine frequently (taking 3 to 4 times a day, not releasing the active ingredients of the drug quickly, and slow-release tablets, etc.), so as to reduce the number of medications , small weight difference, small local irritation effect

Active Publication Date: 2012-11-14
HUBEI BIO PHARMA IND TECHCAL INST
View PDF10 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the weak point of these preparation technologies is that this medicine is taken in a large dosage, and the number of times of taking medicine is many (take 3~4 times every day). The preparation technology of the effect of the drug will undoubtedly be more attractive
[0013] However, the drug release of simple sustained-release tablets is slow, and the active ingredients of the drug cannot be released quickly, so that the maximum blood drug concentration is low.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Arbidol sustained or controlled release capsule and preparation method thereof
  • Arbidol sustained or controlled release capsule and preparation method thereof
  • Arbidol sustained or controlled release capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Prescription composition

[0044]

[0045] Second, the preparation process:

[0046] (1) Arbidol hydrochloride is pulverized to 100 orders;

[0047] (2) Take arbidol, microcrystalline cellulose, and HPMC K4M in the prescription amount of the sustained-release pellets, mix them evenly, add 3% PVPK30 aqueous solution as a wetting agent to make a soft material, and put it into the extruding pellet machine Prepare pellets by extrusion at 50 rpm and spheronization at 500 rpm, and dry at 80°C for 2 hours to obtain Arbidol sustained-release pellets;

[0048] (3) Select the above-mentioned 20 mesh Abidol slow-release pellets and put them into the coating pan, adjust the coating machine speed to 150 rpm, control the hot air temperature to 45°C, and pre-prepare the Abidol slow-release pellets Heat to 45°C, and at a spray pressure of 0.04Mpa, spray the outer immediate-release film coating solution evenly on the Arbidol sustained-release pellets at a flow rate of 6g / min, th...

Embodiment 2

[0053] 1. Prescription composition

[0054]

[0055] Second, the preparation process:

[0056] (1) Arbidol hydrochloride is pulverized to 100 orders;

[0057] (2) Take arbidol, microcrystalline cellulose, and HPMC K4M in the prescription amount of the sustained-release pellets, mix them evenly, add 3% PVPK30 aqueous solution as a wetting agent to make a soft material, and put it into the extruding pellet machine Prepare pellets by extrusion at 70 rpm and spheronization at 650 rpm, and dry at 80°C for 2 hours to obtain Arbidol sustained-release pellets;

[0058] (3) Select the above-mentioned 20 mesh Abidol slow-release pellets and put them into the coating pan, adjust the coating machine speed to 150 rpm, control the hot air temperature to 45°C, and pre-prepare the Abidol slow-release pellets Heat to 45°C, and at a spray pressure of 0.03Mpa, spray the outer immediate-release film coating solution evenly on the Arbidol sustained-release pellets at a flow rate of 8g / min, an...

Embodiment 3

[0063] 1. Prescription composition

[0064]

[0065] Second, the preparation process:

[0066] (1) Arbidol hydrochloride is pulverized to 100 orders;

[0067] (2) Take arbidol, microcrystalline cellulose, and HPMC K4M in the prescription amount of the sustained-release pellets, mix them evenly, add 3% PVPK30 aqueous solution as a wetting agent to make a soft material, and put it into the extruding pellet machine Prepare pellets by extrusion at 70 rpm and spheronization at 700 rpm, and dry at 80°C for 2 hours to obtain Arbidol sustained-release pellets;

[0068] (3) Select the above-mentioned 20 mesh Abidol sustained-release pellets and put them into the coating pan, adjust the rotating speed of the coating machine to 120 rpm, control the hot air temperature to 45°C, and pre-prepare the Abidol sustained-release pellets Heat to 45°C, under the spray pressure of 0.05Mpa, evenly spray the outer layer immediate-release film coating solution on the Arbidol sustained-release pel...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an arbidol sustained or controlled release capsule and a preparation method thereof. The content filled in the sustained or controlled release capsule is arbidol sustained release micro pills with quick release film lagging covers; the arbidol sustained release micro pill consists of the following raw materials in parts by weight: 50 to 400 parts of hydrochloric arbidol, 10 to 500 parts of microcrystalline cellulose, 2 to 100 parts of HPMC K4M and a proper amount of PVP K30 aqueous solution with the concentration of 3 percent; and the quick release film lagging cover consists of the following raw materials in parts by weight: 10 to 100 parts of hydrochloric arbidol, 50 to 100 parts of Eudragit E100, 5 to 50 parts of talcum powder and 500 parts of ethanol with the volumetric concentration of 95 percent. Compared with the prior art, the capsule has a quick response and can sustain a certain blood concentration; the working time of the medicament is prolonged; the medicine taking frequency is obviously reduced; the medicine taking compliance of patients is improved; and the preparation method is simple, easy to control and suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an Abidol sustained and controlled release capsule and a preparation method thereof. Background technique [0002] Arbidol is a highly effective drug for preventing and treating type A and type B influenza and other acute respiratory virus infections. The mechanism of action is different from commonly used clinical antiviral drugs such as ribavirin, amantadine and rimantadine; it induces interferon and enhances immune function to fight against influenza virus; All of them have antagonism effect, and have a wider antiviral spectrum than amantadines, and also have the effect of activating macrophages, and can effectively treat influenza and other acute respiratory virus infections. Recent studies have shown that the drug also has a better inhibitory effect on atypical viruses at a lower safe concentration. Arbidol was developed by the All-Russian Chemical and Pharmaceutical Rese...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/52A61K31/4045A61K47/38A61P31/16
Inventor 王学海李杰李莉娥许勇刘大鹏范昭泽余艳平田华杨仲文
Owner HUBEI BIO PHARMA IND TECHCAL INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com