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Var. denneanum extract and formula particles thereof

A technology of Dendrobium sheathes and formula granules, which is applied in the field of Dendrobium sheathes extracts and its formula granules, can solve problems such as the extraction method of Dendrobium sheaths that has not been found, and achieve the effect of avoiding waste and ensuring consistency

Active Publication Date: 2012-10-24
SICHUAN WANAN DENDROBIUM IND DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no research report on the extraction method of Dendrobium sheathes, and there is no relevant report on the preparation of formula granules from Dendrobium sheathes

Method used

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  • Var. denneanum extract and formula particles thereof
  • Var. denneanum extract and formula particles thereof
  • Var. denneanum extract and formula particles thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1 The preparation method of the dendrobium sheath extract of the present invention

[0034] (1) Take 100g of Dendrobium sheathing, cut into sections, add 1000ml 70% V / V ethanol to reflux extraction twice, each time for 1.5h, filter to obtain ethanol extract and medicinal residue respectively; Concentrate under reduced pressure, and the concentrate is ready for use;

[0035] (2) Take the medicinal residue obtained in step (1), add 800ml of water, decoct 3 times, each time for 1 hour, and obtain the water extract;

[0036] (3) Take the concentrated solution obtained in step (1), combine it with the water extract obtained in step (2), concentrate it under reduced pressure at 70°C, and then dry it under normal pressure at 70°C, and the obtained dry extract is Dendrobium sheathing Extract, about 10g.

Embodiment 2

[0037] Embodiment 2 The preparation method of the dendrobium sheath dendrobium formula granule of the present invention

[0038] Take 10 g of the Dendrobium sheath extract prepared in Example 1, mix it with 8 g of soluble starch, and use 5 ml of 90% v / v ethanol as a binder to granulate to obtain about 18 g of granules.

Embodiment 3

[0039] Example 3 Detection of the content of Dendrobium sheath dendrobium formula granules of the present invention

[0040] The Dendrobium dendrobii formula granules prepared in Example 2 were assayed, and the method and results were as follows:

[0041] 【Content Determination】Determination according to high performance liquid chromatography (Appendix VI D).

[0042] Chromatographic conditions and system suitability test Octadecylsilane bonded silica gel was used as filler; acetonitrile-0.5% glacial acetic acid (70:30) was used as mobile phase; detection wavelength was 254nm; flow rate was 1ml min -1 ; The column temperature is 25°C; the injection volume is 10 μl;

[0043] Preparation of Reference Substance Solution Take an appropriate amount of Dendrobium phenol reference substance, weigh it accurately, add methanol to make a solution containing 0.5mg per 1ml, and get it.

[0044] Preparation of the test solution Take 1g of this product, weigh it accurately, add 20ml of me...

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Abstract

The invention provides a var. Denneanum extract and a preparation method thereof, wherein the preparation method comprises firstly extracting by using an alcohol-water dual extraction method, and then condensing and drying to obtain the var. Denneanum extract. The invention further provides formula particles of the var. Denneanum and preparation method thereof. According to the preparation method of the var. Denneanum extract provided by the invention, various effective components of the var. Denneanum can be relatively fully extracted by organically combining condition parameters of extraction technology, transfer rate of the dendrobium phenol can reach to more than 80 %, thereby not only ensuring consistency of the var. Denneanum extract and pharmacodynamic material base of original medicinal materials, thus being beneficial to the preparation of formula particles in a later stage, but also effectively preventing wastes of medicinal material resources.

Description

technical field [0001] The invention relates to a dendrobium sheath extract and its formula granules. Background technique [0002] Dendrobium is a well-known yin-tonifying traditional Chinese medicine, which has the functions of nourishing yin and clearing heat, promoting body fluid and benefiting stomach, moistening lung and relieving cough, benefiting kidney and improving eyesight. Modern studies have shown that it has the functions of anti-tumor, enhancing the body's immunity, anti-platelet aggregation, improving vision, dilating blood vessels, and anti-oxidation. The genus Dendrobium is one of the largest genus of Orchidaceae. There are more than 1,500 species in the world, and they are widely distributed in tropical and subtropical regions such as Asia, Europe and Oceania. There are about 76 species in my country, mainly distributed in Southwest, East and South China. Due to the many species of Dendrobium, there are currently more than 30 species of Dendrobium that c...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61K9/16A61P39/06A61P37/04A61P35/00A61P27/10A61P9/08A61P7/02
Inventor 张廷模郭力韩瑜
Owner SICHUAN WANAN DENDROBIUM IND DEV
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