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Acylated chitosan wound dressing, and preparation method and application thereof

A technology of acylated chitosan and wound dressings, which can be used in pharmaceutical formulations, medical science, absorbent pads, etc., and can solve problems such as rupture nursing work, inconvenience, and low wet strength

Active Publication Date: 2012-10-17
FOSHAN UNITED MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, general high moisture absorption dressings such as carboxymethyl solvent-spun cellulose fiber dressings have low wet strength and will break when the dressing is removed, which will cause inconvenience to nursing work

Method used

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  • Acylated chitosan wound dressing, and preparation method and application thereof
  • Acylated chitosan wound dressing, and preparation method and application thereof
  • Acylated chitosan wound dressing, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Preparation of highly hygroscopic acylated chitosan fiber wound dressing:

[0061] 1. Preparation of succinic anhydride-ethanol solution with a concentration of 0.1g / ml: Weigh 894g of succinic anhydride, dissolve it in 8940ml of absolute ethanol, and stir until the succinic anhydride is completely dissolved.

[0062] 2. According to the molar ratio of acid anhydride and chitosan amino group as 4:1, weigh 400 g of chitosan fibers with a degree of deacetylation of 90%, fiber fineness of 1.7 dtex, soak with absolute ethanol for 30 minutes, and then dehydrate.

[0063] 3. Put the chitosan fiber in the succinic anhydride-ethanol solution, and heat it in a water bath at 70°C for 40min.

[0064] 4. After stopping the reaction, take out the fiber, dehydrate, and then wash the remaining reaction solution on the fiber with absolute ethanol.

[0065] 5. Soak the rinsed fibers in an ethanol solution containing Tween-20 for 30 minutes, dehydrate and dry to obtain acylated chitosan ...

Embodiment 2

[0069] Hygroscopicity test of highly hygroscopic acylated chitosan fibrous wound dressing (using BS EN13726-12002 method):

[0070] 1. Take by weighing 5 * 5 cm acylated chitosan non-woven fabrics in Example 1, and weigh W1 to be 0.3557 g.

[0071] 2. Put the non-woven fabric into the petri dish, add the test solution (A solution), the amount of the added solution is 40 times the mass of the sample.

[0072] 3. Put the petri dish into a thermostat at 37°C for 30 minutes.

[0073] 4. Pick up the sample with tweezers, hang it for 30s, and weigh the mass W2 at this time to be 6.6330g.

[0074] 5. Calculate the absorption A according to the following formula: A=(W2-W1) / W1=17.65g / g.

Embodiment 3

[0076] Wet strength test of highly hygroscopic acylated chitosan fibrous wound dressings:

[0077] The dressing in embodiment 1 is cut into 10 * 10cm, cut out the strip of 2 * 10cm from the dressing of 10 * 10cm again, then cut the strip of 2 * 8cm again in this strip 90 degree direction, represent respectively The strength pattern of the fabric in the transverse and longitudinal directions. Soak the middle part of the strip in A solution for 30s, take it out, blot the excess liquid, and test the maximum tensile force when the dressing is stretched and broken. The transverse wet strength of the dressing is 1.52N / cm, the longitudinal direction: 1.04N / cm, and the calculated transverse and longitudinal average wet strength of the dressing is 1.28N / cm.

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Abstract

The present invention relates to an acylated chitosan wound dressing, and a preparation method and application thereof. The wound dressing has high moisture absorption and high wet strength, forms into transparent gel after water absorption and swelling, does not adhere to a wound during contact with the wound, and can be conveniently and integrally removed. The wound dressing of the invention is prepared from acylated chitosan fibers containing carboxyl; and the acylated chitosan fiber is an acylated modified chitosan with an acylation degree of substitution of 0.10-0.50 in chitosan structure unit. As the wound treatment dressing, the acylated chitosan has effects of hemostasis and antibiosis and is especially suitable for the treatment of chronic wounds; and the high moisture absorption provides a moist environment for wound healing, and the wound dressing can rapidly absorb exudate and blood on wound surface to promote wound healing.

Description

technical field [0001] The invention relates to a highly hygroscopic acylated modified chitosan wound dressing, a preparation method and application thereof. Background technique [0002] Chitin widely exists in lower animals, especially in the shells of arthropods, and in the cell walls of lower animals. It is a natural high-molecular organic substance and is rich in natural resources. In addition, chitin is also the nitrogen-containing natural organic compound with the largest amount except protein on the earth. [0003] Chitosan, also known as chitosan, is a product of chitin deacetylated by hydrolysis of concentrated alkali. The chemical name is (1-4)-2-amino-2-deoxy-β-D-glucose, or polyamine for short. base glucose. Chitosan is a natural active polysaccharide that exists widely in nature and is second only to cellulose. Chitosan is non-toxic, non-irritating, non-immunogenic, degradable and good biocompatibility, hemostasis, antibacterial, promotion of wound healing, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28C08B37/08
CPCA61L2300/404A61L15/46A61L15/28A61L2400/04A61L15/60C08L5/08B65B55/02
Inventor 莫小慧王晓东吴振军
Owner FOSHAN UNITED MEDICAL TECH
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