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Clathrate of mesoporous silicon oxide/Fe3O4 magnetic nano-grade complex and ibuprofen

A technology of mesoporous silica and magnetic nanometers, which can be used in drug combinations, organic active ingredients, non-central analgesics, etc., can solve the problem of decreased sensitivity of pain receptors, achieve high drug content, high solubility, increase Conspicuous effect

Inactive Publication Date: 2012-10-17
陈士忠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The analgesic and anti-inflammatory mechanism of ibuprofen has not been fully elucidated. It may act on local inflammatory tissues by inhibiting the synthesis of prostaglandins or other transmitters. Due to the inhibition of leukocyte activity and release of lysosomal enzymes, local tissue Reduced pain impulses, decreased sensitivity of pain receptors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Fe 3 o 4 preparation of

[0015] 2.7gFeCl 3 Dissolve 7.2g of sodium acetate in 100ml of ethylene glycol solution, mix evenly, transfer to a crystallization kettle after stirring evenly, crystallize at 200°C for 6h, wash with absolute ethanol for 3 times, separate, dry at 60°C for 6h, and set aside for use.

Embodiment 2

[0017] Mesoporous silica coated Fe 3 o 4

[0018] 1.0g Fe 3 o 4 Uniformly disperse in the mixture of water and ethanol (80:60 by volume), add 3g of cetyltrimethylammonium bromide templating agent, 10ml of ammonia water (28wt%), stir and mix well, then add 4g of Tetraethyl silicate was stirred for 8 hours, washed 3 times with absolute ethanol, separated, and dried at 60°C.

Embodiment 3

[0020] Mesoporous silica / Fe 3 o 4 Inclusion Compound of Magnetic Nanocomposite and Ibuprofen

[0021] Mesoporous silica / Fe 3 o 4 Add 30 mg of magnetic nanocomposite to ibuprofen ethanol solution (containing 15 mg ibuprofen), ultrasonically react for 5 hours, wash the product with double distilled water, separate with a permanent magnet, and dry at 50°C for 8 hours to obtain mesoporous silica / Fe 3 o 4 Inclusion complexes of magnetic nanocomposites with ibuprofen. The inclusion rate measured by ultraviolet-visible spectrophotometer was 51.10%, and the actual drug content of the inclusion compound was 7.39mg / g.

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PUM

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Abstract

The invention discloses a clathrate of a mesoporous silicon oxide / Fe3O4 magnetic nano-grade complex and ibuprofen. The clathrate is prepared through the steps that: the mesoporous silicon oxide / Fe3O4 magnetic nano-grade complex is added into an ibuprofen ethanol solution, wherein the mass ratio of ibuprofen to the mesoporous silicon oxide / Fe3O4 magnetic nano-grade complex is 1:0.25-25; the mixture is subjected to ultrasonic treatment for 2-5h; an obtained product is washed by using twice-distilled water; the product is separated by using a permanent magnet; the obtained product is subjected to vacuum drying for 6-8h under a temperature of 50-70 DEG C, such that a solid clathrate is obtained. The clathrate can be used for preparing an ibuprofen targeting medicine. Under the effect of an external magnetic field, the contained medicine can be released at the exact position of a lesion site. Therefore, medicine adverse reactions can be reduced, administration frequencies can be reduced, and medicine maximal curative effect can be developed.

Description

technical field [0001] The invention relates to an inclusion compound of ibuprofen, in particular to a mesoporous silicon oxide / Fe 3 o 4 Inclusion complexes of magnetic nanocomposites with ibuprofen. Background technique [0002] Ibuprofen has anti-inflammatory, analgesic and antipyretic effects. It is slightly less effective than acetylsalicylic acid and phenylbutazone in the treatment of rheumatism and rheumatoid arthritis. It is suitable for the treatment of rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and neuritis, etc. The analgesic and anti-inflammatory mechanism of ibuprofen has not been fully elucidated. It may act on local inflammatory tissues by inhibiting the synthesis of prostaglandins or other transmitters. Due to the inhibition of leukocyte activity and release of lysosomal enzymes, local tissue Reduced pain impulses and decreased sensitivity of pain receptors. The treatment of gout is through anti-inflammatory, analge...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/192A61K47/04A61K47/02A61P29/00
Inventor 陈士忠
Owner 陈士忠
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