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Biological material for repairing meniscus tear and preparation method for biological material

A biomaterial and meniscus technology, applied in the field of biomaterials and its preparation for meniscus tear repair, can solve the problems of no biological activity and unfavorable meniscus tissue reconstruction, so as to facilitate clinical operation, promote proliferation rate and its Matrix secretion ability, effect of promoting immigration fusion

Active Publication Date: 2012-10-10
西安博鸿生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Invention patent 200580013082.2 discloses a stent for the repair and regeneration of the avascular meniscus. This invention only provides a passage for blood and its components, cells, and drugs from the vascular area of ​​the tissue to the bloodless area. It does not itself No biological activity, the material itself is in the process of tear repair, and also increases the composition of the meniscus itself; in addition, the degradation of the scaffold material will produce a microenvironment different from that of the body, which is not conducive to the reconstruction of the meniscus tissue

Method used

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  • Biological material for repairing meniscus tear and preparation method for biological material
  • Biological material for repairing meniscus tear and preparation method for biological material
  • Biological material for repairing meniscus tear and preparation method for biological material

Examples

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Effect test

example 1

[0037] Example 1, a kind of biomaterial for repairing rabbit meniscus tear and its preparation method

[0038] The biological material of the torn meniscus in this embodiment is composed of an inner layer of acellular matrix membrane, a middle layer of a porous collagen matrix membrane, and an outer layer of chondrocyte-formed cell layer and cell membrane. The middle layer and the inner layer are compounded by injection molding, casting or scraper, and the middle layer and the outer layer are compounded by chondrocyte seeding collagen matrix membrane.

[0039] The preparation method of the biological material for repairing the torn meniscus of rabbits is carried out according to the following steps:

[0040] Step 1. Preparation of acellular matrix membrane: For the preparation method of acellular human amniotic membrane matrix, please refer to the literature: Song Yongzhou, Cui Huixian, Wang Zhenxian, etc. Preparation and biocompatibility of amniotic membrane acellular matrix ...

example 2

[0051] Example 2, a kind of biomaterial for repairing rabbit meniscus tear and preparation method thereof

[0052] The biological material of this embodiment is sequentially composed of an inner layer of acellular matrix membrane, a middle layer of a porous collagen matrix membrane, and an outer layer of a cell layer formed by chondrocytes and a cell membrane sheet. The middle layer and the inner layer are compounded by injection molding, casting or scraper, and the middle layer and the outer layer are compounded by chondrocyte seeding collagen matrix membrane.

[0053] The preparation method of the biological material for repairing meniscus tear is completed according to the following steps:

[0054] Step 1. Preparation of acellular matrix membrane: the acellular matrix membrane is selected from the submucosa of the small intestine of porcine, and its preparation method refers to the above-mentioned Example 1.

[0055] Step 2: Preparation of a collagen matrix membrane with a...

example 3

[0064] Example 3. A biomaterial for repairing a torn meniscus in rabbits and its preparation method

[0065] The biological material of this embodiment is sequentially composed of an inner layer of acellular matrix membrane, a middle layer of a porous collagen matrix membrane, and an outer layer of a cell layer formed by chondrocytes and a cell membrane sheet. The middle layer and the inner layer are compounded by injection molding, casting or scraper, and the middle layer and the outer layer are compounded by chondrocyte seeding collagen matrix membrane.

[0066] The preparation method of the biological material for repairing meniscus tear is completed according to the following steps:

[0067] Step 1, preparation of acellular matrix membrane: the acellular matrix membrane is selected from human-derived acellular amnion; the preparation method is the same as in Example 1;

[0068] Step 2: Preparation of a collagen matrix membrane with a porous structure: configure a collagen...

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Abstract

The invention relates to a biological material for repairing meniscus tear and a preparation method for the biological material. The material consists of an acellular matrix membrane on the inner layer, a porous structure collagen matrix membrane on the middle layer, a cell layer formed by cartilage cells on the outer layer and a cell sheet. The repair material has certain elasticity and toughness and is high in biological activity; the cartilage cells can secrete cell factors per se, and nutritional ingredients can be directly obtained through articular cavity synovia, and thus, the establishment of communication link between tissue cells at both ends of the tear during the meniscus tear process is accelerated; the immigration and the infusion of the cells in the material and autologous tissue cells are promoted; the tissue regeneration and functional reconstruction time is shortened; and the ideal novel material and the preparation method for the material are provided for clinically repairing the damage of the meniscus tear (including blood supply zones), especially the tissue regeneration and the functional reconstruction of no-blood zones and low-blood zones.

Description

technical field [0001] The invention belongs to the biological material technology of tissue engineering, and relates to a biological material for repairing meniscus tear and a preparation method thereof. Background technique [0002] The meniscus is located between the femoral condyle of the knee joint and the tibial plateau. Its function is to stabilize the knee joint, transmit the load force of the knee joint, absorb vibration, reduce stress, improve joint lubrication, and contribute to the nutrition of articular cartilage. It is precisely because the meniscus plays a role in stabilizing the load, which ensures that the knee joint can carry weight for many years without injury. However, due to knee half-flexion, gravity extrusion, rotation and shear force, etc., meniscus injuries are often caused, and the incidence rate accounts for about 75% of all knee disorders. Meniscus injury often causes quadriceps atrophy, joint pain, elasticity, locking, and limited mobility, lea...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/38A61L27/36A61L27/24
Inventor 田智泉
Owner 西安博鸿生物技术有限公司
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