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Medical device for placement into a lumen and manufacturing method thereof

A technology for medical equipment and manufacturing methods, applied in pharmaceutical formulations, catheters, pharmaceutical sciences, etc., can solve problems such as inability to obtain sufficient drug effects, solvent limitation, and lack of versatility in coating technology, and achieve improved efficiency and improved intake. , the effect of increased cell adhesion

Inactive Publication Date: 2012-10-03
OTSUKA MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, in the methods of Patent Documents 3 to 5, since the elution of the drug component is accompanied by the decomposition of the biocompatible polymer layer, it takes more time than necessary for the elution of any drug, and there is a problem that a sufficient amount of the drug cannot be obtained. problem of effect
In addition, when preparing a coating liquid in which a drug component and a biocompatible polymer are dissolved by these methods, it is necessary to use a solvent capable of dissolving both the biocompatible polymer and the drug, but depending on the biocompatible polymer and the There is a problem of lack of versatility as a coating technique due to the limitation of usable solvents in the combination of drugs

Method used

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  • Medical device for placement into a lumen and manufacturing method thereof
  • Medical device for placement into a lumen and manufacturing method thereof
  • Medical device for placement into a lumen and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0175] Example 1 (Preparation 1 of Drug Particle Suspension)

[0176] A solution was prepared by dissolving 1 g of probucol in a mixed solution of 40 mL of acetone and 20 mL of ethanol as a good solvent. In addition, 15 g of an aqueous solution of 2% by weight of chitosan (CHITOSAN GH-400EF, manufactured by NOF) was mixed with 100 mL of an aqueous solution of 2% by weight of polyvinyl alcohol (Gosenol EG05, manufactured by Nippon Synthetic Chemical Industry Co., Ltd.) to prepare a solution relative to probucol solutions in poor solvents. In this solution, under stirring at 40°C and 400rpm, the previous probucol solution was added dropwise at a certain speed (20mL / min), and the crystalline drug particles (probucol) were obtained through the diffusion of the so-called good solvent into the poor solvent. test) suspension.

[0177] Next, acetone and ethanol were distilled off under reduced pressure. The zeta potential on the particle surface was measured by electrophoresis (M...

Embodiment 2

[0183] Example 2 (Preparation 2 of Drug Particle Suspension)

[0184] The drug particles were prepared under the same conditions as in the manufacturing method of Example 1 except that the drug particles were not pulverized by a desktop ball mill, and the average particle diameter of the drug particles was 21.5 μm.

Embodiment 3

[0185] Example 3 (Preparation 3 of Drug Particle Suspension)

[0186] Drug particles were prepared under the same conditions as in the production method of Example 1 except that 60 g of the 2% by weight chitosan aqueous solution added to the solution corresponding to the poor solvent was used. The average particle diameter of the drug particles by the laser diffraction scattering method was 4.5 μm. The ξ potential was +45mV, the content rate of probucol in the drug particles was 53%, and the pass rate was 65%.

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Abstract

Provided is a medical device for placement into a lumen and a simple and inexpensive manufacturing method thereof, said medical device being a stent or a catheter and the surface thereof being uniformly and sufficiently coated with a drug. Drug particles having positive-charge modified surfaces and biocompatible nanoparticles are mixed and stuck to the medical device. After the DES is placed inside a living organism, the drug particles are eluted together with the biocompatible nanoparticles and efficiently taken into cells.

Description

technical field [0001] The present invention relates to a drug-eluting medical device for indwelling in a lumen, which is a stenosis formed in a lumen in a living body, and a manufacturing method thereof. Or medical devices for indwelling in the lumen such as stents or catheters to maintain the open state of the blocked part. Background technique [0002] With the advancement of medical treatment in recent years, the treatment and prevention of various diseases represented by infectious diseases have made remarkable progress. However, the number of patients with arteriosclerosis caused by lifestyle habits is still increasing. tendency. In particular, arteriosclerotic diseases such as myocardial infarction, angina pectoris, stroke, and peripheral vascular disease are increasing in Japan along with Westernization of lifestyle and aging. As a reliable treatment method for such arteriosclerotic diseases, for example, percutaneous intravascular coronary angioplasty, which surgi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/82A61L29/00A61L31/00
CPCA61L2300/624A61L29/08A61F2/82A61L29/16A61L29/085A61L29/06A61L31/08A61F2250/0067A61L31/16A61L29/043A61L31/042A61L2300/416A61L2400/12A61L31/10A61L2400/18A61L2300/42A61L31/06A61L2300/606A61L31/022A61P7/02A61P9/08C08L5/08C08L67/04C08L5/04A61L29/00A61L31/00
Inventor 江头健辅辻本广行原香织塚田雄亮板东容平真锅松也
Owner OTSUKA MEDICAL DEVICES
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