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Water-phase preparation method of near-infrared luminescent silver sulfide quantum dot

A water-phase preparation, quantum dot technology, applied in chemical instruments and methods, luminescent materials, silver compounds, etc., can solve the problems of quantum dot size increase, luminescence intensity weakening, biological tissue damage, etc., to achieve good dispersibility, good Biocompatibility, mild reaction conditions effect

Inactive Publication Date: 2012-10-03
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003]Currently, synthesized quantum dots that emit light in the near-infrared region Mainly compounds containing Pb, Cd, Hg such as PbS, PbSe, CdHgTe, etc. These compounds will release heavy metal ions in the form of ions after entering biological tissues, causing damage to biological tissues
On the other hand, most of the current synthesis methods of quantum dots are synthesized in the organic phase, and when they act on organisms, they need to be transferred to the aqueous phase through ligand exchange. However, in the process of ligand exchange, the size of quantum dots increases. Large, and the luminous intensity is weakened or even quenched

Method used

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  • Water-phase preparation method of near-infrared luminescent silver sulfide quantum dot
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  • Water-phase preparation method of near-infrared luminescent silver sulfide quantum dot

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Effect test

Embodiment 1

[0034] 1. Prepare 50ml of 0.5% bovine serum albumin solution with double distilled water; add silver nitrate (1mmol / L, 25ml) dropwise to the bovine serum albumin solution with a stirring speed of 30 rpm, 25 ℃ overnight in the dark to obtain reaction solution 1; sodium sulfide (3mmol / L, 25ml) was placed in the syringe on the syringe pump, and added dropwise at a speed of 480 μL / min to the reaction solution with a stirring speed of 50 rpm 1. After the dropwise addition, the reaction continued for 10 minutes. After the reaction was completed, the reaction solution 2 was obtained; put 50 mL of the reaction solution 2 into a semi-permeable membrane dialysis bag soaked in ultrapure water (MWCO (molecular weight cut-off) = 100KDs), two After the end is sealed, dialyze in 1 L of distilled water to remove ions that have not participated in the reaction; the distilled water is replaced every 6 hours, and dialyzed for 2 days to obtain the product solution; the above operations are all...

Embodiment 2

[0039] 1. Use double-distilled water to prepare 50ml of bovine serum albumin solution with a concentration of 1% by mass; add silver nitrate (1mmol / L, 25ml) dropwise to the bovine serum albumin solution with a stirring speed of 30 rpm, React overnight at 25°C in the dark to obtain reaction solution 1; thioacetamide (0.3mmol / L, 25ml) was placed in the syringe on the syringe pump, and added dropwise at a speed of 100 μL / min until the stirring speed was 50 rpm Minutes of reaction solution 1, after the dropwise addition, the reaction continued for 10 minutes, and the reaction was completed to obtain reaction solution 2; 50 mL of reaction solution 2 was placed in a semi-permeable membrane dialysis bag soaked in ultrapure water (MWCO (molecular weight cut-off) = 100KDs), sealed at both ends, dialyzed in 1 L of distilled water to remove unreacted ions; the distilled water was changed every 6 hours, and dialyzed for 2 days to obtain the product solution; the above operations were a...

Embodiment 3

[0043]1. Use double-distilled water to prepare 50ml of bovine serum albumin solution with a mass ratio concentration of 2%; silver nitrate (1mmol / L, 25ml) is added dropwise to the bovine serum albumin solution at a stirring speed of 30 rpm, 30 ℃ overnight in the dark to obtain reaction solution 1; sodium sulfide (3mmol / L, 25ml) was placed in the syringe on the syringe pump, and added dropwise at a speed of 100 μL / min to the reaction solution with a stirring speed of 50 rpm 1. After the dropwise addition, the temperature of the reaction was raised to 70°C and kept for 2 hours. After the reaction was completed, the reaction solution 2 was obtained; after the reaction solution was cooled to room temperature, 50 mL of the reaction solution 2 was placed in a semi-permeable membrane soaked in ultrapure water In a dialysis bag (MWCO (molecular weight cut-off) = 100KDs), after both ends are sealed, dialyze in 1 L of distilled water to remove ions that have not participated in the react...

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Abstract

The invention belongs to the technical field of functional nanometer materials, in particular to a water-phase preparation method of a near-infrared luminescent silver sulfide quantum dot. The preparation method is a normal-temperature and normal-pressure water-phase preparation method and comprises the following steps of: with silver nitrate, bovine serum albumin and sodium sulfide as raw materials, regulating and controlling the nucleation and growth of a nanometer material by using protein, and eliminating unreacted ions through dialysis via a semipermeable membrane to obtain an extra-small (smaller than 10 nanometers) silver sulfide quantum dot stably existing in a water solution. In the preparation process, water is used as a solvent, conditions are mild, operability is strong, an extra-small quantum dot with good luminescent window and better biocompatibility is obtained under extremely mild reaction conditions, and the quantum dot is hopeful to achieve broad application prospect in the aspect of living organism imaging.

Description

technical field [0001] The invention belongs to the technical field of functional nanometer materials, and in particular relates to a water-phase preparation method of near-infrared luminescent silver sulfide quantum dots. Background technique [0002] Near-infrared quantum dots, especially near-infrared The region window (1.0~1.4 μm) is ideal for in vivo imaging. On the one hand, in this wavelength range, the tissue self-luminescence signal is low, and the light scattering and absorption of the tissue are also very low, and the optical signal with a large tissue penetration depth can be obtained. The damage is less; on the other hand, near-infrared imaging technology can have higher resolution and sensitivity. Therefore, the synthesis and application of near-infrared luminescent quantum dots have received more and more attention in recent years. [0003] Currently, synthesized near-infrared The quantum dots that emit light in the area are mainly compounds containing P...

Claims

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Application Information

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IPC IPC(8): C01G5/00B82Y30/00C09K11/56
Inventor 杨嬅嬿余绍宁
Owner FUDAN UNIV
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