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MAAPN extractive and composition thereof

A carnosine glycoside and extract technology, applied in the field of medicine, can solve the problems of destroying active ingredients and difficult to significantly increase the content of active ingredients, and achieve the effects of reducing interference, excellent therapeutic effect and high content of active ingredients

Active Publication Date: 2012-10-03
夏智红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this high-temperature extraction will undoubtedly destroy the active ingredients
It is always difficult to significantly increase the content of active ingredients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Carbon dioxide saturation: Take rabbit heart and muscle, remove fat, homogenate separately, then vacuumize to 8Pa respectively, keep the pressure for 25min, then introduce carbon dioxide to the pressure of 18MPa, keep the pressure for 25min, then vacuumize and inflate repeatedly for 2 Second-rate;

[0034] Freezing and thawing: Slowly add the carbon dioxide-saturated rabbit heart and muscle slurry to the liquid carbon dioxide whose volume is 13 times the weight of the rabbit heart and muscle respectively at a rotation speed of 800rpm. The adding time is 35 minutes. After adding, stir for 2 hours and cool down to Keep at 80°C for 8 hours, then raise the temperature to 45°C for 7 minutes to vaporize carbon dioxide;

[0035] Enzyme hydrolysis: Take the frozen-thawed rabbit heart and muscle according to the weight ratio of 1:3, respectively add 2 times the weight of water for injection, and stir evenly to obtain the heart tissue solution and muscle tissue solution respectiv...

Embodiment 2

[0038] Carbon dioxide saturation: take rabbit heart and muscle, remove fat, homogenate separately, then vacuumize to 5Pa respectively, keep the pressure for 25min, then introduce carbon dioxide to the pressure of 16MPa, keep the pressure for 28min, then vacuumize and inflate repeatedly for 2 Second-rate;

[0039] Freezing and thawing: Slowly add the carbon dioxide-saturated rabbit heart and muscle slurry to the liquid carbon dioxide whose volume is 11 times the weight of the rabbit heart and muscle respectively at a rotation speed of 800rpm. The adding time is 35 minutes. After adding, stir for 2 hours and cool down to Keep at 80°C for 7 hours, then raise the temperature to 40°C for 7 minutes to vaporize carbon dioxide;

[0040] Enzyme hydrolysis: Take the frozen-thawed rabbit heart and muscle according to the weight ratio of 1:3, respectively add 2 times the weight of water for injection, and stir evenly to obtain the heart tissue solution and muscle tissue solution respectiv...

Embodiment 3

[0043] Carbon dioxide saturation: Take rabbit heart and muscle, remove fat, homogenate separately, then vacuumize to 8Pa respectively, keep the pressure for 22min, then introduce carbon dioxide to the pressure of 15MPa, keep the pressure for 30min, then vacuumize and inflate repeatedly for 2 Second-rate;

[0044] Freezing and thawing: Slowly add the carbon dioxide-saturated rabbit heart and muscle slurry to the liquid carbon dioxide whose volume is 14 times the weight of the rabbit heart and muscle respectively at a rotation speed of 800rpm. The adding time is 30min. After adding, stir for 2h and cool down to Keep at 80°C for 6 hours, then raise the temperature to 50°C for 10 minutes to vaporize carbon dioxide;

[0045] Enzyme hydrolysis: Take the frozen and thawed rabbit heart and muscle according to the weight ratio of 1:3, respectively add 2 times the weight of water for injection, and stir evenly to obtain the heart tissue solution and muscle tissue solution respectively. ...

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Abstract

The invention relates to an MAAPN (Muscular Amino Acids and Peptides and Nucleosides) extractive containing drug regimen ingredients such as polypeptide, amino acid, nucleoside and nucleotide, as well as the composition thereof. The preparation method comprises the following steps: taking out heart and muscle of a rabbit, removing grease, homogenate, vacuum-pumping, leading in carbon dioxide, then vacuum-pumping, and inflating repeatedly for two times; respectively adding carbon dioxide saturated rabbit heart and muscle slurry into liquid carbon dioxide for stirring, cooling down to 80 DEG C below zero, keeping for 6 to 10 hours, increasing temperature to 40 to 50 DEG C, respectively taking rabbit heart and muscle after freeze thawing according weight ratio of one to three and adding into injection water respectively, adding heart tissue solution into elastic protease, and adding muscular tissue solution into papayotin; combining zymolytic heart tissue solution and muscular tissue solution, carrying out centrifugation, taking supernatant fluid, adding 0.3 times of activated charcoal in weight, stirring for 30 min in the room temperature, and filtering through a micropore filtration film. Excipient can be added into the composition prepared by the extractive so as to make squirt, powder for injection or freeze-dried powder.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a carnosine glycoside extract and a composition thereof. Background technique [0002] Carnosine glycosides is a drug containing a variety of vasoactive substances extracted from mammalian myocardium using modern biotechnology. The main components are atrial peptide, calcitonin gene-related peptide, and adenosine. It contains a large number of polypeptides, amino acids, nucleosides and nucleotides and other components. Atrial peptide has strong natriuretic, diuretic, vascular smooth muscle relaxation and inhibition of renin-angiotensin-aldosterone system. The calcitonin gene-related peptide is the strongest vasodilation active peptide known in the body. It is a biologically active polypeptide composed of 37 amino acids expressed and produced by the calcitonin gene. Coronary blood flow, enhance myocardial contractility, and protect ischemic myocardium. Carnosine glycosides can be used i...

Claims

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Application Information

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IPC IPC(8): A61K35/24A61P9/04A61P9/10A61P9/12
Inventor 夏智红
Owner 夏智红
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