Florfenicol soluble power and preparation method thereof

Abstract

The invention discloses florfenicol soluble power. The florfenicol soluble power consists of by weight, florfenicol 65-75%, polyethylene glycol 6000 10-15%, polyvinyl pyrrolidone (PVP) 5-10% and carbomer 5-10%. By means of reasonable compounding of the florfenicol, the polyethylene glycol 6000, the PVP and the carbomer, the water solubility of the florfenicol is improved greatly, and the long-acting slow release effect is played. Due to the fact that the polyethylene glycol 6000, the PVP and the carbomer belong to high molecular polymers, the solution rate in a body is slow, the bioavailability of the florfenicol in the human body is improved fully, and the treatment effect of the florfenicol in an animal body is improved greatly (shown in figure). The florfenicol which is difficultly soluble in water is manufactured into the florfenicol soluble power capable of being soluble in water in clinical application, and the florfenicol soluble power is convenient and effective in the clinical application.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a florfenicol soluble powder and a preparation method thereof. Background technique Florfenicol (Florfenicol) Chinese name is fluprofen, florfenicol or florfenicol. It is a new broad-spectrum antibacterial drug of chloramphenicol for veterinary medicine successfully developed in the late 1980s. In 1990 It was first listed in Japan in 1993. In 1993, Norway approved the drug to treat salmon furuncle. In 1995, France, Britain, Austria, Mexico and Spain approved florfenicol for the treatment of bovine respiratory bacterial diseases. It was also approved in Japan and Mexico. It is used as a feed additive for pigs to prevent and treat bacterial diseases in pigs. Our country has passed the approval of this drug at present. Florfenicol has high practical value, but there is still a problem that is difficult to solve, that is, Florfenicol is insoluble in water and has low bioavailabi...

AI Technical Summary

Problems solved by technology

Florfenicol has high practical value, but there is still a problem that is difficult to solve, that is, Florfenicol is insoluble in water and has low bioavailability, so it cannot give full play to its efficacy. This problem has not been solved well. the solution

At present, the methods to solve the water solubility of florfenicol in my country are mainly physical methods, such as cosolvent micronization, β-cyclodextrin inclusion complex, hydroxypropyl β-cyclodextrin inclusion complex, PVP K dispersion, PEG 6000 dispersion , ultrafine, grinding and other methods, but the solubilizing effects of these methods are generally not ideal, and there are still problems of slow dissolution rate and low dissolution rate, which are difficult to meet the needs of preparations and concentrated formulations.

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