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Sodium hyaluronate eye drops and a preparation method thereof

A technology of sodium hyaluronate and eye drops, which is applied in the field of medicine, can solve the problems of easy contamination and growth of bacteria, and achieve the effects of stable and feasible preparation process, prolonging tear film breakup time and good stability

Active Publication Date: 2013-08-07
ZHEJIANG JIANFENG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] In order to solve the technical defects of the stability of sodium hyaluronate and the tendency to be contaminated and grow bacteria, an object of the present invention is to provide a sodium hyaluronate eye drop, which has good antibacterial performance and good stability specialty

Method used

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  • Sodium hyaluronate eye drops and a preparation method thereof
  • Sodium hyaluronate eye drops and a preparation method thereof
  • Sodium hyaluronate eye drops and a preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Sodium hyaluronate eye drops, each 100ml consists of the following components:

[0069] Sodium Hyaluronate 100mg, Boric Acid 150mg,

[0070] Borax 12mg, Edetate Disodium 10mg,

[0071] 6-aminocaproic acid 100mg, mannitol 100mg,

[0072] Sodium Chloride 700mg, Benzalkonium Chloride 5mg,

[0073] Borneol 10mg, add water for injection to 100ml.

[0074] The preparation method of above-mentioned sodium hyaluronate eye drops, comprises the following steps:

[0075] 1) Take 50% of the prepared water for injection in advance and cool it to 50~60°C and pour it into the mixing bucket, accurately weigh the sodium hyaluronate, add the sodium hyaluronate while stirring, soak until completely dissolved;

[0076] 2) Take 30% of the prepared water for injection and put it in a stainless steel bucket, accurately weigh boric acid, borax, disodium edetate, 6-aminocaproic acid, mannitol, and sodium chloride, and add them into the stainless steel bucket in sequence , after stirring an...

Embodiment 2

[0084] Sodium hyaluronate eye drops, each 100ml consists of the following components:

[0085] Sodium Hyaluronate 90mg, Boric Acid 110mg,

[0086] Borax 12mg, Edetate Disodium 10mg,

[0087] 6-aminocaproic acid 100mg, mannitol 90mg,

[0088] Sodium Chloride 700mg, Benzalkonium Chloride 5mg,

[0089] Borneol 10mg, add water for injection to 100ml.

[0090] The preparation method is shown in Example 1.

Embodiment 3

[0092] Sodium hyaluronate eye drops, each 100ml consists of the following components:

[0093] Sodium Hyaluronate 140mg, Boric Acid 180mg,

[0094] Borax 18mg, Edetate Disodium 12mg,

[0095] 6-aminocaproic acid 150mg, mannitol 140mg,

[0096] Sodium Chloride 650mg, Benzalkonium Chloride 5mg,

[0097] Borneol 12mg, add water for injection to 100ml.

[0098] The preparation method is shown in Example 1.

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Abstract

The invention relates to the field of medicine, in particular to sodium hyaluronate eye drops and a preparation method thereof. Sodium hyaluronate eye drops, the eye drops are composed of the following components per 100ml: sodium hyaluronate 80~150mg, boric acid 130~200mg, borax 10~20mg, edetate disodium 8~15mg, 6-aminohexyl Acid 80~160mg, mannitol 80~160mg, sodium chloride 600~800mg, benzalkonium chloride 3~10mg, borneol 8~15mg, add water for injection to 100ml, and adjust the pH to 6.0~7.8. The eye drop of the invention has the effect of promoting healing on corneal epithelial damage, can obviously prolong tear film breakup time, and has better effect on improving dry eye disease symptoms. At the same time, the present invention has good stability at room temperature, and the data of each batch are similar, indicating that the preparation process is stable and feasible. Used within the validity period, all indicators of HA-Na are within the quality control range.

Description

technical field [0001] The invention relates to the field of medicine, in particular to sodium hyaluronate eye drops and a preparation method thereof. Background technique [0002] Sodium hyaluronate, also known as sodium hyaluronate (sodium Hyaluronate, HA-Na), is an acidic mucopolysaccharide macromolecule prepared by cockscomb extraction or microbial fermentation, with a molecular weight of about 800,000-2.5 million. It is composed of N-acetylglucosamine and glucose Sodium aldolate is a linear macromolecule formed by the polymerization of disaccharide units. Sodium hyaluronate is a physiologically active substance widely present in the human body. It is distributed in the vitreous body of the eye, aqueous humor, skin, joint synovial fluid, umbilical cord, etc., and plays a role in lubrication, water retention, buffering, viscoelasticity, wound repair, and network fixation. and regulation of cells. [0003] Sodium hyaluronate can be used as a filler in ophthalmic surgery,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/728A61K47/16A61K47/10A61K47/02A61P27/02A61K31/198A61K31/045
Inventor 蒋晓萌黄金龙殷之武施存元张孝君施小扬
Owner ZHEJIANG JIANFENG PHARM CO LTD
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