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Preparation method for organic-inorganic hybrid skin-friendly efficient sunscreen product

A friendly and inorganic technology, applied in skin care preparations, cosmetic preparations, cosmetics, etc., can solve problems such as skin damage, and achieve the effects of adjustable size, good dispersion and good sun protection effect.

Inactive Publication Date: 2012-09-19
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Titanium dioxide absorbs and reflects ultraviolet rays and is accompanied by highly efficient catalytic degradation, which may cause damage to the skin

Method used

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  • Preparation method for organic-inorganic hybrid skin-friendly efficient sunscreen product
  • Preparation method for organic-inorganic hybrid skin-friendly efficient sunscreen product
  • Preparation method for organic-inorganic hybrid skin-friendly efficient sunscreen product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] With polyethylene glycol monomethyl ether (PEO-Br) brominated at one end as the initiator, cuprous bromide (CuBr)

[0030] As a catalyst, PMDETA as a ligand, anhydrous methanol as a solvent, and dimethylaminoethyl methacrylate (DMA) with a molar ratio of 10:1 to the initiator as a monomer, under anhydrous and oxygen-free conditions at 30°C Atom Transfer Radical Polymerization to Obtain Diblock Polymer PEO 43 - b -PDMA 10 After 12 hours of reaction, the monomer styrene (Styrene) with a molar ratio of 80:1 to the macromolecular initiator was added to continue the reaction for 20 hours at a temperature of 110°C to obtain an amphiphilic triblock polymer PEO 43 - b -PDMA 10 - b -PS 80 .

[0031] PEO 43 - b -PDMA 10 - b -PS 80 The triblock polymer was dissolved in THF at a concentration of 50 mg / mL, and absolute ethanol was added dropwise for self-assembly, and the concentration of the polymer nanoparticle solution obtained after stirring for 50 h was 1 mg / mL. ...

Embodiment 2

[0036] PEO-DDMAT with azobisisobutyronitrile (AIBN) as the initiator and a molar ratio of 1:5 to the initiator

[0037] As a chain transfer agent, anhydrous tetrahydrofuran (THF) is used as a solvent, and dimethylaminoethyl methacrylate (DMA) with a molar ratio of 40:1 to the initiator is used as a monomer, at 70°C under anhydrous and oxygen-free conditions After 12 hours of reaction, styrene was dissolved in p-xylene and added to the reaction vessel to continue the reaction for 24 hours to obtain the amphiphilic triblock polymer PEO 43 - b -PDMA 40 - b -PS 30 .

[0038] PEO 43 - b -PDMA 40 - b -PS 30 The triblock polymer was dissolved in dichloromethane at a concentration of 30 mg / mL, absolute ethanol was added dropwise for self-assembly, and the concentration of polymer nanoparticles obtained after stirring for 50 h was 2 mg / mL.

[0039] Dissolve ethyl titanate in absolute ethanol at a concentration of 5 mg / mL, drop it into a solution of polymer nanoparticles...

Embodiment 3

[0041] With polyethylene glycol monomethyl ether (PEO-Br) brominated at one end as the initiator, cuprous bromide (CuBr)

[0042] As a catalyst, PMDETA as a ligand, anhydrous methanol as a solvent, and dimethylaminoethyl methacrylate (DMA) with a molar ratio of 60:1 to the initiator as a monomer, under anhydrous and oxygen-free conditions at 30°C Atom Transfer Radical Polymerization to Obtain Diblock Polymer PEO 43 - b -PDMA 60 , after the reaction was carried out for 8 hours, the monomer styrene with a molar ratio of 120:1 was added to the macroinitiator to continue the reaction for 20 hours, and the temperature was 110 ° C to obtain the amphiphilic triblock polymer PEO 43 - b -PDMA 60 - b -PS 120 .

[0043] PEO 43 - b -PDMA 60 - b -PS 120 The triblock polymer was dissolved in dimethylformamide (DMF) at a concentration of 10 mg / mL, and absolute ethanol was added dropwise for self-assembly, and the concentration of polymer nanoparticles obtained after stirring for...

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Abstract

The invention belongs to the technical field of chemical products of beauty and skincare cosmetics, and particularly relates to a preparation method for an organic-inorganic hybrid skin-friendly efficient sunscreen product. The method comprises the following steps of: performing macromolecular self-assembly on a synthesized amphiphilic triblock polymer PEO-b-PDMA-b-PS to obtain polymer nanoparticles with uniform particle size distribution; and performing in-situ reaction on a deposited titanium precursor on the nanoparticles, drying in-situ reaction products to obtain organic-inorganic hybridtitanium dioxide nanoparticles, and further calcining the organic-inorganic hybrid titanium dioxide nanoparticles to obtain titanium dioxide nanoparticles. The method is characterized in that the skin-friendly titanium dioxide nanoparticles with high sunscreen performance can be prepared, are harmless to skin, have good ultraviolet resistant effects, and have high dispersion performance in water;the particle sizes of the ultraviolet resistant nanoparticles can be randomly controlled; and the preparation method is simple and wider in application range.

Description

technical field [0001] The invention belongs to the technical field of beauty, skin care and cosmetic chemicals, and in particular relates to a preparation method of an organic-inorganic hybrid skin-friendly high-efficiency sunscreen product. Background technique [0002] In recent years, more and more reports about skin cancer have made people more and more aware of the serious harm of ultraviolet rays. And with the over-exploitation of the environment by humans, the ozone layer in the atmosphere is constantly being destroyed, and more and more ultraviolet rays irradiate the surface of the human body, causing damage to the skin, eyes and immune system. Ultraviolet rays in sunlight can be divided into the following three types: long-wave ultraviolet (UVA) with a wavelength of 320-400nm, medium-wave ultraviolet (UVB) with a wavelength of 280-320nm, and short-wave ultraviolet (UVC) with a wavelength of 200-280nm. Among them, UVA can cause pigmentation, resulting in skin tanni...

Claims

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Application Information

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IPC IPC(8): C08F293/00C08F2/38C08F2/44C08K5/56C08K3/16A61K8/29A61Q17/04
Inventor 杜建忠肖杰
Owner TONGJI UNIV
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