Antibacterial nano silver modified polymeric micelle and preparation method thereof

A technology of polymer glue and nano-silver, which is applied in the direction of antibacterial drugs, medical preparations of non-active ingredients, pharmaceutical formulas, etc., can solve the problems of complicated preparation methods, inconvenient use, narrow use range, etc., and achieve simple preparation methods, Wide range of applications and the effect of avoiding the problem of solvent residue

Inactive Publication Date: 2012-09-19
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although the nano-silver prepared above has certain antibacterial and antibacterial effects, its preparation method is relatively complicated, and the prepared nano-silver reagent and coating film components are complex, inconvenient to use, and the application area is also relatively narrow.
[0008] In summary, using amphiphilic block polymers as micellar templates to modify nano-silver in its hydrophobic core can effectively avoid the problem of nano-silver agglomeration, and at the same time have a good antibacterial and bactericidal effect. There is no related research in China. Patented Inventions Emerge

Method used

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  • Antibacterial nano silver modified polymeric micelle and preparation method thereof
  • Antibacterial nano silver modified polymeric micelle and preparation method thereof
  • Antibacterial nano silver modified polymeric micelle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Macromolecular initiator PEO 43 -Synthesis of Br

[0039]Azeotropically distill 10g of flaky PEO and 250mL of toluene to remove excess water, lower the temperature of the system to room temperature, change to an ice-water bath, add 2mL of triethylamine, 1.9mL of 2-bromoisobutyryl bromide in 20mL of toluene , reacted for 40h, filtered, extracted, collected the organic phase, dried, filtered, precipitated, suction filtered, and vacuum-dried to obtain a white powdery macromolecular initiator PEO 43 -Br.

[0040] (2) ATRP synthetic polymer

[0041] 0.5g of macroinitiator PEO 43 -Br, 0.035g of catalyst cuprous bromide (CuBr), 0.040g of ligand PMDETA, 1.16g of monomer dimethylaminoethyl methacrylate (DMA), 3.16g of tert-butyl acrylate ( t BA) and 2mL of methanol solvent were added to a 50mL round-bottomed flask, and atom transfer radical polymerization (ATRP) was carried out under the protection of nitrogen or argon in anhydrous and oxygen-free conditions, at a temper...

Embodiment 2

[0051] (1) Macromolecular initiator PEO 43 -Synthesis of Br

[0052] Azeotropically distill 10g of flake PEO and 250mL of toluene to remove excess water, lower the temperature of the system to room temperature, change to an ice-water bath, add 2mL of triethylamine, 20mL of toluene solution of 1.9mL of 2-bromoisobutyryl bromide, The reaction was carried out for 40h, filtered, extracted, and the organic phase was collected, dried, filtered, precipitated, suction filtered, and vacuum-dried to obtain a white powdery macromolecular initiator PEO 43 -Br.

[0053] (2) ATRP synthetic polymer

[0054] 0.5g of macroinitiator PEO 43 -Br, 0.035g of catalyst cuprous bromide (CuBr), 0.040g of ligand PMDETA, 1.16g of monomer dimethylaminoethyl methacrylate (DMA), 2.06g of tert-butyl acrylate ( t BA) and 2mL of methanol solvent were added to a 50mL round-bottomed flask, and atom transfer radical polymerization (ATRP) was carried out under the protection of nitrogen or argon in anhydrous a...

Embodiment 3

[0060] (1) Macromolecular initiator PEO 45 -Synthesis of Br

[0061] Azeotropically distill 10g of flake PEO and 250mL of toluene to remove excess water, lower the temperature of the system to room temperature, change to an ice-water bath, add 2mL of triethylamine, 1.0mL of 2-bromoisobutyryl bromide in 20mL of toluene, The reaction was carried out for 40h, filtered, extracted, and the organic phase was collected, dried, filtered, precipitated, suction filtered, and vacuum-dried to obtain a white powdery macromolecular initiator PEO 43 -Br.

[0062] (2) ATRP synthetic polymer

[0063] 0.5g of macroinitiator PEO 43 -Br, 0.035g of catalyst cuprous bromide (CuBr), 0.040g of ligand PMDETA, 0.86g of monomer dimethylaminoethyl methacrylate (DMA), 3.56g of tert-butyl acrylate ( t BA) and 2mL of methanol solvent were added to a 50mL round-bottomed flask, and atom transfer radical polymerization (ATRP) was carried out under the protection of nitrogen or argon in anhydrous and oxygen...

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Abstract

The invention belongs to the high-molecular nano biomedical materials, and specifically relates to a polymeric micelle in which the antibacterial nano silver is deposited at the core, and a preparation method of the polymeric micelle. Amphiphilic block copolymers form the micelle in a self-assembly manner through a direct dissolution method, and then, nano silver is generated at the core of the micelle in situ. The micelle has biocompatibility and also has certain temperature and pH sensitivity, the core-shell structure of the micelle can package multiple drugs, and simultaneously, with the existence of nano silver, the micelle has the curative effects of sterilization and bacterial inhibition.

Description

technical field [0001] The invention belongs to the field of macromolecule nano biomedical materials, and in particular relates to an antibacterial nano-silver modified polymer micelle and a preparation method thereof. Background technique [0002] In recent years, the preparation of polymer micelles by self-assembly technology has attracted more and more attention from scientists from all over the world, because the polymer molecules that make up the micelles will change with the external pH, temperature, magnetic field, electric field, light and redox conditions. Corresponding changes in morphology, structure or composition endow polymer micelles with many excellent properties. Based on this, polymer micelles have broad application prospects in many fields, such as drug loading, gene carriers, Biomineralization templates, microreactors, bioscaffolds, etc. [0003] Amphiphilic block polymers can self-assemble in water to form micelles with a core-shell structure. Compared ...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K47/02A61K9/14A61K33/28A61P31/04C08L53/00C08K3/08C08F293/00C08F8/12C08J3/03
Inventor 杜建忠路航
Owner TONGJI UNIV
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