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Medicinal composition for treating gout and preparation method thereof

A technology of composition and medicine, which is applied in the field of pharmaceutical composition and its preparation for the treatment of gouty nephropathy, which can solve the problems of adverse drug reactions, serious patients, inability to effectively reduce blood uric acid, gouty nephropathy traditional Chinese medicine preparations, etc.

Inactive Publication Date: 2014-02-26
周瑾 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, Western medicine at home and abroad often uses uric acid reduction, inhibition of uric acid synthesis and other methods to reduce blood uric acid in the treatment of gouty nephropathy. It is hoped that by reducing blood uric acid to normal, the purpose of preventing kidney damage can be achieved. The excretion of urinary protein has not decreased, and some patients will have more serious adverse drug reactions
In order to avoid recurrent attacks of arthritis and the formation of kidney lesions, gout patients need to take drugs that can lower blood uric acid for a long time, but currently there are few safe, effective, and economical drugs for lowering blood uric acid
my country has a long history of using Chinese herbal medicine to treat gout, but so far there is no traditional Chinese medicine preparation that can effectively reduce blood uric acid and treat gouty nephropathy.

Method used

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  • Medicinal composition for treating gout and preparation method thereof
  • Medicinal composition for treating gout and preparation method thereof
  • Medicinal composition for treating gout and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Take 15kg of Rehmannia, 15kg of Smilax, 5kg of Chinese Angelica, 15kg of Radix Paeoniae Rubra, 7.5kg of Haijinsha, 5kg of Alisma, 5kg of Atractylodes Rhizoma, and 5kg of Phellodendron Phellodendri. Add 8 times the amount of 70% ethanol to extract twice, combine the extracts, filter, recover ethanol under reduced pressure, concentrate under reduced pressure and dry at low temperature after no alcohol smell, and obtain alcohol extract; Shengdi, Smilax, Haijinsha and Ze Add 10 times the amount of water to decoct 3 times each time for diarrhea, combine the extracts, filter, concentrate, and dry to obtain the water extract; combine the alcohol extract and water extract, mix well, add excipients to granulate, dry, Add a small amount of magnesium stearate, mix well, put into capsules, and get ready.

Embodiment 2

[0067] Take 10kg of raw land, 10kg of Smilax smilax, 10kg of angelica, 10kg of red peony root, 10kg of Haijinsha, 5kg of Alisma, 5kg of Atractylodes macrocephala, and 5kg of Cortex Phellodendri. Extract 3 times with 10 times the amount of 70% ethanol, combine the extracts, filter, recover the ethanol under reduced pressure, concentrate at low temperature and reduced pressure after no alcohol smell, and dry to obtain the alcohol extract; Add 8 times the amount of water to decoct twice each time, combine the extracts, filter, concentrate, and dry to obtain the water extract; combine the alcohol extract and water extract, mix well, add auxiliary materials to granulate, dry, pack Put it into a bag to get the granules of the present invention.

Embodiment 3

[0069] Take 40kg of habitat, 40kg of Smilax smilax, 30kg of Angelica sinensis, 40kg of Radix Paeoniae Rubra, 40kg of Haijinsha, 20kg of Alisma, 20kg of Atractylodes macrocephala, and 20kg of Phellodendron Phellodendri. Extract 3 times with 10 times the amount of 70% ethanol, combine the extracts, filter, recover the ethanol under reduced pressure, concentrate at low temperature and reduced pressure after no alcohol smell, and dry to obtain the alcohol extract; Add 8 times the amount of water to decoct twice each time, combine the extracts, filter, concentrate, and dry to obtain the water extract; combine the alcohol extract and water extract, mix well, add excipients to granulate, and compress into tablets. Promptly get the pharmaceutical composition tablet of the present invention.

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Abstract

The invention relates to a medicinal composition for treating gout and a preparation method thereof, and belongs to the field of the pharmacy of Chinese medicines. The medicinal composition mainly comprises rehmannia root, glabrous greenbrier rhizome, Chinese angelica, red paeony root, Japanese climbing fern spore, oriental waterplantain rhizome, large-head atractylodes rhizome and pellodendron; and meanwhile, the invention also discloses the preparation method for the medicinal composition. The medicinal composition has the effects of tonifying kidney and nourishing yin, strengthening spleen and promoting dieresis, clearing heat and activating blood, treating stranguria and removing urinary calculus, and has an exact curative effect on hyperuricemia, gout and gouty hephropathy.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine and natural medicine, and in particular relates to a pharmaceutical composition for treating gouty nephropathy and a preparation method thereof. Background technique [0002] Gout is a group of diseases caused by long-term purine metabolic disorders, increased blood uric acid, and deposition of urate in the body. The clinical features are hyperuricemia, arthritis, tophi, urinary stones, and gouty nephropathy. In the early stage, acute gouty arthritis often occurs repeatedly, and severe joint pain seriously affects daily life and work. As gout recurs, the interval time gradually shortens, and the number of affected joints gradually increases. After 10 years of arthritis onset, characteristic gouty nodules may appear. The disease progresses and becomes chronic gouty arthritis, with bone pathological changes, joint stiffness and deformity; almost 100% of gout patients have renal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/90A61P19/06A61P13/12
Inventor 周瑾
Owner 周瑾
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