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Quality detecting method for traditional Chinese medicine Qianliening preparation

A technology for traditional Chinese medicines and preparations, which is applied in the field of quality inspection of traditional Chinese medicine Qianlenin preparations, can solve the problems that the quality of this product cannot be fully and accurately controlled, the quality inspection method of Qianlenin capsules is not found, and the quality standards need to be improved, so as to achieve enhanced product quality. Controllability, saving analysis time, and prolonging service life

Active Publication Date: 2012-09-12
JINHE TIBETAN MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing quality standards for Qianlenin medicines only use TLC thin-layer identification of a single medicinal material, antler antler, and HPLC to determine the content of gallic acid, a medicinal ingredient, and no other quality detection methods for Qianlenin capsules have been found in the prior art. Therefore, Existing quality inspection methods cannot comprehensively and accurately control the quality of this product, and the quality standard needs to be improved

Method used

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  • Quality detecting method for traditional Chinese medicine Qianliening preparation
  • Quality detecting method for traditional Chinese medicine Qianliening preparation
  • Quality detecting method for traditional Chinese medicine Qianliening preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0145] Embodiment 1: the identification method of Chinese medicine Qianlening Capsules

[0146] A. Identification of Myrobalan

[0147] Take 5g of the content of the Chinese medicine Qianlening capsule, add 25ml of absolute ethanol, ultrasonically treat for 30min, add 2g of diatomaceous earth, mix well, filter, and the filtrate is concentrated to 2ml, as the test solution; another 1g of myrobalan reference drug, Add 25ml of absolute ethanol, sonicate for 30min, add 2g of diatomaceous earth, mix well, filter, and concentrate the filtrate to 2ml as the reference drug solution; take another gallic acid reference substance, add methanol to make a solution containing 1mg per 1ml, As a reference solution; test according to thin-layer chromatography (Appendix VI B of "The Pharmacopoeia of the People's Republic of China" 2010 Edition), draw 5 μl of each of the above solutions, and place them on the same silica gel G thin-layer plate respectively. 6:4:1 chloroform-ethyl acetate-formic...

Embodiment 2

[0154] Embodiment 2: the assay method of Chinese medicine Qianlening Capsules

[0155] According to high performance liquid chromatography (Appendix VI D of Chinese Pharmacopoeia 2010 edition)

[0156] Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel is used as filler; acetonitrile is used as mobile phase A, 1% glacial acetic acid aqueous solution is used as mobile phase B, and gradient elution method is adopted: 0min →20min→25min→50min→55min→60min, according to the above time period, acetonitrile and 1% glacial acetic acid aqueous solution are eluted at the same time, among which, acetonitrile: 1%→1%→24%→24%→100% →1%; volume ratio of 1% glacial acetic acid aqueous solution: 99%→99%→76%→76%→0%→99%, use the detection wavelength of 275nm in 0min→20min, change the detection wavelength to 403nm in 20min , 21min to balance the detector, 21min→60min to use a detection wavelength of 403nm. The number of theoretical plates should not be less ...

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Abstract

The invention discloses a quality detecting method for traditional Chinese medicine Qianliening preparation. In the method, the quality standard of the existing traditional Chinese medicine Qianliening preparation is improved, and thin layer chromatography of myrobalan, safflower, pennycress seeds and radix et rhizoma rubies is added. According to the invention, the content of gallic acid and the content of hydroxyl safflower yellow A are simultaneously measured under the same chromatographic condition by adopting high performance liquid chromatography through varying the detection wave length of an ultraviolet detector. The thin layer chromatography has obvious characteristic spots and strong specificity. The high performance liquid chromatography is simple and practicable, has better accuracy and precision and can effectively ensure the preparation quality.

Description

technical field [0001] The invention relates to a quality detection method of a traditional Chinese medicine preparation, in particular to a quality detection method of a traditional Chinese medicine Qianlenin preparation. Background technique [0002] Qianlening Capsule is an exclusive product of Jinhe Tibetan Medicine Co., Ltd., which is recorded in the national standard part of the local standard of Chinese patent medicine, standard number: WS-10627(ZD-0627)-2002-2011Z. Qianlening Capsules are made of medicinal materials with the following weight ratios: 58.7g of 菥蓂子, 41.2g of Shiwei, 41.2g of dandelion, 29.3g of juniper, 29.3g of myrobalan, 22.8g of sword bean, 17.5g of mango seed, Rose apple 17.5g, Datuo Ye Yunshi 17.5g, comfrey antler 11.4g, Tibetan madder 17.5g, safflower 11.4g, cardamom 5.9g. The above thirteen flavors are crushed into fine powder, sieved, mixed evenly, packed into capsules, and made into 1000 capsules. It has the effects of clearing away heat and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90G01N30/02
Inventor 孙绪丁刘玉芹江玉娟任松鹏周忠山
Owner JINHE TIBETAN MEDICINE
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