Emulsion-in-water insecticide and production process thereof

Abstract

The invention discloses an emulsion-in-water insecticide and a production process thereof. The preparation comprises the following components in percentage by weight: 0.5-50% of active pharmaceutical ingredient, 8-15% of methylnaphthalene, 0-5% of isophorone, 0-5% of cyclohexanone, 2-8% of triphenylethyl phenol polyoxyethyl ether, 0-3% of calcium dodecylbenzene sulfonate, 0-2% of 1,2-benzisotniazol-3(2H)-one, 5-10% of sucrose, 0-10% of ethylene glycol, 0.5% of acetic acid and the balance of water. The preparation method comprises the following steps of: dissolving the active pharmaceutical ingredient, preparing mother liquor, and performing a shearing process. The emulsion-in-water insecticide disclosed by the invention has the advantages of wide range of application, stable formulation, obvious synergy and simple production process.

Description

technical field [0001] The invention relates to a water-emulsion insecticide, in particular to a water-emulsion insecticide and a production process thereof, belonging to the field of water-emulsion insecticides. Background technique [0002] The international code name of water emulsion dosage form is Ew, which was once called concentrated emulsion (Concentrate Emulsion). It is a preparation made by mixing liquid or mixed with a solvent to disperse the liquid pesticide original drug in water with small droplets of 0.5-1.5 microns. The appearance is milky white milk-like liquid. Generally speaking, the water solubility of the pesticide used to process the water emulsion is expected to be below 1000mg / L. Pesticides that are not sensitive to hydrolysis are easily processed into chemically stable aqueous emulsions due to the large amount of water in the formulation. Pesticides such as organophosphorus and carbamates are easily hydrolyzed, but through the selection of emulsifi...

AI Technical Summary

Problems solved by technology

[0004] (1) Short storage stability time: the normal storage time of pesticides is 2-3 years, while the normal storage time of water emulsion is about 1 year;

[0005] (2) Stratification is easy to occur: it will break the emulsion due to temperature, physical and chemical changes of the original drug and additives, ultraviolet rays, time, water quality, etc., that is, the separation of water and solvent to form stratification;

[0006] (3) Precipitation is prone to occur: due to the decomposition of auxiliary agents and the original drug, the original drug will be dropped out of the preparation, forming rice grains or crystals and sinking to the bottom, which will greatly reduce the efficacy and safety of the product. content of active ingredients;

[0007] (4) It is difficult to solve the problem of pesticide synergy: since water is the main solvent, the formation of water emulsion is a principle of dynamic stability. , is extremely unstable in this dosage form. Therefore, the surface swelling force of the normal dosage form of water-emulsion is similar to that of water. Poor adhesion and penetration are the biggest problems of water-emulsion, and it is difficult to improve the efficacy of the product.

[0008] (5) Emulsion in water is easy to freeze in winter, especially in northern my country where the temperature is lower than 15°C, which greatly limits the development of this formulation