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Preparation method of colistin sulfate premixing agents

A technology of colistin sulfate and premix, which is applied in the direction of polymyxin, chemical instruments and methods, antibacterial drugs, etc., and can solve the loss of colistin sulfate, waste of cell protein resources, increase of concentrated liquid pigment, etc. Problems, to achieve the effect of low production cost, reasonable product structure and cheap price

Active Publication Date: 2012-07-25
江苏赛奥生化有限公司
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AI Technical Summary

Problems solved by technology

The shortcoming of above-mentioned preparation process is: in the wet fungus residue that produces in the production process of colistin sulfate crude drug, be classified as dangerous solid waste because of containing antibiotic colistin sulfate, need incineration treatment, processing cost is big, and causes secondary pollution, simultaneously Cause waste of bacterial protein resources
In the preparation process of colistin sulfate premix, the bacteria in the fermentation liquid are directly concentrated, which may easily cause the loss of colistin sulfate, and also increase the pigment of the concentrate

Method used

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Embodiment Construction

[0014] Take 1000L of colistin sulfate fermentation broth, the wet cell content is 16%, the fermentation unit is 550,000 u / ml, and the total fermentation volume is 550 billion.

[0015] Adjust the pH of the colistin sulfate fermentation broth to 4.5-5.0 with sulfuric acid, filter through plates and frames, and re-filter to obtain 160 kg of wet fungus residue and 840 L of filtrate. The colistin sulfate content in the wet mushroom residue was 426,250 u / mg, totaling 68.2 billion, and the colistin sulfate content in the filtrate was 573,600 u / ml, totaling 481.8 billion. Take 420L of the filtrate and concentrate it through a double-effect concentrator. The first-effect evaporation temperature is 80-90°C, the second-effect evaporation temperature is 65-75°C, and 252L of water is evaporated to obtain a concentrated solution of 168L with a content of 1,433,900 u / ml. 240.9 billion. The concentrated solution is mixed with the wet fungus residue, and the total dry matter content in the m...

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Abstract

The invention discloses a preparation method of colistin sulfate premixing agents. The PH of the colistin sulfate fermentation liquid is regulated to 4.5 to 5.0 by sulfuric acid, the plate frame filtering and the re-filtering are carried out to obtain wet germ slag and filter liquid, the filter liquid is concentrated by a dual-effect concentrator, and the concentration liquid is obtained; the concentration liquid and the wet germ slag are mixed into mixed liquid, ground limestone and defatted rice bran are added into the mixed liquid, the materials are uniformly mixed, and a mixture is obtained; and the mixture is subjected to expansion drying, the air inlet temperature of expansion drying agents is controlled to be 125 to 135 DEG C, the air outlet temperature is 60 to 70 DEG C, and finished products of the colistin sulfate premixing agents are obtained. The preparation method provided by the invention has the advantages that the utilization rate is high, the yield is high, and the operation is easy.

Description

technical field [0001] The invention relates to a method for preparing a colistin sulfate premix. Background technique [0002] Colistin sulfate has a significant antibacterial effect on most Gram-negative bacteria such as Pseudomonas aeruginosa, Escherichia coli, Salmonella, Shigella, and Bordetella pertussis, and is the drug of choice for common intestinal diseases such as intractable dysentery in livestock and poultry. The domestic colistin sulfate finished products include colistin sulfate raw material medicine and colistin sulfate premix. The liquid is adsorbed and analyzed by resin; the analyzed liquid is desalted by resin, decolorized by activated carbon, concentrated by nanofiltration, and spray-dried to obtain the finished product. The preparation process of colistin sulfate premix is ​​as follows: the fermented liquid is directly double-effect concentrated after pH adjustment, then corn starch and other auxiliaries are added, emulsified and pulped, sprayed, granul...

Claims

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Application Information

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IPC IPC(8): A61K38/12C07K7/62A61P31/04
Inventor 林永彬田歌雷虹韩勤更
Owner 江苏赛奥生化有限公司
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