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Use of extracts from salonum glaucophyllum for treating bone metabolism disorders and kidney disorders

A technology of bone metabolism disorder and green leaves, applied in the field of nutrition, can solve problems such as impaired health, inappropriate dosage, and inability to carry out the daily dosage

Inactive Publication Date: 2012-07-18
HERBONIS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dosing is therefore often inappropriate; the recommended daily administration is often not followed through, with the result that overall health is increasingly impaired

Method used

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  • Use of extracts from salonum glaucophyllum for treating bone metabolism disorders and kidney disorders
  • Use of extracts from salonum glaucophyllum for treating bone metabolism disorders and kidney disorders
  • Use of extracts from salonum glaucophyllum for treating bone metabolism disorders and kidney disorders

Examples

Experimental program
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preparation example Construction

[0029] The method of preparation briefly disclosed above makes it possible to obtain plant extracts that are truly alkaloid-free relative to Solanum viridis, or in other words, alkaloids absolutely below detection levels so that said extracts are not or cannot be suspected of being due to excess or non-existence. Undesirable side effects are exhibited in controlled amounts of the alkaloids.

[0030] Also present in the plant extract is quercetin glycoside, which in situ interacts with the aforementioned 1,25-dihydroxyvitamin D 3A combination of glycosides works; quercetin glycosides mainly contain rutin, apirosyl rutin, hyperoside, isoquercitrin and other trace amounts of quercetin oligoglycosides.

[0031] The present invention provides a method for preventing or treating human skeletal or musculoskeletal metabolic disorders or correcting human renal dysfunction. The method includes providing the above-mentioned prevention or treatment to a subject in need: As the bone metabo...

Embodiment 1

[0046] Embodiment 1: the preparation of powdery nightshade plant extract

[0047] a) Soaking variant

[0048] Selected batches of dried leaves of Solanum solani were soaked with stirring for about 24 hours using a water / ethanol mixture ranging from 5 liters / kg to 12 liters / kg at 40°C to 60°C.

[0049] Based on previous studies of 1,25-dihydroxyvitamin D in various batches of dry leaf material available in warehouses 3 Analytical evaluation of glycoside content, preparation of 85 vol / 15 vol ** water / ethanol mixture. Use the right mix to get the vitamin D you need 3 Derivative content (approximately 100ppm in this example), and required 1,25-dihydroxyvitamin D 3 Ratio of glycosides and quercetin glycosides. The liquid portion was separated and stored while a second soak of 24 hours was repeated.

[0050] ( ** Similar results have been obtained using mixtures containing about 20% to 40% ethanol)

[0051] The collected water / ethanol extracts were then combined, ascorbic ac...

Embodiment 2

[0059] Example 2: Calcium-enriched milk

[0060] Calcium-enriched liquid milk was prepared by mixing 10 liters of tap water with 1200 g of part-skimmed milk powder and 40 g of calcium magnesium carbonate (activated dolomite) at room temperature. 20 g of the plant extract of Example 1 were then gradually poured into the reconstituted milk, and the resulting liquid was divided into portions of 250 ml each and finally stored in a refrigerator.

[0061] Each serving of reconstituted milk contains approximately 500 mg of plant extract, which represents half of the recommended appropriate daily dosage for persons suffering from or suspected of suffering from senile osteoporosis, osteopenia or postmenopausal women.

[0062] It has been observed that reconstituted milk is well received in terms of taste and flavor. Sugar, cocoa powder or soluble coffee powder can be added to each person's personal taste; the milk or milk-based drink can also be heated if desired.

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Abstract

A method is provided for preventing or treating bone or musculoskeletal metabolism disorders or kidney malfunction in humans. It comprises providing to a subject in need of that a calcium containing or calcium enriched diet combined with the administration of an efficient amount of a plant extract of Solatium glaucophyllum comprising from about 0.8 to about 2.2 weight % of a mixture of 1,25-dihydroxyvitamin D3 glycosides and quercetin glycosides present in a ratio of about 1 : 100 to 1 :200 parts by weight. There are also provided food or dietary composition and food supplement designed for preventing or treating bone or musculoskeletal metabolism disorders or kidney malfunction in humans which comprises an efficient amount of the said plant extract of Solanum glaucophyllum and a source of calcium.

Description

technical field [0001] The present invention relates to the field of nutrition, more specifically to a nutrition method for preventing and treating human specific moderate to severe bone or musculoskeletal metabolic diseases. Background technique [0002] In recent decades, the average age and life expectancy of human beings, especially those in the West, have continued to increase, so that people over the age of 65, and then over 75 and even over 85 account for a considerable portion of the global population. Experts expect Western countries to grow this population segment to 20% in the next 20 years, which will lead to a situation where there will be a clear parallel increase in related social or health problems. [0003] With regard to the development of the health status of this particular segment of the population, rapid increases in several physical and mental diseases or conditions have been noted, such as diabetes, Alzheimer's disease or age-related diseases (such as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61P3/14A61P19/10A61P13/12
CPCA61K36/81A61P13/12A61P19/08A61P19/10A61P3/00A61P3/02A61P3/14
Inventor H·巴赫曼S·奥特岑
Owner HERBONIS
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