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Fingerprint spectrum determination method of ligusticum wallichii tea-blending granular preparation

A Chuanxiong tea preparation and assay method technology, applied in the direction of measuring devices, instruments, scientific instruments, etc.

Active Publication Date: 2012-07-18
GUIZHOU WARMEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many methods for the determination of ferulic acid and glycyrrhizic acid in this product, but how to use the fingerprint identification method from a more macroscopic point of view to control the various chemical components in Chuanxiong Chatiao Granules has not been seen. Reports are also expected by those skilled in the art

Method used

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  • Fingerprint spectrum determination method of ligusticum wallichii tea-blending granular preparation
  • Fingerprint spectrum determination method of ligusticum wallichii tea-blending granular preparation
  • Fingerprint spectrum determination method of ligusticum wallichii tea-blending granular preparation

Examples

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Effect test

preparation example 1

[0114] Preparation Example 1: Preparation of Extract

[0115] Composition of raw materials:

[0116] 120 parts by weight of Rhizoma Chuanxiong, 60 parts by weight of Angelica dahurica,

[0117] Notopterygium 60 parts by weight, licorice 60 parts by weight,

[0118] Windproof 45 parts by weight, Asarum 30 parts by weight,

[0119] Mint 240 parts by weight, Schizonepeta 120 parts by weight.

[0120] Preparation method: (1) Take Rhizoma Chuanxiong, Angelica dahurica, Notopterygium, Asarum, Fangfeng, Licorice, add water to decoct, filter the decoction, and reserve the medicinal liquid; (2) Extract volatile oil from mint and Schizonepeta, set aside; filter the aqueous solution, The filtrate is combined with the medicinal liquid obtained in step (1); (3) the combined medicinal liquid obtained in step (2) is concentrated and dried to make extract powder; (4) the volatile oil obtained in step (2) is evenly mixed with Add it into the extract powder obtained in step (3) to obtain ...

preparation example 2

[0122] Preparation Example 2: Preparation of extracts excluding volatile oils

[0123] Composition of raw materials:

[0124] 120 parts by weight of Rhizoma Chuanxiong, 45 parts by weight of Angelica dahurica,

[0125] Notopterygium 45 parts by weight, licorice 75 parts by weight,

[0126] Windproof 33 parts by weight, Asarum 38 parts by weight,

[0127] Mint 300 parts by weight, Nepeta 90 parts by weight.

[0128] Preparation method: basically the same as Preparation Example 1, the difference is: in step (1), decoct in water twice, decoct in water for 1.5 hours with 6 times the amount of materials used for the first time, and decoct with 6 times the amount of materials used for the second time Fry for 1.5 hours.

preparation example 3

[0129] Preparation Example 3: Preparation of extracts excluding volatile oils

[0130] Composition of raw materials:

[0131] 120 parts by weight of Rhizoma Chuanxiong, 75 parts by weight of Angelica dahurica,

[0132] Notopterygium 75 parts by weight, licorice 45 parts by weight,

[0133] Windproof 56 parts by weight, Asarum 22 parts by weight,

[0134] 180 parts by weight of Peppermint, 150 parts by weight of Schizonepeta.

[0135] Preparation method: basically the same as Preparation Example 1, the difference is: in step (1), decoct in water once, and use 10 times the amount of medicinal materials to decoct in water for 3 hours.

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Abstract

The invention relates to a fingerprint spectrum determination method of a ligusticum wallichii tea-blending granular preparation, which comprises the following steps: (a) preparing ligusticum wallichii tea-blending preparation test sample: precisely weighing a proper quantity of ligusticum wallichii tea-blending preparation, adding a solvent for reflux extraction, centrifuging the extracting solution, evaporating and drying supernate, dissolving with water, extracting with n-butyl alcohol, collecting n-butyl alcohol extracting solution, evaporating and drying, dissolving with 70% methyl alcohol, and filtering by using a microfiltration membrane to obtain the test sample; (b) chromatograph condition: with octadecylsilane bonding silica gel as the chromatograph column of filler, carrying out gradient elution, wherein a flowing phase A is acetonitrile, the flowing phase B is 0.01-0.2% formic acid aqueous solution, and the detection wavelength is 230-280nm; and (c) determination: precisely adsorbing test sample solution, introducing in a liquid chromatograph, recording the chromatogram to finally obtain the characteristic fingerprint spectrum of the ligusticum wallichii tea-blending preparation. The HPLC (High Performance Liquid Chromatography) characteristic fingerprint spectrum analysis method for ligusticum wallichii tea-blending preparations, such as the granular preparation, is simple to operate, has the advantages of high precision and repeatability, and is suitable for controlling the quality of the ligusticum wallichii tea-blending preparations, such as the granular preparation.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to a method for measuring the fingerprints of Chuanxiong teatiao granule preparations, in particular to a method for measuring characteristic components in Chuanxiong teatiao granule preparations by using a high-performance liquid chromatography (HPLC) fingerprint identification method. Background technique [0002] The original prescription of Chuanxiong Chatiao Granules comes from the "Taiping Huimin Heji Bureau Prescription" of the Song Dynasty. It has the effect of dispelling wind and relieving pain. It is used for headache due to wind pathogens, or aversion to cold, fever, and nasal congestion. This prescription is mainly composed of Chuanxiong, Nepeta, Fangfeng, Asarum, Angelica, notopterygium, mint, and licorice (see, Lin Xiaolan. Analysis of the clinical application of Chuanxiong Chatiao Granules [J]. Beijing Traditional Chinese Medicine, 2004, 23(3): 190 ...

Claims

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Application Information

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IPC IPC(8): G01N30/88G01N30/06
Inventor 梁斌李孟林张丽艳谢宇唐靖雯潘梅梅基雄
Owner GUIZHOU WARMEN PHARMA
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