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Keratoprosthesis and preparation method thereof

A kind of artificial cornea and nanotechnology, applied in medical science, prosthesis, eye implants, etc., can solve the problem of poor compatibility between artificial cornea and tissue, achieve good biocompatibility and anti-infection, and promote rapid healing Effect

Active Publication Date: 2012-07-18
深圳华明生物科技有限公司
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  • Summary
  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide an artificial cornea with antibacterial activity and its preparation method to solve the problems of poor compatibility between traditional artificial cornea and tissue

Method used

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  • Keratoprosthesis and preparation method thereof
  • Keratoprosthesis and preparation method thereof

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preparation example Construction

[0018] The preparation method of the artificial cornea of ​​this antibacterial activity comprises the steps:

[0019] Step 1, polyvinyl alcohol, chitosan derivative (this chitosan derivative can be 6-O-carboxymethyl chitosan, chitosan quaternary ammonium salt or chitosan), nano-phosphate, preparation Pore ​​agent and organic solvent (dimethyl sulfoxide, DMSO for short) are mixed according to the mass ratio of 1-3:0.5-2:0.5-2:5-20:5-20, heated and stirred evenly, injected into the hollow mold, adjusting the thickness, molding, freezing at -20 to -40°C for 10-48 hours, thawing at room temperature for 2-6 hours, repeating the freezing-thawing process four times to obtain the scaffold material precursor;

[0020] Step 2. Mix polyvinyl alcohol, organic solvent and water uniformly in a mass ratio of 1-3:5-20:1-3, inject into the hollow part of the mold and spread it on the back of the scaffold material precursor to form a film Freezing at -20~-40°C for 10-48 hours, thawing at room ...

Embodiment 1

[0024] (1), mix polyvinyl alcohol, 6-O-carboxymethyl chitosan, nano tricalcium phosphate, sodium chloride and organic solvent DMSO in a mass ratio of 1:0.5:0.5:5:5, heat and stir Uniformly, pour into a hollow mold, adjust the thickness, and mold; freeze at -20°C for 48 hours, thaw at room temperature for 2 to 6 hours, repeat the freezing-thawing process four times, and obtain the scaffold material precursor. (2) Mix polyvinyl alcohol, DMSO and water uniformly in a mass ratio of 1:10:1, inject into the hollow part of the above-mentioned mold and extend it to form a film on the back of the scaffold material precursor; freeze at -20°C for 48 hours, thawing at room temperature for 2-6 hours, repeating the freezing-thawing process four times, so that the optical center part and the porous peripheral scaffold part form crosslinking, and form a non-water-permeable coating film on the back of the scaffold material precursor. (3) Soak the non-water-permeable coating film in water for 5...

Embodiment 2

[0026] (1), mix polyvinyl alcohol, 6-O-carboxymethyl chitosan, nano tricalcium phosphate, sodium chloride and organic solvent DMSO in a mass ratio of 2:0.5:1:10:15, heat and stir Uniformly, pour into a hollow mold, adjust the thickness, and mold; freeze at -20°C for 48 hours, thaw at room temperature for 2 to 6 hours, repeat the freezing-thawing process four times, and obtain the scaffold material precursor. (2) Mix polyvinyl alcohol, DMSO and water uniformly in a mass ratio of 2:10:2, inject into the hollow part of the above-mentioned mold and extend it to form a film on the back of the scaffold material precursor; freeze at -20°C for 48 hours, thawing at room temperature for 2-6 hours, repeating the freezing-thawing process four times, so that the optical center part and the porous peripheral scaffold part form crosslinking, and form a non-water-permeable coating film on the back of the scaffold material precursor. (3) Soak the non-water-permeable coating film in water for 5...

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Abstract

The invention discloses a keratoprosthesis. The keratoprosthesis has antibacterial activity. The keratoprosthesis comprises a porous peripheral support part and an optical center part. The porous peripheral support part comprises an antibacterial chitosan derivative, polyvinyl alcohol and a nano-phosphate. The optical center part comprises polyvinyl alcohol hydrogel and hydroxyethyl methacrylate hydrogel. The invention also discloses a preparation method of the keratoprosthesis. The keratoprosthesis has good biocompatibility and infection resistance and can promote fast healing of surgical wounds.

Description

technical field [0001] The invention belongs to the technical field of implant materials and artificial organs in medical instruments, and in particular relates to an artificial cornea with antibacterial activity and a preparation method thereof. Background technique [0002] Corneal disease is a common and frequently-occurring disease in ophthalmology, and the blinding rate of corneal disease ranks second among blinding factors. Most corneal diseases can be relieved of blindness through corneal transplantation. However, the source of donor cornea is difficult, and some corneal diseases (such as severe dry eye disease) cannot be used for allogeneic keratoplasty. last hope. [0003] The main problem of artificial cornea transplantation at present is that most artificial corneas can only be used in the field due to the poor biocompatibility between biological tissues and heterogeneous materials, or the rejection of the body, or the poor mechanical stability. It remains in th...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/16A61L27/12A61F2/14
Inventor 罗仲宽周莉周金生姚晓明于莉欧阳君君郑家庆
Owner 深圳华明生物科技有限公司
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