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Compound amino acid injection for livestock as well as preparation method and applications thereof

A technology of compound amino acid and injection, which is applied in the field of animal compound amino acid injection and its preparation, which can solve the problems of strengthening and shortening the treatment time of diseases, and the easy oxidation and discoloration of injections, so as to promote secretion, shorten the treatment time of diseases, enhance the The effect of animal fitness

Active Publication Date: 2014-09-24
HEBEI KEXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention is prepared by using 18 kinds of amino acids and γ-aminobutyric acid required by animal bodies. During the preparation process, disodium ethylenediamine tetraacetate is used to complex metal ions in water. The problem of easily oxidized and discolored injections and the stable pH value of the reaction system, the present invention can not only timely supplement the essential amino acids and non-essential amino acids required by the animal body during the onset of the disease, but also enhance the animal's physical fitness and shorten the treatment time of the disease.

Method used

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  • Compound amino acid injection for livestock as well as preparation method and applications thereof
  • Compound amino acid injection for livestock as well as preparation method and applications thereof
  • Compound amino acid injection for livestock as well as preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0029] The following examples are respectively a compound amino acid injection for livestock and its preparation method, wherein the active ingredients in the injection of each example (in parts by weight, per 1000 mL of injection) are shown in the following table:

[0030]

[0031] Example 1 The preparation method of animal compound amino acid injection is carried out according to the following steps:

[0032] (1) Take 60% of the total amount of water for injection, put it in a concentrated tank, heat and boil for 10 minutes, and inject CO 2 The airflow controls the water temperature at 75°C, in CO 2 Add disodium edetate and sodium bisulfite under the protection of gas flow and stir to dissolve completely.

[0033] (2) in CO 2 Under the protection of gas flow, add histidine and arginine and stir until dissolved, then add the formula amount of leucine, isoleucine, lysine, phenylalanine, threonine, valine, methionine, Glycine, alanine, proline, tyrosine, serine, asparti...

Embodiment 5

[0043] Example 5 The quality detection of animal compound amino acid injection in embodiment 1-4

[0044] In this example, the quality inspection was carried out on the compound amino acid injection for animals prepared in the above-mentioned Examples 1-4. The specific detection method is as follows:

[0045] The accelerated test is placed under the conditions of temperature 40±2°C and relative humidity 75±5% for 6 months, and samples are taken at the end of the 0th month, 1st month, 2nd month, 3rd month and 6th month during the test period, according to The quality standard of "State Food and Drug Administration Drug Standards" WS1-(X-324)-2003Z has been tested, and the results are shown in Table 1:

[0046]

[0047] The above test results show that there is no obvious change in the indicators of the sample, and the quality of the sample is stable.

Embodiment 6

[0048] Example 6 The application of the animal compound amino acid injection prepared by embodiment 1-4

[0049] The veterinary compound amino acid injection prepared respectively in Examples 1-4 is applied to experimental animals, and the specific method is as follows:

[0050] ① Application in the treatment of bovine viral diarrhea

[0051] Young cattle are more susceptible to bovine viral diarrhea, and generally show mild symptoms, but sometimes a sudden outbreak occurs, and the whole herd shows severe symptoms. The clinical symptoms of the acute type are sudden fever, body temperature rises to 40--42°C, leukopenia, less food or food refusal, cessation of rumination, rapid breathing and heartbeat, cough, runny nose, oral mucosa flushing, increased saliva, and then erosion, The diarrhea is watery and lasts for several days, with air bubbles and blood mixed in the stool. Severe cases died of dehydration and exhaustion. The course of the disease is 1-3 weeks, and the mort...

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Abstract

The invention discloses a compound amino acid injection for livestock and its preparation method and application. The main components of the injection are composed of 18 kinds of amino acids required by the animal body and γ-aminobutyric acid. During the preparation process, disodium ethylenediamine tetraacetate is used to complex metal ions in water, and the carbon dioxide gas flow is injected during the entire production process. It solves the problem of easily oxidized and discolored injections and stabilizes the pH value of the reaction system. The invention can timely supplement the essential amino acids and non-essential amino acids required by the animal body during the onset of the disease, enhance the animal's physical fitness, shorten the treatment time of the disease, and the added γ -GABA can reduce energy consumption by reducing unconscious movement of animals, promote the secretion of gastric juice and increase feed intake. The invention is used for the body repairing during the disease treatment and post-ill recovery period of livestock animals.

Description

technical field [0001] The invention belongs to the technical field of animal husbandry and veterinary medicine, and relates to an injection and a preparation method and application thereof, in particular to a compound amino acid injection for livestock and a preparation method and application thereof. Background technique [0002] At present, in the domestic industry, glucose injection, sodium chloride injection and glucose sodium chloride injection are the most used body fluid supplements for enhancing animal physical fitness during the treatment of animal diseases. These three injections can replenish water, energy and It can regulate the electrolyte balance of the body, but it cannot improve the nutritional status of the animal body and supplement the amino acids required by the animal body to regulate the feed intake of the animal. During the disease period of animals, most of them show decreased appetite, reduced feed intake, weak body, and a large loss of nutrients in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4172A61K31/405A61K31/401A61K31/198A61P3/02
Inventor 陈淑芳田会彦赵素娟赵静茹
Owner HEBEI KEXING PHARMA
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