Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of magnesium-hydroxyapatite/polylactic acid composite molding material

A hydroxyapatite and composite molding technology, which is applied in medical science, prosthesis, etc., can solve the problems of affecting the mechanical properties and degradation rate of composite materials, reducing the mechanical strength of composite materials, and reducing the clinical application scope of materials, etc. Mechanical properties and degradation rate, avoid melt blending, ensure the effect of bone repair application range

Inactive Publication Date: 2012-06-20
TIANJIN UNIVERSITY OF TECHNOLOGY
View PDF4 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

First, the size uniformity and dispersion uniformity of HA particles in the PLA matrix: 1) Chinese patent 200710032725.9 discloses a method for preparing HA / PLA composite materials based on the hot melt blending method, but the prepared materials have obvious defects. Partial agglomeration phenomenon; 2) Chinese patent 200910153388.8 discloses a solution blending method, which improves the dispersion of HA, but the HA particles used in this method are relatively large due to hard agglomeration, and the physical dispersion method , it is difficult to completely disperse it into particles of relatively uniform size, which to a large extent affects the balanced mechanical properties and degradation rate of the composite material, and affects the clinical use effect; 3) Chinese patent 201010557114 uses gelatin to prepare HA into a hydrosol , mixed with an organic solvent dissolved in PLA, but this method introduces gelatin components, which will cause holes in the material when the material is molded later
Secondly, in the preparation process, it is easy to cause unnecessary loss of PLA molecular weight
Because when adding Mg, the conventional method is to use a twin-screw extruder to granulate or a torque rheometer to melt blend, but its working temperature is higher, close to the PLA decomposition temperature
The loss of the molecular weight of PlA reduces the mechanical strength of the composite material, accelerates the degradation rate of the material, and reduces the clinical application range of the material

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A preparation method of magnesium-hydroxyapatite / polylactic acid composite molding material, the steps are as follows:

[0025] 1) 11.735g Ca(NO 3 ) 2 4H 2 O and 6.066g (NH 4 ) 3 PO 4 ·3H 2 O were made into 100 mL aqueous solution with deionized water, Ca(NO 3 ) 2 4H 2 O aqueous solution was poured into a three-necked flask, heated to 90°C, adjusted to pH 8-9 with NaOH, and added dropwise at a rate of 1 drop / second (NH 4 ) 3 PO 4 ·3H 2 O aqueous solution was stirred at the same time. After the dropwise addition, the mixed solution was continuously stirred at 90°C for 30 minutes, then slowly cooled to 60°C and maintained for 30 minutes. After removing the upper layer of water, the concentration of 0.125g / ml hydroxyapatite ( HA) in aqueous solution, the size of HA is 0.1 - 100μm;

[0026] 2) Dissolve 93.5g of polylactic acid (PLA) with a molecular weight of 400,000 in tetrahydrofuran at a concentration of 0.2g / ml at 63°C. After stirring evenly, add the aqueou...

Embodiment 2

[0030] 1) The steps are the same as 1) in Example 1, and a solution containing 10g HA is prepared;

[0031] 2) The steps are the same as 2) in Example 1, but the molecular weight of racemic polylactic acid is 600,000, and the organic solvent is chloroform;

[0032] 3) The steps are the same as 3) in Example 1, but the amount of magnesium powder is 3g.

[0033] 4) Put the composite material prepared in 3) into a cavity with a diameter of 10mm, heat it to 180°C, and hold it under a mold pressure of 15MPa for 10 minutes. After cooling, the preformed material is obtained. Warm to 80°C, keep under 15MPa pressure for 10min, and after cooling, the molding material is obtained.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention relates to a preparation method of a magnesium-hydroxyapatite / polylactic acid composite molding material. The preparation method comprises the following steps that: PLA is dissolved in organic solvent, the prepared hydroxyapatite solution is directly fully mixed with the organic solvent dissolved with polylactic acid, then HA / PVA composite is prepared by means of volatilizing and drying the solvent, the composite is dissolved in the organic solvent and is added with M9 powdery particles for intensive mixing, then the magnesium-hydroxyapatite / polylactic acid composite material isobtained by volatilizing and drying the solvent, and finally the magnesium-hydroxyapatite / polylactic acid composite material is molded by injection molding or mold pressing technology. The preparation method provided by the invention has the advantages that the M9-HA / PLA composite material is prepared by the solution blending technology, the dispersible uniformity and the biocompatibility of magnesium and hydroxyapatite in the polylactic acid are improved, the loss of molecular weight of polylactic acid in the preparation process is reduced, the balanced dynamics performance and the degradation rate of the material are guaranteed, and the preparation method is much more applicable to clinical bone repair; in addition, the preparation method is simple in technology and low in cost and is much more suitable for productization production.

Description

technical field [0001] The invention relates to the technical field of preparation of materials for medical surgery, in particular to a preparation method of a magnesium-hydroxyapatite / polylactic acid composite molding material. Background technique [0002] At present, in the field of treatment of fractures and bone trauma, polylactic acid (PLA) materials have been widely used in the preparation of tissue engineering scaffolds due to their good biodegradability and absorbency, and are one of the most widely used bone internal fixation materials so far. However, the pure PLA fracture internal fixator can't meet the bone fixation requirements very well, so it needs to be combined with other materials to meet the clinical requirements. Combining metal magnesium and hydroxyapatite (HA) with PLA is a new design of degradable implant material. Magnesium (Mg) has good biocompatibility, and its corrosion degradation is alkaline. Combining it with PLA materials can neutralize the l...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08K3/32C08K3/08C08J3/215A61L27/46A61L27/18A61L27/12A61L27/04B29C45/03B29C45/78
Inventor 刘德宝唐怀超
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com