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Bead-shaped amphipathic nano particle as well as preparation method and application thereof

A nanoparticle and amphiphilic technology, which is applied in the field of beaded nanoparticles and its preparation, can solve the problem of less research on the synthesis of non-spherical polymer nanoparticles, complex preparation process of non-spherical amphiphilic nanoparticles, and polymer micelles. Poor stability and other problems, to achieve the effect of simple and easy preparation process, long storage time at room temperature and good stability

Inactive Publication Date: 2012-06-20
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the preparation and application of non-spherical nanoparticles mainly focus on inorganic nanoparticles, such as gold nanoparticles and carbon nanotubes; the synthesis of non-spherical polymer nanoparticles is less
Gratton et al. used various acrylate derivatives and methyl acrylate derivatives as raw materials to prepare nanoparticles of different shapes by PRINT technology (Proc. Natl. Acad. Sci. USA, 2008, 105(33):11613-11618), However, the preparation process of these nanoparticles is complicated, and there is no amphiphilicity, so the application is limited
Geng et al. used polyethylene glycol, polyn-butylene and polycaprolactone as raw materials to prepare amphiphilic filamentous micelles by block copolymerization (Nat. Nanotechnol., 2007, 2(4): 249- 255), but the poor stability of polymer micelles limits the application
The existing non-spherical amphiphilic nanoparticles have disadvantages such as complicated preparation process and poor stability
For beaded nanoparticles, there is no report

Method used

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  • Bead-shaped amphipathic nano particle as well as preparation method and application thereof
  • Bead-shaped amphipathic nano particle as well as preparation method and application thereof
  • Bead-shaped amphipathic nano particle as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1: carboxymethyl chitosan nanoparticle

[0055] Weigh 1 g of carboxymethyl chitosan (10,000 Daltons), put it in a flask, add 98 ml of double distilled water, stir to dissolve, heat to 45 °C, add 1 ml of methyl methacrylate, and add after 20 min 1 ml of 5% ammonium persulfate was heated to 72 °C, and the reaction was continued for 24 h. The resulting suspension was dialyzed against a semipermeable membrane with a molecular weight cut-off of 14,000 Daltons. The particle size was measured to be 243.7 nm.

Embodiment 2

[0056] Embodiment 2: beaded carboxymethyl chitosan nanoparticles

[0057] Weigh 0.25 g of carboxymethyl chitosan (10,000 Daltons), put it in a flask, add 25 ml of double distilled water, stir to dissolve, heat to 45 °C, add 0.25 ml of methyl methacrylate, and add after 20 min 0.25 ml of 5% ammonium persulfate was heated to 72 °C, and glutaraldehyde was added for 1.5 h to a final concentration of 0.15% (v / v), and the reaction was continued for 12 h. The resulting suspension was dialyzed against a semipermeable membrane with a molecular weight cut-off of 14,000 Daltons. The particle size of a single sphere in the beads was measured to be 159.8 nm.

Embodiment 3

[0058] Embodiment 3: beaded carboxymethyl chitosan nanoparticles

[0059] Weigh 0.25 g of carboxymethyl chitosan (150,000 Daltons), put it in a flask, add 25 ml of double distilled water, stir to dissolve, heat to 45 °C, add 0.25 ml of methyl methacrylate, and add after 20 min 0.25 ml of 5% ammonium persulfate was heated to 72 °C, and glutaraldehyde was added for 1 h to a final concentration of 0.15% (v / v), and the reaction was continued for 12 h. The resulting suspension was dialyzed against a semipermeable membrane with a molecular weight cut-off of 14,000 Daltons. The particle size of a single sphere in the beads was measured to be 191.3 nm.

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Abstract

The invention belongs to the technical field of nano materials, and in particular relates to a bead-shaped amphipathic nano particle as well as a preparation method and an application thereof. The bead-shaped amphipathic nano particle is prepared by taking a hydrophobic monomer alkyl acrylate, alkyl methacrylate or cyanoacrylate and a hydrophilic polymer chitosan derivative as skeletons and adding a crosslinking agent to crosslink. The preparation method comprises the following steps of: carrying out free radical reaction on the amino group of the hydrophilic polymer in the presence of an initiator and then reacting with the hydrophobic monomer; adding the crosslinking agent again for further reaction; and finally, purifying so as to obtain the particle. The bead-shaped amphipathic nano particle provided by the invention can be applied as an active component carrier, and can be specifically used for production of medicaments, nourishments, protecting agents and cosmetics. Compared with the prior art, the nano particle disclosed by the invention is simple and convenient in preparation process and good in stability, and can increase the intracellular accumulation of the medicament.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and in particular relates to a beaded nanoparticle and a preparation method and application thereof. Background technique [0002] Antitumor drugs have poor water solubility, large side effects and are easily eliminated by tumor cells, resulting in low therapeutic efficiency. Nanoparticles have been widely used in the fields of biology and pharmacy, especially as drug delivery systems. Researchers prepare various inorganic and organic nanoparticles to solubilize insoluble drugs, adjust drug release rate, improve drug bioavailability, enhance targeting, and improve in vivo distribution, thereby improving drug efficacy and reducing side effects. Most of the nanoparticles currently used as drug carriers are dispersed spherical. [0003] However, the preparation and application of non-spherical nanoparticles mainly focus on inorganic nanoparticles, such as gold nanoparticles and carbon nanotu...

Claims

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Application Information

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IPC IPC(8): C08J3/24C08L51/02C08K5/07C08F251/00C08B37/08A61K47/36A61K8/91C12N15/87A01N25/10
Inventor 印春华胡义平
Owner FUDAN UNIV
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