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Pharmaceutical composition containing dimethicone/ simethicone

A technology of simethicone and simethicone is applied in the field of medicine to achieve the effects of uniform and stable drug quality, exact effect and improved clarity

Active Publication Date: 2013-12-11
重庆健能医药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it is often used clinically for dyspnea caused by a large amount of sticky sputum, such as dyspnea after surgery, acute and chronic bronchitis, bronchiectasis, tuberculosis, pneumonia, emphysema, etc. Phlegm blocking the trachea, etc., can still be used for detoxification of acetaminophen poisoning

Method used

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  • Pharmaceutical composition containing dimethicone/ simethicone
  • Pharmaceutical composition containing dimethicone/ simethicone
  • Pharmaceutical composition containing dimethicone/ simethicone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Preparation of ethylamino silicone oil composition granules

[0081] 1. Prescription:

[0082]

[0083] 2. Specific steps:

[0084] (1) Pass acetylcysteine ​​and sucrose powder through a 100-mesh sieve respectively, and set aside;

[0085] (2) Weigh the raw and auxiliary materials according to the prescription quantity;

[0086] (3) After mixing simethicone and silicon dioxide, place it at 150°C for 3 hours, take it out after cooling;

[0087] (4) After mixing acetylcysteine ​​with sucrose powder and starch evenly, add it to the mixture of simethicone and silicon dioxide, mix it several times to make it uniform, and use an appropriate amount of ethanol to make a suitable soft material;

[0088] (5) prepare wet granules with 20 mesh sieves;

[0089] (6) Dry the wet granules at 60-70°C;

[0090] (7) 18 mesh sieves of dry particles are granulated;

[0091] (8) Sieve with 10 mesh sieves and 80 mesh sieves, after removing large particles and fine powder, get semi-fi...

Embodiment 2

[0097] Preparation of ethylamine silicone oil composition powder

[0098] 1. Prescription:

[0099]

[0100] 2. Specific steps:

[0101] (1) Acetylcysteine ​​and glucose are passed through a 100-mesh sieve respectively, and set aside;

[0102] (2) Weigh the raw and auxiliary materials according to the prescription quantity;

[0103] (3) Adsorb simethicone with glucose, mix thoroughly to make it uniform, then mix evenly with acetylcysteine ​​and micropowder silica gel to obtain a semi-finished product;

[0104] (4) The semi-finished product is filled into bags after being inspected for appearance and content of the main drug to obtain the finished product;

[0105] (5) After the finished product passes the inspection, it is put into storage.

[0106] 3. Clinical use

[0107] 20 minutes before digestive endoscopy and treatment or imaging examination, take 1 bag of ethylamine silicone oil composition powder, dissolve and disperse with about 50 ml of water, take it orally,...

Embodiment 3

[0109] Preparation of ethylamino silicone oil composition suspension

[0110] 1. Prescription:

[0111]

[0112]

[0113] 2. Specific steps:

[0114] (1) Acetylcysteine, microcrystalline cellulose, and xanthan gum are passed through a 100-mesh sieve respectively, and set aside; purified water is boiled and deoxidized, set aside; sodium hydroxide is prepared into a sodium hydroxide solution with a concentration of 1M, set aside ;

[0115] (2) Weigh the raw and auxiliary materials according to the prescription quantity;

[0116] (3) After mixing simethicone and silicon dioxide, place it at 150°C for 3 hours, take it out after cooling, and obtain mixture I; dissolve ethyl p-hydroxybenzoate in ethanol to obtain solution I, and set aside; ethylenediaminetetraacetic acid Dissolve disodium and aspartame completely with an appropriate amount of purified water to obtain solution II, which is set aside;

[0117](4) After mixing acetylcysteine ​​with microcrystalline cellulose ...

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Abstract

The present invention provides a pharmaceutical composition containing dimethicone / simethicone, mainly prepared from the following raw materials of portion by weight: acetylcysteine or pharmaceutically acceptable salts thereof 1-1000 portion and dimethicone or simethicone 1-500 portion. The composition can be prepared to form various kinds of pharmaceutically acceptable formulations. The composition can be used as an auxiliary medicine administrated before the gastrointestinal endoscopy and treatment or imaging examination. Compared with using acetylcysteine, dimethicone or simethicone alone at the same dosage, the composition of the present invention has stronger effects of defoaming and eliminating mucus.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition of acetylcysteine ​​or its pharmaceutically acceptable salt and simethicone / simethicone. [0002] Background technique [0003] Digestive endoscopy plays a very important role in the diagnosis of gastrointestinal diseases. It is favored by doctors because of its intuitiveness and simplicity, and it is especially commonly used in clinical diagnosis and treatment. However, due to the large amount of foam and mucus in the digestive tract, the visual field is unclear, the examination time is prolonged, the patient’s pain is increased, and it is easy to cause misdiagnosis and missed diagnosis, which is not conducive to the early diagnosis and discovery of digestive tract diseases. [0004] Simethicone (Ⅰ) is the most commonly used medical antifoaming agent in clinical practice, and is often used for preoperative defoaming in digestive endoscopy and treatm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00A61K31/198A61K47/34A61K9/10A61K9/107A61K9/14A61K9/16
CPCA61K49/00A61K31/198A61K9/16
Inventor 王国华
Owner 重庆健能医药开发有限公司
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