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Porous stent with network passage and preparation method of porous stent

A technology of porous scaffolds and network channels, applied in the field of biomaterials and regenerative medicine, can solve the problem of no difference in effect

Inactive Publication Date: 2012-04-25
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lu J X et al [Bai F, et al. Tissue Engineering Part A. 2010, 16: 3791-3803] have done a lot of research on the connection path of scaffold pores, they will have precise pore diameter and connection The diameter of β-tricalcium phosphate (β-TCP) porous material was implanted into animals to study the formation of blood vessels. It was found that the connection diameter was more important for blood vessel formation than the pore size, but when the pore size was greater than 400 μm, the two effects were not different

Method used

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  • Porous stent with network passage and preparation method of porous stent
  • Porous stent with network passage and preparation method of porous stent
  • Porous stent with network passage and preparation method of porous stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Add 1.8 g β-TCP to 1.1 g 5% polyvinyl alcohol (PVA) aqueous solution, stir, grind, then add 0.45 g 380-550 μm diameter paraffin balls and stir evenly, then pour 0.054 g loofah (diameter 300 μm), the scaffold was taken out, placed at room temperature for 24 h, put into a muffle furnace and heated to 1050 °C for sintering, and a porous scaffold with network channels was obtained. A three-dimensional porous scaffold with channels (300 μm in diameter) with a pore size of about 450 μm and a porosity of about 50% was obtained.

Embodiment 2

[0036] Example 2 Add 1.8 g of hydroxyapatite to 1.1 g of 5% PVA aqueous solution, stir, grind, then add 0.45 g of paraffin balls with a diameter of 380-550 μm and mix well, then pour into a mold with 0.054 g of loofah (300 μm in diameter) After compression molding, the scaffold was taken out, left at room temperature for 48 h, placed in a muffle furnace and heated to 1100 °C for sintering to obtain a three-dimensional porous scaffold with a channel (diameter of 300 μm) with a pore diameter of about 450 μm and a porosity of about 50%.

Embodiment 3

[0037] Example 3 Add 1.8g β-TCP to 0.54 g 10% PVA aqueous solution, stir, grind, then add 0.45 g 270-380 μm diameter paraffin balls and stir evenly, then pour into a mold with 0.054 g loofah (diameter 300 μm) for molding After molding, the scaffold was taken out, left at room temperature for 24 h, put into a muffle furnace and heated to 1050 °C for sintering, and a three-dimensional porous scaffold with a channel (diameter of 300 μm) with a pore diameter of about 300 μm and a porosity of about 50% was obtained.

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Abstract

The invention belongs to the technical field of biological materials and regenerative medicine, in particular to a porous stent with a network passage and a preparation method of the porous stent. A matrix material of the porous stent disclosed by the invention can be an inorganic material, such as ceramics, glass, carbon, and the like, can be a macromolecular material with self bonding property, dissolvability and plasticity and can be a composite material of inorganic and macromolecular materials. The preparation method comprises the following steps of: uniformly mixing the matrix material with a pore-forming agent and a network-shaped substance; when the matrix material is the inorganic material, removing the pore-forming agent and the network-shaped substance for preparing by a high-temperature sintering method; and when the matrix material is the macromolecular material or the complex of the macromolecular material and the inorganic material, preparing the porous stent with the network passage by adopting a normal-temperature mould pressing / particle leaching method. According to the porous stent disclosed by the invention, a network passage structure is constructed on a three-dimensional space structure, thus the communication among holes of the stent is increased, and beneficial space is provided for a vessel growing stent by the introduced passage.

Description

technical field [0001] The invention belongs to the technical field of biomaterials and regenerative medicine, and in particular relates to a porous support with network channels and a preparation method thereof. Background technique [0002] Tissue engineering is the basic principle, basic theory, basic technology and basic method of comprehensive applied engineering and life science. The core of tissue engineering is to establish a three-dimensional complex of cells and scaffold materials, that is, a living tissue with vitality, which is used to reconstruct the shape, structure and function of the diseased tissue and achieve permanent replacement. Tissue induction does not introduce exogenous seed cells, but directly implants porous scaffolds to induce cell entry and even differentiation in the in vivo environment. Porous scaffolds play a key role in regenerative medicine research such as tissue engineering and tissue induction. It not only provides structural support for...

Claims

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Application Information

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IPC IPC(8): A61F2/02A61L27/12A61L27/26A61L27/18
Inventor 丁建东屈泽华
Owner FUDAN UNIV
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