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Pharyngitis chewable tablets and molding process thereof

A molding process and chewable tablet technology, applied in the field of tablets, can solve the problems of low dosage form stability and bioavailability, unfavorable patient absorption, poor stability, etc., and achieve increased stability and bioavailability, good taste and stability, The effect of high absorption rate

Active Publication Date: 2012-04-11
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Pharyngitis extract has existing dosage forms, such as granules, which are difficult to take, poor stability, inconvenient to carry and low bioavailability, which largely affects the use of patients
The existing pharyngitis chewable tablets have low bactericidal efficiency, and it is directly processed from raw traditional Chinese medicine, the dosage form stability and bioavailability are low, and it is not conducive to patient absorption

Method used

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  • Pharyngitis chewable tablets and molding process thereof
  • Pharyngitis chewable tablets and molding process thereof
  • Pharyngitis chewable tablets and molding process thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0022] The chewable tablet molding process that increases the stability and bioavailability of the Pharyngitis extract, the formula of the Pharyngitis chewable tablet is composed of the following raw materials in the following weight percentages: 50% Pharyngitis powder as the main drug, 35% mannitol as the filler Agent, 11% lactose, 1% citric acid, 0.2% orange flavor and 0.8% aspartame as flavoring agent, 1% talcum powder, 1% magnesium stearate as glidant, Composition with 10% PVP95% ethanol liquid as binder; Described PVP95% ethanol liquid is the ethanol solution containing povidone K30;

[0023] The specific process of the pharyngitis chewable tablet is as follows:

[0024] 1) extract pharyngitis powder;

[0025] The pharyngitis powder is prepared from honeysuckle, chrysanthemum, platycodon grandiflorum, rehmannia glutinosa, scrophulariaceae, Radix Ophiopogon japonicus, Shegan and licorice in a weight ratio of 3:3:2:2:2:2:2:1; Recipe amount of honeysuckle and chrysanthemum...

Embodiment 2

[0031] Pharyngitis chewable tablet concrete process of the present invention is as follows: the talcum powder of 12g, the magnesium stearate of 12g are as glidant, with the PVP95% ethanol liquid of 120g as binding agent composition;

[0032] 1) extract pharyngitis powder;

[0033] According to the weight ratio of 3: 3: 2: 2: 2: 2: 2: 1, the eight traditional Chinese medicine raw materials of honeysuckle, chrysanthemum, platycodon, rehmannia glutinosa, scrophulariae, Radix Ophiopogon japonicus, Shegan, and licorice were weighed in sequence (that is, 3 parts of honeysuckle , 3 parts of chrysanthemum, 2 parts of bellflower, 2 parts of raw rehmannia, 2 parts of crocodile, 2 parts of Ophiopogon japonicus, 2 parts of shegan, 1 part of licorice) washed and dried for later use;

[0034] Preparation of pharyngitis volatile oil: The honeysuckle and chrysanthemum raw materials measured according to the above formula were added to the supercritical extraction device for CO 2 Supercriti...

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Abstract

The invention relates to pharyngitis chewable tablets and a molding process thereof. The formula of the pharyngitis chewable tablets is composed of the following raw medicines in percent by weight: 50% of pharyngitis powder, 35% of mannitol, 11% of lactose, 1% of citric acid, 0.2% of orange essence, 0.8% of aspartame, 1% of talcum powder, 1% of magnesium stearate and 10% of PVP(povidone)95% ethanol solution, wherein the PVP95% ethanol solution is a povidone K30-containing ethanol solution. The molding process comprises the following steps of: (1) taking the pharyngitis powder; (2) uniformly mixing the pharyngitis powder with the formulated amounts of mannitol and lactose and a flavoring agent; (3) preparing the PVP95% ethanol solution; and (4) spraying the mixture obtained in the step (2) with 10% of PVP95% ethanol solution in percent by weight to prepare a soft material, then granulating by a 20-mesh sieve, drying at 70 DEG C, then finishing granules by the 20-mesh sieve, adding the formulated amounts of magnesium stearate and talcum powder, spraying the granules with the volatile oil obtained by supercritical extraction in the step (1), and tabletting. The pharyngitis chewable tablets have a good bactericidal effect, good taste, good stability and high absorptivity.

Description

technical field [0001] The invention relates to a tablet, in particular to a pharyngitis chewable tablet and its molding process. Specifically, it provides a chewable tablet molding process with good bactericidal effect, which can increase the stability and bioavailability of pharyngitis extract. Background technique [0002] The pharyngitis extract has dosage forms, such as granules, which are difficult to take, poor stability, inconvenient to carry and low bioavailability, which largely affects the use of patients. The existing pharyngitis chewable tablet has low bactericidal efficiency, and it is directly processed from raw materials of traditional Chinese medicine, the dosage form stability and bioavailability are low, and it is also unfavorable for patients to absorb. Contents of the invention [0003] The purpose of the present invention is to provide a pharyngitis chewable tablet and its molding process, which has good bactericidal effect, good taste and stability, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61K47/26A61K9/20A61P11/04A61P31/04
Inventor 文爱东杨志福苏景宽许鹏陆杨张文正曹军王超关月田云杨静
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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