Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Method for preparing o-anisidine by catalytic hydrogenation

A technology for o-anisole and o-nitroanisole, which is applied in the field of catalytic hydrogenation to prepare o-anisole, can solve the problems of high energy consumption, large amount of waste liquid, low product yield and the like, and achieves low energy consumption. consumption, high product quality and high yield

Inactive Publication Date: 2012-03-28
JIANGSU KANGHENG CHEM
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The iron powder reduction method produces a large amount of iron sludge, seriously pollutes the environment, and consumes a lot of energy; the alkali sulfide reduction method has disadvantages such as complex reduction routes, low product yield, and large amount of waste liquid; the electrochemical reduction method consumes too much energy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing o-anisidine by catalytic hydrogenation
  • Method for preparing o-anisidine by catalytic hydrogenation
  • Method for preparing o-anisidine by catalytic hydrogenation

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] 76.5g (0.5mol) of o-nitroanisole, 76.5g of methanol, 2.3g of catalyst Raney-Ni (3% in W%) were added to a 1L autoclave. Control the reaction pressure at 1-1.2MPa, and the reaction temperature at 50-60°C. After 4 hours of reaction, take a sample to detect 99.5% of GC anthranil.

[0023]

example 2

[0025] Add 153g of o-nitroanisole (1.0mol), 153g of methanol, 4.6g of catalyst Raney-Ni (3% in W%) into a 1L high-pressure reactor, and after nitrogen replacement for 3 times, start to raise the temperature and introduce hydrogen to control the reaction The pressure is 1-1.2MPa, the reaction temperature is between 50-60°C, after 4 hours of reaction, a sample is taken to detect 99.4% of GC anthranil, and after recovery of methanol, 115g of light yellow liquid is obtained by rectification under reduced pressure, with a yield of 93.4% , GC99.5% was detected.

[0026]

example 3

[0028] Add 306g of o-nitroanisole (2.0mol), 306g of methanol, 10.2g of catalyst Raney-Ni (3% in W%) into a 1L high-pressure reactor, and after nitrogen replacement for 3 times, start to raise the temperature and introduce hydrogen to control the reaction The pressure is 1-1.2MPa, the reaction temperature is between 50-60°C, and after 4 hours of reaction, a sample is taken to detect 99.5% of GC anthranil, and after recovery of methanol, 236g of light yellow liquid is obtained by rectification under reduced pressure, with a yield of 99.59% , GC99.6% was detected.

[0029]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for preparing o-anisidine by catalytic hydrogenation. The method comprises the following steps of: mixing o-nitroanisole, methanol and a catalyst Raney-Ni, adding the mixture into a pressure kettle, performing replacement by hydrogen, introducing the hydrogen to maintain the pressure of between 0.5 and 2MPa, heating to the temperature of between 40 and 80 DEG C, introducing the hydrogen continuously for 3 to 10 hours, recovering the methanol, separating liquid and rectifying to obtain the o-anisidine. The method has the advantages of environment friendliness, low energy consumption, high yield and high quality of products.

Description

technical field [0001] The invention relates to a method for preparing o-aminoanisole by catalytic hydrogenation. Background technique [0002] Anthranil is an important dye intermediate and pharmaceutical intermediate, which can be used to prepare azo dyes, ice dyes, naphthol AS-OL and other dyes, as well as guaiacol, anisotropy and other pharmaceuticals It can also be used to produce vanillin, which is widely used in the production of fine chemicals such as pesticides, dyes, and pharmaceuticals. [0003] At present, the production route of anthranil mainly contains the following two kinds: [0004] 1. Using o-nitrophenol as a raw material, first methylated and then reduced: [0005] [0006] 2. Using o-chloronitrobenzene as raw material, first methoxylating and then reducing: [0007] [0008] The above two routes are obtained by reducing the nitro group of o-nitroanisole. Traditional nitro reduction methods mainly include iron powder reduction method, alkali s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C217/84C07C213/02
Inventor 邱志刚雍成松
Owner JIANGSU KANGHENG CHEM
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com