Compound zinc undecylenate triamcinolone acetonide ointment and preparation method thereof

The technology of compound zinc undecylenate and triamcinolone acetonide acetate is applied in the field of medicine, which can solve the problems of difficult penetration of drugs, influence clinical curative effect, limited effect and the like, and achieve simple formula, strong anti-inflammatory effect and easy temperature control. Effect

Inactive Publication Date: 2012-03-07
JILIN AODONG GROUP DALIAN PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with the in-depth understanding of the biochemical process of skin structure, function and metabolism in the medical field, people have gradually discovered and realized that due to the strong barrier function of human skin and mucous membrane tissue, traditional transdermal drug delivery methods The role of the drug is very limited, it is difficult for the drug to penetrate into the relevant parts and reach the effective concentration, thus greatly affecting the clinical efficacy

Method used

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Embodiment 1

[0016] Among the present invention, described a kind of compound zinc undecylenate triamcinolone acetonide ointment and preparation method thereof comprise the following steps,

[0017] ① Weigh the zinc undecylenate, undecylenic acid, triamcinolone acetonide acetate, sodium carboxymethylcellulose, glycerin, and distilled water in the weight percentage, and set aside;

[0018] ② Heat zinc undecylenate, undecylenic acid, triamcinolone acetonide acetate, glycerin, and distilled water on a water bath to 60-80°C, stop heating after all dissolve; sprinkle carboxymethylcellulose sodium powder several times Put it in, heat it to 100-120°C, keep it warm for a certain period of time until it is completely dissolved, stop heating, and keep stirring, add the rest of the same temperature distilled water when it is cooled to 80°C, fully stir it into a paste, grind it evenly into a fine and uniform ointment, Vested.

[0019] cases.

[0020] Liu, male, 37 years old, suffered from tinea pedi...

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PUM

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Abstract

The invention discloses a compound zinc undecylenate triamcinolone acetonide ointment and a preparation method thereof. The invention relates to the field of medicine. The compound zinc undecylenate triamcinolone acetonide ointment provided by the invention is composed of zinc undecylenate, undecylenic acid, triamcinolone acetonide acetate, and an emulsion substrate. Compared to existing technologies, the preparation method is advantaged in controllable temperature and simple formula, and the product is advantaged in good characters. With the added triamcinolone acetonide acetate, comprehensive inflammation resisting and allergy resisting effects of the medicine are stronger and more durable. The product and the method are especially suitable for industrial productions.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound zinc undecylenate triamcinolone acetonide ointment and a preparation method thereof. Background technique [0002] Athlete's foot is a very common fungal infectious skin disease. 70-80% of adults have beriberi, but the severity is different. It is often aggravated in summer and alleviated in winter, and some people do not heal all the year round. The traditional way of administering antifungal drugs for the treatment of skin diseases is to directly apply the drugs to the affected part of the patient, so that the drugs can penetrate into the relevant tissues of the human body through the skin, so as to achieve the purpose of treating diseases. In recent years, with the in-depth understanding of the biochemical process of skin structure, function and metabolism in the medical field, people have gradually discovered and realized that due to the strong barrier function of human s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K31/201A61K9/06A61P31/10
Inventor 刘德胜
Owner JILIN AODONG GROUP DALIAN PHARMACEUTICAL CO LTD
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