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Traditional Chinese medicinal compound extract product for protecting liver and preparation method thereof

An extraction method and extract technology are applied in the application field of preparing liver-protecting pharmaceutical preparations and health food, and can solve the problems of not directly killing hepatitis virus and the like

Inactive Publication Date: 2012-02-29
张宁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, neither traditional Chinese medicine nor modern medicine has a good way to directly kill the hepatitis virus in the patient's body

Method used

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  • Traditional Chinese medicinal compound extract product for protecting liver and preparation method thereof
  • Traditional Chinese medicinal compound extract product for protecting liver and preparation method thereof
  • Traditional Chinese medicinal compound extract product for protecting liver and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 (protective effect of TQW on ConA-induced liver injury model mice)

[0025] The mechanism of liver injury induced by ConA is similar to that caused by hepatitis virus. This example uses this model to verify the protective effect of TQW on liver injury caused by viral hepatitis.

[0026] 1 Materials and methods

[0027] 1.1 Materials

[0028] Sixty clean-grade ICR male mice, weighing 18-20 g and aged 4-5 weeks, were purchased from the GLP Center of Heilongjiang University of Traditional Chinese Medicine.

[0029] TQW suspension: Suspend TQW in distilled water.

[0030] ConA (concanavalin A) type IV (sigma company), under aseptic conditions before use, is prepared with 0.9% sodium chloride injection to prepare a 0.2% solution, and is sterilized by filtration through a 0.22um microporous membrane.

[0031] Bifendate tablets (Shanghai Tianping Pharmaceutical Factory), made into water suspension before use.

[0032] Alanine Aminotransferase (ALT) Kit, Aspartate...

Embodiment 2

[0052] Example 2 (protective effect of TQW on alcohol-induced liver injury model mice)

[0053] In this example, an animal model of alcohol-induced liver injury was used to verify the protective effect of TQW on alcohol-induced liver injury.

[0054] 1 Materials and methods

[0055] 1.1 Materials

[0056] Sixty clean-grade ICR male mice, weighing 18-20 g and aged 4-5 weeks, were purchased from the GLP Center of Heilongjiang University of Traditional Chinese Medicine.

[0057] TQW suspension: Suspend TQW in distilled water.

[0058] 60% medical alcohol: take 95% medical alcohol and dilute it with distilled water.

[0059] Bifendate tablets (Shanghai Tianping Pharmaceutical Factory), made into water suspension before use.

[0060] Alanine aminotransferase (ALT) kit, aspartate aminotransferase (AST) kit, superoxide dismutase (SOD) kit, malondialdehyde (MDA) kit (Nanjing Jiancheng Bioengineering Co., Ltd. graduate School).

[0061] 1.2 Method

[0062] 1.2.1 Modeling and gro...

Embodiment 3

[0082] Embodiment 3 (TQW to CCl 4 Protective effect of induced liver injury model rats)

[0083] CCl 4 The rat model of liver injury is currently recognized as an animal model of chemical liver injury, and this example is used to verify the protective effect of TQW on chemical liver injury.

[0084] 1 Materials and methods

[0085] 1.1 Materials

[0086] Sixty clean-grade Wistar rats, weighing 180-220 g, male and female, 6-8 weeks old, were purchased from the GLP Center of Heilongjiang University of Traditional Chinese Medicine.

[0087] TQW suspension: Suspend TQW in distilled water.

[0088] Bifendate tablets (Shanghai Tianping Pharmaceutical Factory), made into water suspension before use.

[0089] CCl 4 (Shenyang Chemical Reagent Factory); Alanine Aminotransferase (ALT) Kit, Aspartate Aminotransferase (AST) Kit, Superoxide Dismutase (SOD) Kit, Malondialdehyde (MDA) Kit (Nanjing Jiancheng Institute of Bioengineering).

[0090] 1.2 Method

[0091] 1.2.1 Modeling and...

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PUM

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Abstract

The invention discloses a traditional Chinese medicinal compound extract product for protecting liver. Raw materials of the traditional Chinese medicinal compound extract product contain eight traditional Chinese medicines such as Peach Seed, Patrinia villosa Juss, Plantain seed, Xanthoceras sorbifolia Bunge, Chinese angelica, white peony root, radix bupleuri and licorice. The extract product provided by the invention is prepared under a certain technological parameters by the adoption of the supercritical carbon dioxide extraction technology and the macroporous resin enrichment technology. The extract product has an obvious function of preventing liver injury and can be directly and safely applied in the preparation of liver-protecting medicinal preparations and health food.

Description

technical field [0001] The present invention relates to a compound extract of traditional Chinese medicine, in particular to a method of using carbon dioxide supercritical extraction technology and macroporous adsorption resin enrichment technology, which is composed of peach kernels, Patrinia dahliae, Semen Plantaginis, S. sorbifolium seed kernels, angelica, Extracts made from Radix Paeoniae Alba, Radix Bupleurum and Licorice Root have obvious anti-liver damage effect. The invention also relates to the application of the extract in the preparation of hepatoprotective pharmaceutical preparations and health food. Background technique [0002] Liver injury is a common pathological state of many liver diseases, among which, liver injury caused by viral hepatitis, alcoholic liver injury and chemical liver injury caused by drugs and poisons are the most common, and long-term liver injury often leads to Liver fibrosis, even liver cirrhosis, liver cancer is an important motivating...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/77A61P1/16A23L1/29A23L33/00
Inventor 张宁张春蕾周琦朴成玉赵旭祁永华王发善
Owner 张宁
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